Prolonging Sympathetic Blockade for Complex Regional Pain Syndrome: Is Botulinum Toxin the Answer?

2021 ◽  
Author(s):  
Vinita Singh ◽  
Steven P. Cohen
Keyword(s):  
Botulinum Toxin ◽  
Complex Regional Pain Syndrome ◽  
Pain Syndrome ◽  
Sympathetic Blockade

scholarly journals Local anaesthetic sympathetic blockade for complex regional pain syndrome

2016 ◽  
Author(s):  
Neil E O'Connell ◽  
Benedict M Wand ◽  
William Gibson ◽  
Daniel B Carr ◽  
Frank Birklein ◽  
...  
Keyword(s):  
Complex Regional Pain Syndrome ◽  
Local Anaesthetic ◽  
Pain Syndrome ◽  
Sympathetic Blockade

scholarly journals Botulinum Toxin Type A for Lumbar Sympathetic Ganglion Block in Complex Regional Pain Syndrome: A Randomized Trial

2021 ◽  
Author(s):  
Yongjae Yoo ◽  
Chang-Soon Lee ◽  
Jungsoo Kim ◽  
Dongwon Jo ◽  
Jee Youn Moon
Keyword(s):  
Botulinum Toxin ◽  
Complex Regional Pain Syndrome ◽  
Sympathetic Ganglion ◽  
Botulinum Toxin Type A ◽  
Pain Syndrome ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Control Group ◽  
Ganglion Block ◽  
Relative Temperature

Background The present study was designed to test the hypothesis that botulinum toxin would prolong the duration of a lumbar sympathetic block measured through a sustained increase in skin temperature. The authors performed a randomized, double-blind, controlled trial to investigate the clinical outcome of botulinum toxin type A for lumbar sympathetic ganglion block in patients with complex regional pain syndrome. Methods Lumbar sympathetic ganglion block was conducted in patients with lower-extremity complex regional pain syndrome using 75 IU of botulinum toxin type A (botulinum toxin group) and local anesthetic (control group). The primary outcome was the change in the relative temperature difference on the blocked sole compared with the contralateral sole at 1 postoperative month. The secondary outcomes were the 3-month changes in relative temperature differences, as well as the pain intensity changes. Results A total of 48 participants (N = 24/group) were randomly assigned. The change in relative temperature increase was higher in the botulinum toxin group than in the control group (1.0°C ± 1.3 vs. 0.1°C ± 0.8, respectively; difference: 0.9°C [95% CI, 0.3 to 1.5]; P = 0.006), which was maintained at 3 months (1.1°C ± 0.8 vs. –0.2°C ± 1.2, respectively; P = 0.009). Moreover, pain intensity was greatly reduced in the botulinum toxin group compared with the control group at 1 month (–2.2 ± 1.0 vs. –1.0 ± 1.6, respectively; P = 0.003) and 3 months (–2.0 ± 1.0 vs. –0.6 ± 1.6, respectively; P = 0.003). There were no severe adverse events pertinent to botulinum toxin injection. Conclusions In patients with complex regional pain syndrome, lumbar sympathetic ganglion block using botulinum toxin type A increased the temperature of the affected foot for 3 months and also reduced the pain. Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New

scholarly journals Botulinum Toxin A for Treatment of Allodynia of Complex Regional Pain Syndrome: A Pilot Study

Pain Medicine ◽  
2010 ◽  
Vol 11 (9) ◽  
pp. 1411-1414 ◽  
Author(s):  
Delaram Safarpour ◽  
Arash Salardini ◽  
Diana Richardson ◽  
Bahman Jabbari
Keyword(s):  
Botulinum Toxin ◽  
Pilot Study ◽  
Complex Regional Pain Syndrome ◽  
Botulinum Toxin A ◽  
Pain Syndrome ◽  
Toxin A

scholarly journals Sympathetic blockade for complex regional pain syndrome

Pain ◽  
2014 ◽  
Vol 155 (11) ◽  
pp. 2218-2219 ◽  
Author(s):  
Peter D. Drummond ◽  
Philip M. Finch
Keyword(s):  
Complex Regional Pain Syndrome ◽  
Pain Syndrome ◽  
Sympathetic Blockade

Usefulness of botulinum toxin A in complex regional pain syndrome

Toxicon ◽  
2013 ◽  
Vol 68 ◽  
pp. 122
Author(s):  
T. Vogt ◽  
F. Birklein ◽  
C. Geber
Keyword(s):  
Botulinum Toxin ◽  
Complex Regional Pain Syndrome ◽  
Botulinum Toxin A ◽  
Pain Syndrome ◽  
Toxin A
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