scholarly journals Prognostic Factors for 30-Day Mortality in Critically Ill Patients With Coronavirus Disease 2019: An Observational Cohort Study

2020 ◽  
Vol 49 (1) ◽  
pp. 102-111 ◽  
Author(s):  
Paloma Ferrando-Vivas ◽  
James Doidge ◽  
Karen Thomas ◽  
Doug W. Gould ◽  
Paul Mouncey ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prognostic Factors ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Observational Cohort Study ◽  
Observational Cohort

scholarly journals Pharmacokinetic/Pharmacodynamic Target Attainment Based on Measured Versus Predicted Unbound Ceftriaxone Concentrations in Critically Ill Patients with Pneumonia: An Observational Cohort Study

Antibiotics ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 557
Author(s):  
Matthias Gijsen ◽  
Erwin Dreesen ◽  
Ruth Van Daele ◽  
Pieter Annaert ◽  
Yves Debaveye ◽  
...  
Keyword(s):  
Renal Function ◽  
Cohort Study ◽  
Protein Binding ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Observational Cohort Study ◽  
Target Attainment ◽  
Binding Model ◽  
Observational Cohort ◽  
The Impact

The impact of ceftriaxone pharmacokinetic alterations on protein binding and PK/PD target attainment still remains unclear. We evaluated pharmacokinetic/pharmacodynamic (PK/PD) target attainment of unbound ceftriaxone in critically ill patients with severe community-acquired pneumonia (CAP). Besides, we evaluated the accuracy of predicted vs. measured unbound ceftriaxone concentrations, and its impact on PK/PD target attainment. A prospective observational cohort study was carried out in adult patients admitted to the intensive care unit with severe CAP. Ceftriaxone 2 g q24h intermittent infusion was administered to all patients. Successful PK/PD target attainment was defined as unbound trough concentrations above 1 or 4 mg/L throughout the whole dosing interval. Acceptable overall PK/PD target attainment was defined as successful target attainment in ≥90% of all dosing intervals. Measured unbound ceftriaxone concentrations (CEFu) were compared to unbound concentrations predicted from various protein binding models. Thirty-one patients were included. The 1 mg/L and 4 mg/L targets were reached in 26/32 (81%) and 15/32 (47%) trough samples, respectively. Increased renal function was associated with the failure to attain both PK/PD targets. Unbound ceftriaxone concentrations predicted by the protein binding model developed in the present study showed acceptable bias and precision and had no major impact on PK/PD target attainment. We showed suboptimal (i.e., <90%) unbound ceftriaxone PK/PD target attainment when using a standard 2 g q24h dosing regimen in critically ill patients with severe CAP. Renal function was the major driver for the failure to attain the predefined targets, in accordance with results found in general and septic ICU patients. Interestingly, CEFu was reliably predicted from CEFt without major impact on clinical decisions regarding PK/PD target attainment. This suggests that, when carefully selecting a protein binding model, CEFu does not need to be measured. As a result, the turn-around time and cost for ceftriaxone quantification can be substantially reduced.

Peripheral muscular ultrasound as outcome assessment tool in critically ill patients on mechanical ventilation: An observational cohort study

2021 ◽  
Author(s):  
Diogo Oliveira Toledo ◽  
Branca Jardini de Freitas ◽  
Rogério Dib ◽  
Flavia Julie do Amaral Pfeilsticker ◽  
Dyaiane Marques dos Santos ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Cohort Study ◽  
Outcome Assessment ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Assessment Tool ◽  
Observational Cohort Study ◽  
Observational Cohort

scholarly journals Incidence and short-term consequences of delirium in critically ill patients: A prospective observational cohort study

2012 ◽  
Vol 49 (7) ◽  
pp. 775-783 ◽  
Author(s):  
Mark van den Boogaard ◽  
Lisette Schoonhoven ◽  
Johannes G. van der Hoeven ◽  
Theo van Achterberg ◽  
Peter Pickkers
Keyword(s):  
Cohort Study ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
Short Term ◽  
Observational Cohort

Incidence and outcomes of delirium in nonintubated critically ill patients: A prospective observational cohort study

2019 ◽  
Vol 16 (4) ◽  
pp. 213
Author(s):  
BharathKumar Tirupakuzhi Vijayaraghavan ◽  
Hari Naveen ◽  
Sooraj Kumar ◽  
Ramesh Venkataraman ◽  
Nagarajan Ramakrishnan
Keyword(s):  
Cohort Study ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
Observational Cohort
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