SIGNIFICANCE OF ISCHEMIA-MODIFIED ALBUMIN AS A SIMPLE MEASURE OF OXIDATIVE STRESS AND ITS DISCRIMINATORY ABILITY IN DIABETIC RETINOPATHY

Retina ◽  
2016 ◽  
Vol 36 (6) ◽  
pp. 1049-1057 ◽  
Author(s):  
Varikasuvu Seshadri Reddy ◽  
Sumita Sethi ◽  
Navdeep Gupta ◽  
Poonam Agrawal ◽  
Ram Chander Siwach
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Discriminatory Ability ◽  
Ischemia Modified Albumin ◽  
Simple Measure

Usefulness of ischemia-modified albumin in predicting oxidative stress in patients with vitiligo

2017 ◽  
Vol 11 (6) ◽  
pp. 439-449 ◽  
Author(s):  
Hatice Ataş ◽  
Murat Kocabıyık ◽  
Müzeyyen Gönül ◽  
Yasin Öztürk ◽  
Mustafa Kavutçu
Keyword(s):  
Oxidative Stress ◽  
Ischemia Modified Albumin

scholarly journals Melatonin attenuates oxidative stress and inflammation of Müller cells in diabetic retinopathy via activating the Sirt1 pathway

2021 ◽  
Vol 137 ◽  
pp. 111274
Author(s):  
Yuanyuan Tu ◽  
E Song ◽  
Zhenzhen Wang ◽  
Na Ji ◽  
Linling Zhu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Müller Cells ◽  
Muller Cells

Diabetic retinopathy, oxidative stress and sirtuins: an in depth look in enzymatic patterns and new therapeutic horizons.

2021 ◽  
Author(s):  
Marcella Nebbioso ◽  
Alessandro Lambiase ◽  
Marta Armentano ◽  
Giosuè Tucciarone ◽  
Marta Sacchetti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy

scholarly journals Increased ischemia-modified albumin levels in children with steroid-sensitive nephrotic syndrome

2020 ◽  
Vol 36 (7) ◽  
Author(s):  
Gokhan Cakirca ◽  
Ahmet Guzelcicek ◽  
Kenan Yilmaz ◽  
Cemal Nas
Keyword(s):  
Oxidative Stress ◽  
Nephrotic Syndrome ◽  
Pediatric Nephrology ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Cross Sectional ◽  
Ischemia Modified Albumin ◽  
Creative Commons ◽  
Steroid Sensitive Nephrotic Syndrome ◽  
Steroid Sensitive

Objective: Growing evidence shows that oxidative stress plays an important role in the development and progression of nephrotic syndrome (NS). In this study, we aimed to examine serum IMA levels as an indicator of oxidative stress in children with steroid-sensitive NS (SSNS) in remission and relapse. Methods: This cross-sectional study was carried out at the Pediatric Nephrology Unit of Sanliurfa Training and Research Hospital, Sanliurfa, Turkey, from April 2019 to December 2019. In this study Serum IMA and albumin levels were determined in 70 children with SSNS and 45 healthy controls. Among the children with SSNS, 50 were in remission and 20 were in relapse. Then, adjusted IMA levels were calculated from the IMA/albumin ratio. Results: IMA and adjusted IMA levels significantly increased and albumin significantly decreased in children with SSNS in relapse and remission compared with those of the healthy controls. Moreover, these alterations were more prominent in the relapse group than in the remission group. IMA was inversely correlated with albumin in children with SSNS (r= −0.881, p= <0.001). Conclusions: Our findings demonstrated that elevated IMA and adjusted IMA levels observed in patients with SSNS were associated with increased oxidative stress and could indirectly reflect the degree of oxidative damage in glomerular structures. doi: https://doi.org/10.12669/pjms.36.7.2924 How to cite this:Cakirca G, Guzelcicek A, Yilmaz K, Nas C. Increased ischemia-modified albumin levels in children with steroid-sensitive nephrotic syndrome. Pak J Med Sci. 2020;36(7):---------. doi: https://doi.org/10.12669/pjms.36.7.2924 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Polimorfisme V16A Gen MnSOD pada Penderita Diabetes Melitus Tipe 2 dengan Retinopati

2018 ◽  
Vol 3 (2) ◽  
pp. 37
Author(s):  
Tasmini Tasmini ◽  
R. Haryo Yudono ◽  
Maliyah Madyan
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Gene Polymorphism ◽  
Proliferative Diabetic Retinopathy ◽  
Stress Hyperglycemia ◽  
Type 2 Dm ◽  
Pcr Rflp ◽  
Group 2 ◽  
Mnsod Gene

Complications of diabetes mellitus (DM) include diabetic retinopathy (RD) both non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR). The development of RD depends on environmental and genetic factors. MnSOD gene (manganese-superoxid dismutase) is one of the candidate risk factors gene for RD. The presence of V16A MnSOD gene polymorphism results in decrease of mitochondrial MnSOD enzymes expression and triggers the oxidative stress. Hyperglycemia in DM increases oxidative stress in tissues, including the retina resulting in metabolic abnormalities in the retina, which play a role in the development of DM complications, namely diabetic retinopathy. In Indonesia, especially the Javanese tribes in Yogyakarta, there has never been any research on MnSOD gene polymorphism in type 2 diabetes patients with and without retinopathy. Subjects were Poly Endocrine patients and Eye Polyclinic patients of Dr. Sardjito’s General Hospital, 121 subjects consisting of 63 type 2 DM patients without retinopathy were group 1 (KI) and 58 type 2 DM patients with retinopathy were group 2 (KII) (20 NPDR subjects and 38 PDR subjects). V16A polymorphism of MnSOD gene from leukocytes DNA was analyzed by PCR-RFLP method. From 121 DM subjects, 70 subjects with VV genotype were found, 50 subjects with VA genotype and 1 subject with AA genotype. From 63 non-RD DM subjects, 22 subjects with VA genotypes and 41 subjects with VV genotype were found, while in DM with retinopathy (non-PDR, n = 20) found 6 subjects with VA genotype and 14 subjects with VV genotype, and in DM with retinopathy (PDR, n = 38) found 1 subject with AA genotype, 22 subjects with VA genotype and 15 subjects with VV genotype. In DM with retinopathy (NPDR and PDR, n = 58), 1 subject was found with AA genotype, 27 subjects with VA genotype and 29 subjects with VV genotype.

Ischemia-modified albumin in gynecology

2021 ◽  
Vol 15 (6) ◽  
pp. 455-462
Author(s):  
Mehmet F Kıncı ◽  
Burcu Kasap ◽  
Ahmet A Sivaslıoğlu
Keyword(s):  
Oxidative Stress ◽  
Myocardial Ischemia ◽  
Early Diagnosis ◽  
Oxidative Stress Marker ◽  
Ischemia Modified Albumin ◽  
Stress Marker ◽  
Gynecological Disorders ◽  
The Relationship

Background: Ischemia-modified albumin (IMA) is an oxidative stress marker used to assess the presence and severity of oxidative stress. This marker was first used for early diagnosis of myocardial ischemia. Materials & methods: A variety of IMA studies were carried out to show the effect of oxidative stress on gynecological disorders. Conclusion: This analysis summarizes the literature by conducting electronic research on the relationship between IMA and gynecological disorders.

Sign in / Sign up

Export Citation Format

Share Document