scholarly journals Analysis of MNS16A VNTR polymorphic sequence variations of the TERT gene and associated risk for development of bladder cancer

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Iqra Anwar ◽  
Arshad A. Pandith ◽  
Mohammad S. Wani ◽  
Hyder Mir ◽  
Meena Godha ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Sequence Variations ◽  
Tert Gene

scholarly journals The MNS16A VNTR polymorphism of the TERT gene in bladder cancer

2020 ◽  
Vol 46 (1) ◽  
pp. 44-49
Author(s):  
Songul Budak Diler ◽  
◽  
Fikriye Polat ◽  
Gunsel Bingol ◽  
◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Vntr Polymorphism ◽  
Tert Gene

scholarly journals The mitochondrial C16069T polymorphism, not mitochondrial D310 (D-loop) mononucleotide sequence variations, is associated with bladder cancer

2013 ◽  
Vol 13 (1) ◽  
pp. 120 ◽  
Author(s):  
Nasser Shakhssalim ◽  
Massoud Houshmand ◽  
Behnam Kamalidehghan ◽  
Abolfazl Faraji ◽  
Reza Sarhangnejad ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Sequence Variations ◽  
D Loop

scholarly journals Activating Telomerase TERT Promoter Mutations and Their Application for the Detection of Bladder Cancer

2020 ◽  
Vol 21 (17) ◽  
pp. 6034 ◽  
Author(s):  
Maria Zvereva ◽  
Eduard Pisarev ◽  
Ismail Hosen ◽  
Olga Kisil ◽  
Simon Matskeplishvili ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Prospective Cohort ◽  
Clinical Performance ◽  
Case Control Studies ◽  
Activating Mutations ◽  
Non Invasive ◽  
Tert Promoter ◽  
Tert Gene ◽  
Tert Promoter Mutations ◽  
Promoter Mutations

This review summarizes state-of-the-art knowledge in early-generation and novel urine biomarkers targeting the telomerase pathway for the detection and follow-up of bladder cancer (BC). The limitations of the assays detecting telomerase reactivation are discussed and the potential of transcription-activating mutations in the promoter of the TERT gene detected in the urine as promising simple non-invasive BC biomarkers is highlighted. Studies have shown good sensitivity and specificity of the urinary TERT promoter mutations in case-control studies and, more recently, in a pilot prospective cohort study, where the marker was detected up to 10 years prior to clinical diagnosis. However, large prospective cohort studies and intervention studies are required to fully validate their robustness and assess their clinical utility. Furthermore, it may be interesting to evaluate whether the clinical performance of urinary TERT promoter mutations could increase when combined with other simple urinary biomarkers. Finally, different approaches for assessment of TERT promoter mutations in urine samples are presented together with technical challenges, thus highlighting the need of careful technological validation and standardization of laboratory methods prior to translation into clinical practice.

Sex and Racial Disparities in the Treatment and Outcomes of Muscle-invasive Bladder Cancer

Urology ◽  
2020 ◽  
Author(s):  
Jessica Marinaro ◽  
Alexander Zeymo ◽  
Jillian Egan ◽  
Filipe Carvalho ◽  
Ross Krasnow ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Racial Disparities ◽  
Invasive Bladder Cancer ◽  
Muscle Invasive Bladder Cancer ◽  
Muscle Invasive

775: Cell Culture Proteome Identifies CXCL 1 as a Secreted Marker and Mediator for the Tumor Invasion of Bladder Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 260-260 ◽  
Author(s):  
Hiroaki Kawanishi ◽  
Yoshiyuki Matsui ◽  
Toshinari Yamasaki ◽  
Takeshi Takahashi ◽  
Hiroyuki Nishiyama ◽  
...  
Keyword(s):  
Cell Culture ◽  
Bladder Cancer ◽  
Tumor Invasion

774: Improvement of Anti-Angiogenic and Anti-Tumorigenic Efficacy of Thrombospondin-1 by PPAR┌ Ligands in Bladder Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 259-259
Author(s):  
Thomas Nelius ◽  
Hanua Huang ◽  
Stephanie Filleur ◽  
Steven C. Campbell ◽  
Werner de Riese ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Thrombospondin 1 ◽  
Ppar Ligands

769: Matrix Metalloproteinase Polymorphisms are associated with Bladder Cancer Invasiveness

2007 ◽  
Vol 177 (4S) ◽  
pp. 258-258
Author(s):  
A. Karim Kader ◽  
Jun Liu ◽  
Una Shao ◽  
Colin P.N. Dinney ◽  
Jie Lin ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Invasiveness

764: Differential Expression of RAL GTPases and their Effectors in Bladder Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 256-256
Author(s):  
Steven Smith ◽  
Gary Oxford ◽  
Dan Theodorescu
Keyword(s):  
Bladder Cancer ◽  
Differential Expression ◽  
Ral Gtpases

761: Enhanced Chemosensitivity to CPT-11 by a Novel NF-KB Inhibitor, DHMEQ in Bladder Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 255-255
Author(s):  
Eiji Kikuchi ◽  
Jun Nakashima ◽  
Keiichi Yamazaki ◽  
Akira Miyajima ◽  
Yutaka Horiguchi ◽  
...  
Keyword(s):  
Bladder Cancer
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