Relationship Between High-Fructose Corn Syrup, Uric Acid, and Metabolic Syndrome

2016 ◽  
Vol 5 (4) ◽  
pp. 88
Author(s):  
Monica J. McChesney
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
High Fructose

The Role of High-Fructose Corn Syrup in Metabolic Syndrome and Hypertension

2010 ◽  
Vol 12 (2) ◽  
pp. 105-112 ◽  
Author(s):  
Leon Ferder ◽  
Marcelo Damián Ferder ◽  
Felipe Inserra
Keyword(s):  
Metabolic Syndrome ◽  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
High Fructose

scholarly journals Effect of Caffeic Acid Phenethyl Ester on Vascular Damage Caused by Consumption of High Fructose Corn Syrup in Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-8
Author(s):  
Aburrahman Gun ◽  
Mehmet Kaya Ozer ◽  
Sedat Bilgic ◽  
Nevin Kocaman ◽  
Gonca Ozan
Keyword(s):  
Metabolic Syndrome ◽  
Caffeic Acid ◽  
Vascular Function ◽  
Vascular Dysfunction ◽  
Caffeic Acid Phenethyl Ester ◽  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
Beneficial Effects ◽  
Fructose Intake ◽  
High Fructose

Fructose corn syrup is cheap sweetener and prolongs the shelf life of products, but fructose intake causes hyperinsulinemia, hypertriglyceridemia, and hypertension. All of them are referred to as metabolic syndrome and they are risk factors for cardiovascular diseases. Hence, the harmful effects of increased fructose intake on health and their prevention should take greater consideration. Caffeic Acid Phenethyl Ester (CAPE) has beneficial effects on metabolic syndrome and vascular function which is important in the prevention of cardiovascular disease. However, there are no known studies about the effect of CAPE on fructose-induced vascular dysfunction. In this study, we examined the effect of CAPE on vascular dysfunction due to high fructose corn syrup (HFCS). HFCS (6 weeks, 30% fed with drinking water) caused vascular dysfunction, but treatment with CAPE (50 micromol/kg i.p. for the last two weeks) effectively restored this problem. Additionally, hypertension in HFCS-fed rats was also decreased in CAPE supplemented rats. CAPE supplements lowered HFCS consumption-induced raise in blood glucose, homocysteine, and cholesterol levels. The aorta tissue endothelial nitric oxide synthase (eNOS) production was decreased in rats given HFCS and in contrast CAPE supplementation efficiently increased its production. The presented results showed that HFCS-induced cardiovascular abnormalities could be prevented by CAPE treatment.

scholarly journals High Fructose Corn Syrup-Moderate Fat Diet Potentiates Anxio-Depressive Behavior and Alters Ventral Striatal Neuronal Signaling

2021 ◽  
Vol 15 ◽  
Author(s):  
Ayanabha Chakraborti ◽  
Christopher Graham ◽  
Sophie Chehade ◽  
Bijal Vashi ◽  
Alan Umfress ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Gut Microbiota ◽  
Glycogen Synthase ◽  
Serum Levels ◽  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
Neuronal Signaling ◽  
High Fructose ◽  
Glur1 Subunit ◽  
The Impact

