Microsampling Devices for Routine Therapeutic Drug Monitoring – Are We There Yet?

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Phillip Edgar Morgan
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Therapeutic Drug ◽  
Routine Therapeutic Drug Monitoring

Generation of Pharmacokinetic Data During Routine Therapeutic Drug Monitoring

1993 ◽  
Vol 15 (4) ◽  
pp. 281-288 ◽  
Author(s):  
E. El Desoky ◽  
J. Meinshausen ◽  
K. Bühl ◽  
G. Engel ◽  
A. Harings-Kaim ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Therapeutic Drug ◽  
Pharmacokinetic Data ◽  
Routine Therapeutic Drug Monitoring

scholarly journals Quantification of 15 Antibiotics Widely Used in the Critical Care Unit with a LC-MS/MS System: An Easy Method to Perform a Daily Therapeutic Drug Monitoring

2021 ◽  
Vol 14 (12) ◽  
pp. 1214
Author(s):  
Catherine Feliu ◽  
Celine Konecki ◽  
Tristan Candau ◽  
Damien Vautier ◽  
Cyril Haudecoeur ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Plasma Concentrations ◽  
Ultra Performance Liquid Chromatography ◽  
Therapeutic Drug ◽  
Beta Lactams ◽  
Quadrupole Mass ◽  
Triple Quadrupole Mass Spectrometer ◽  
Easy Method ◽  
Routine Therapeutic Drug Monitoring

Potential under- or overdose of antibiotics may occur in intensive care units due to high variability in plasma concentrations. The risk is either treatment failure or toxicity. Thus, therapeutic drug monitoring of antibiotics may guide dosing adjustment, maximising antibacterial efficacy and minimising toxicity. The aim of this study was to develop and validate a method for the analysis of 15 antibiotics including beta-lactams, linezolid, fluoroquinolones, daptomycin, and clindamycin to have a complete panel in the management of infections. We proposed to develop a fast, sensitive, and quantitative method for the analysis of 15 antibiotics using ultra-performance liquid chromatography coupled with triple quadrupole mass spectrometer (UPLC-MS/MS) technology. this method required only 100 µL of plasma and consisted of a rapid liquid–liquid deproteinisation using methanol. Calibration curves ranged from 0.078 to 500 mg/L depending on the molecules, and were defined according to a therapeutic range. Inter- and intra-assay precisions values were less than 15%. This work described the development and the full validation of a precise, sensitive and accurate assay using UPLC-MS/MS technology. After validation, this new assay was successfully applied to routine therapeutic drug monitoring.

Routine Therapeutic Drug Monitoring of Dabigatran

2020 ◽  
Vol 42 (3) ◽  
pp. 468-472
Author(s):  
Paul Ken Leong Chin ◽  
Richard McNeill ◽  
Hyun Kyoung Lee ◽  
Mei Zhang ◽  
Berit Jensen ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Therapeutic Drug ◽  
Routine Therapeutic Drug Monitoring

scholarly journals Survey Study of Routine Therapeutic Drug Monitoring of Antiepileptics in Okayama University Hospital for 14 Years.

1996 ◽  
Vol 22 (6) ◽  
pp. 591-599
Author(s):  
SYOICHI YAMASHITA ◽  
MASAHIRO MORIYAMA ◽  
KATSUSHI FURUNO ◽  
HIROMU KAWASAKI ◽  
YUTAKA GOMITA
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
University Hospital ◽  
Survey Study ◽  
Therapeutic Drug ◽  
Routine Therapeutic Drug Monitoring

scholarly journals A practice of routine therapeutic drug monitoring for antiepileptics.

1988 ◽  
Vol 14 (5) ◽  
pp. 358-369
Author(s):  
MASAHIKO SHINODA ◽  
YOZO OGURA ◽  
MASAYUKI KATOH ◽  
NORIKO TSUNEKAWA ◽  
MASAKO MAEDA ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Therapeutic Drug ◽  
Routine Therapeutic Drug Monitoring
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