Fragile histidine triad protein expression in colorectal adenoma and carcinoma

2017 ◽  
Vol 37 (1) ◽  
pp. 91-103
Author(s):  
Mona A. Abd El-Azeem ◽  
Aliaa A. Shams El-Deen ◽  
Faika A.Y. El-Tatawy ◽  
Nehal A.N. Haebah
Keyword(s):  
Protein Expression ◽  
Colorectal Adenoma ◽  
Fragile Histidine Triad

scholarly journals Fragile histidine triad protein expression in nonsmall cell lung cancer and correlation with Ki-67 and with p53

2003 ◽  
Vol 21 (5) ◽  
pp. 753-758 ◽  
Author(s):  
C. Mascaux ◽  
B. Martin ◽  
J.M. Verdebout ◽  
A.P. Meert ◽  
V. Ninane ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Protein Expression ◽  
Cell Lung Cancer ◽  
Nonsmall Cell Lung Cancer ◽  
Ki 67 ◽  
Fragile Histidine Triad

4. Identification of distinctive protein expression patterns in colorectal adenoma

Pathology ◽  
2011 ◽  
Vol 43 ◽  
pp. S90-S91
Author(s):  
C. Clarke ◽  
F.F. Lam ◽  
L. Jankova ◽  
O.F. Dent ◽  
M.P. Molloy ◽  
...  
Keyword(s):  
Protein Expression ◽  
Colorectal Adenoma ◽  
Expression Patterns

Fragile Histidine Triad (FHIT) Gene and Its Association with p53 Protein Expression in the Progression of Gall Bladder Cancer

2009 ◽  
Vol 27 (7) ◽  
pp. 764-773 ◽  
Author(s):  
T. Padma Priya ◽  
V. K. Kapoor ◽  
Narendra Krishnani ◽  
Vinita Agrawal ◽  
Suraksha Agarwal
Keyword(s):  
Bladder Cancer ◽  
Gall Bladder ◽  
Protein Expression ◽  
P53 Protein ◽  
Gall Bladder Cancer ◽  
Fhit Gene ◽  
Fragile Histidine Triad ◽  
P53 Protein Expression

scholarly journals Lumican and versican protein expression are associated with colorectal adenoma-to-carcinoma progression

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0174768 ◽  
Author(s):  
Meike de Wit ◽  
Beatriz Carvalho ◽  
Pien M. Delis-van Diemen ◽  
Carolien van Alphen ◽  
Jeroen A. M. Beliën ◽  
...  
Keyword(s):  
Protein Expression ◽  
Colorectal Adenoma

scholarly journals Clinicopathological significance of the fragile histidine triad transcription protein expression in laryngeal carcinogenesis

2008 ◽  
Author(s):  
Koichi Kitamura ◽  
Ken Hayashi ◽  
Ryo Kobayashi ◽  
Hideaki Ishii ◽  
Jun Matsubayashi ◽  
...  
Keyword(s):  
Protein Expression ◽  
Fragile Histidine Triad ◽  
Clinicopathological Significance

Decreased Fragile Histidine Triad Gene Protein Expression Is Associated With Worse Prognosis in Oral Squamous Carcinoma

2006 ◽  
Vol 130 (2) ◽  
pp. 158-164
Author(s):  
Leana A. Guerin ◽  
Henry T. Hoffman ◽  
M. Bridget Zimmerman ◽  
Robert A. Robinson
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Protein Expression ◽  
Microsatellite Instability ◽  
Cell Carcinoma ◽  
Loss Of Heterozygosity ◽  
Squamous Cell ◽  
Fhit Gene ◽  
Fragile Histidine Triad ◽  
Fhit Protein

Abstract Context.—Fragile histidine triad (FHIT) gene is thought to be a tumor suppressor; abnormalities in expression have been reported in a variety of neoplasms. Objective.—To determine whether abnormalities of FHIT protein expression or loss of heterozygosity in the FHIT gene were correlated with survival or other clinical parameters in patients with oral cavity squamous cell carcinoma. Design.—Fifty-three patients with initial surgical treatment of oral cavity squamous cell carcinoma were followed a minimum of 5 years or until death. The FHIT protein expression was studied by immunohistochemistry in all patients, and a subset of 20 patients was studied for allelic loss of heterozygosity and microsatellite instability using formalin-fixed, paraffin-embedded tissue. Results.—Sixty-one percent of patients whose tumors had reduced FHIT expression were dead of disease, and 37% of patients whose tumors exhibited preserved FHIT expression were dead of disease at 5-year follow-up. Log-rank analysis showed that patients retaining FHIT expression had a longer overall survival (P = .03) and disease-free survival (P = .01). The FHIT expression was not correlated with node status or clinical stage. Loss of heterozygosity was seen in 10 (50%) of 20 tumors, low levels of microsatellite instability in 4 (20%) of 20 tumors, and high levels of microsatellite instability in 1 (5%) of 20 tumors tested. Conclusions.—The FHIT gene was associated with a worse survival outcome when its expression was reduced in patients with oral cavity squamous cell carcinoma. Loss of heterozygosity in the gene was common, but no correlation with protein expression was found. Neither loss of heterozygosity nor microsatellite instability was found to correlate with survival. Because genomic alterations involving loss of heterozygosity of the FHIT gene were not associated with protein expression in these tumors, the presence or absence of FHIT expression may be controlled by other factors.

S1981 Septin 9 mRNA, Protein Expression and Methylated DNA Level in Colorectal Adenoma-Dysplasia-Carcinoma Sequence

2009 ◽  
Vol 136 (5) ◽  
pp. A-306
Author(s):  
Kinga Tóth ◽  
Sándor Spisák ◽  
Orsolya Galamb ◽  
Ferenc Sipos ◽  
Barnabas Wichmann ◽  
...  
Keyword(s):  
Protein Expression ◽  
Colorectal Adenoma ◽  
Methylated Dna ◽  
Septin 9
Sign in / Sign up

Export Citation Format

Share Document