The neurobiological mechanisms that mediate psychiatric comorbidities associated with metabolic disorders such as obesity, metabolic syndrome and diabetes remain obscure. High fructose corn syrup (HFCS) is widely used in beverages and is often included in food products with moderate or high fat content that have been linked to many serious health issues including diabetes and obesity. However, the impact of such foods on the brain has not been fully characterized. Here, we evaluated the effects of long-term consumption of a HFCS-Moderate Fat diet (HFCS-MFD) on behavior, neuronal signal transduction, gut microbiota, and serum metabolomic profile in mice to better understand how its consumption and resulting obesity and metabolic alterations relate to behavioral dysfunction. Mice fed HFCS-MFD for 16 weeks displayed enhanced anxiogenesis, increased behavioral despair, and impaired social interactions. Furthermore, the HFCS-MFD induced gut microbiota dysbiosis and lowered serum levels of serotonin and its tryptophan-based precursors. Importantly, the HFCS-MFD altered neuronal signaling in the ventral striatum including reduced inhibitory phosphorylation of glycogen synthase kinase 3β (GSK3β), increased expression of ΔFosB, increased Cdk5-dependent phosphorylation of DARPP-32, and reduced PKA-dependent phosphorylation of the GluR1 subunit of the AMPA receptor. These findings suggest that HFCS-MFD-induced changes in the gut microbiota and neuroactive metabolites may contribute to maladaptive alterations in ventral striatal function that underlie neurobehavioral impairment. While future studies are essential to further evaluate the interplay between these factors in obesity and metabolic syndrome-associated behavioral comorbidities, these data underscore the important role of peripheral-CNS interactions in diet-induced behavioral and brain function. This study also highlights the clinical need to address neurobehavioral comorbidities associated with obesity and metabolic syndrome.

scholarly journals The Effect of High-Fructose Corn Syrup Consumption on Triglycerides and Uric Acid

2009 ◽  
Vol 139 (6) ◽  
pp. 1242S-1245S ◽  
Author(s):  
Theodore J. Angelopoulos ◽  
Joshua Lowndes ◽  
Linda Zukley ◽  
Kathleen J. Melanson ◽  
Von Nguyen ◽  
...  
Keyword(s):  
Uric Acid ◽  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
High Fructose

scholarly journals Anti-Inflammatory and Anti-Hyperuricemic Effects of Chrysin on a High Fructose Corn Syrup-Induced Hyperuricemia Rat Model via the Amelioration of Urate Transporters and Inhibition of NLRP3 Inflammasome Signaling Pathway

Antioxidants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 564
Author(s):  
Yi-Hsien Chang ◽  
Yi-Fen Chiang ◽  
Hsin-Yuan Chen ◽  
Yun-Ju Huang ◽  
Kai-Lee Wang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Protein Expression ◽  
Signaling Pathway ◽  
Nlrp3 Inflammasome ◽  
Organic Anion ◽  
Flavonoid Compound ◽  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
High Fructose ◽  
Anti Inflammatory

Hyperuricemia is the main cause of gout and involved in the occurrence of many other diseases such as hyperlipidemia and hypertension correlated with metabolic disorders. Chrysin is a flavonoid compound found naturally in honey, propolis, and mushrooms and has anti-inflammatory and antioxidant effects. However, its mechanism of action is not clear yet. This study investigated the mechanism of chrysin’s anti-hyperuricemic effect in hyperuricemia-induced rats fed with high-fructose corn syrup. Orally administrated chrysin for 28 consecutive days effectively decreased uric acid by inhibiting the activity of xanthine oxidase (XO) in the liver. Moreover, chrysin markedly downregulated the protein expression of uric acid transporter 1 (URAT1) and glucose transporter type 9 (GLUT9) and upregulated the protein expression of organic anion transporter 1 (OAT1) and human ATP-binding cassette subfamily G-2 (ABCG2). In addition, chrysin showed prominent anti-oxidative and inflammatory effects as the malondialdehyde (MDA) and interleukin 1 beta (IL-1β) concentration was reduced in both rat kidney and serum, which aligned with the inhibition of NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome signaling pathway activation. Collectively, our results strongly suggest that chrysin exhibits potent anti-hyperuricemic and anti-inflammatory effects that may yield new adjuvant treatments for gout.

Fructose and high fructose corn syrup: are they a two-edged sword?

2021 ◽  
pp. 1-23
Author(s):  
Nasim Khorshidian ◽  
Mahdi Shadnoush ◽  
Maryam Zabihzadeh Khajavi ◽  
Sara Sohrabvandi ◽  
Mojtaba Yousefi ◽  
...  
Keyword(s):  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
High Fructose
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