Network meta-analysis of Chinese herbal injections combined with the chemotherapy for the treatment of pancreatic cancer

Pancreatic cancer is a common malignancy with a high mortality. Most patients present clinically with advanced pancreatic cancer. Moreover, the effect of radiotherapy or chemotherapy is limited. Complementary and alternative medicines represent exciting adjunctive therapies. In this study, we ascertained the beneficial and adverse effects of Chinese herbal medicine (CHM) in combination with conventional therapy for inoperable pancreatic cancer by using meta-analysis methods for controlled clinical trials. We extracted data for studies searched from six electronic databases that were searched and also assessed the methodological quality of the included studies. We evaluated the following outcome measures: 6-month and 1-year survival rate, objective response rate, disease control rate, quality of life, and adverse effects. The final analysis showed CHM is a promising strategy as an adjunctive therapy to treat advanced or inoperable pancreatic cancer and that CHM in combination with conventional therapy is a promising strategy for resistant disease. However, convincing evidence must be obtained and confirmed by high-quality trials in future studies.

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Statin use decreases the risk of pancreatic cancer occurrence: a meta-analysis

10.26226/morressier.59a6b346d462b80290b54a82 ◽

2017 ◽

Author(s):

Livia Archibugi

Keyword(s):

Pancreatic Cancer ◽

Meta Analysis ◽

Cancer Occurrence ◽

Statin Use

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Faculty of 1000 evaluation for Chinese herbal medicine for diabetic peripheral neuropathy: an updated meta-analysis of 10 high-quality randomized controlled studies.

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.718151305.793487844 ◽

2013 ◽

Author(s):

Sari Kiuru-Enari ◽

Mari Auranen

Keyword(s):

Peripheral Neuropathy ◽

Herbal Medicine ◽

Chinese Herbal Medicine ◽

Diabetic Peripheral Neuropathy ◽

Meta Analysis ◽

High Quality ◽

Randomized Controlled ◽

Chinese Herbal ◽

Randomized Controlled Studies

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Systematic review and meta-analysis of randomized controlled trials of Chinese herbal medicine in the treatment of Sjogren's syndrome

Journal of Chinese Integrative Medicine ◽

10.3736/jcim20110306 ◽

2011 ◽

Vol 9 (3) ◽

pp. 257-274 ◽

Cited By ~ 7

Author(s):

Hui Luo

Keyword(s):

Systematic Review ◽

Herbal Medicine ◽

Randomized Controlled Trials ◽

Chinese Herbal Medicine ◽

Meta Analysis ◽

Sjogren’S Syndrome ◽

Sjogren's Syndrome ◽

Controlled Trials ◽

Randomized Controlled ◽

Chinese Herbal

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Chinese Herbal Medicines for Promoting Blood Circulation and Removing Blood Stasis in Preventing Deep Venous Thrombosis after Total Hip Arthroplasty: A Systematic Review and Meta-Analysis

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207323666200901103732 ◽

2020 ◽

Vol 23 ◽

Author(s):

Hetao Huang ◽

Jianke Pan ◽

Yanhong Han ◽

Lingfeng Zeng ◽

Guihong Liang ◽

...

Keyword(s):

Total Hip Arthroplasty ◽

Hip Arthroplasty ◽

Western Medicine ◽

Blood Circulation ◽

Meta Analysis ◽

Blood Stasis ◽

Herbal Medicines ◽

Controlled Trials ◽

Randomized Controlled ◽

Chinese Herbal

Aim and Objective: To evaluate the efficacy and safety of Chinese herbal medicines for promoting blood circulation and removing blood stasis (PBCRBSM) in preventing deep venous thrombosis (DVT) after total hip arthroplasty (THA). Materials and Methods: The Databases were searched for studies comparing the preventive abilities of PBCRBSM and Western medicine, such as low molecular weight heparin (LMWH), rivaroxaban, and aspirin, as well as for randomized controlled trials on DVT after THA. Data were analyzed using RevMan 5.3 software. Results: A total of 3254 randomized controlled trials were included, including 1630 cases in the experimental group and 1624 cases in the control group. Meta-analysis showed that compared with Western medicine, PBCRBSM reduced the incidence of DVT (OR=0.38, 95% CI [0.30, 0.48], P < 0.001); prolonged activated partial thromboplastin time (APTT) (SMD=0.44, 95% CI [0.35, 0.53], P < 0.001); reduced D-dimer (SMD=-0.75, 95% CI [-0.84，-0.65], P < 0.001), FIB (SMD=-0.61, 95% CI [-0.72, -0.50], P < 0.001), blood viscosity (P<0.01), circumference difference in lower extremities (P<0.01), venous blood flow velocity (SMD=0.97, 95% CI [0.77, 1.16], P < 0.001), and drainage volume (SMD=-1.53, 95% CI [-1.71, -1.35], P < 0.001); and reduced adverse reactions (OR = 0.32, 95% CI [0.19, 0.56], P < 0.001). There was no significant difference in prolonging prothrombin time (PT) between traditional Chinese medicine and Western medicine (SMD = 0.07, 95% CI [-0.0.01). 3, 0.16], P > 0.05. Conclusion: PBCRBSM is an effective method for preventing DVT after THA and has fewer adverse effects.

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Exercise efficacy and prescription during treatment for pancreatic ductal adenocarcinoma: a systematic review

BMC Cancer ◽

10.1186/s12885-020-07733-0 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Dominic O’Connor ◽

Malcolm Brown ◽

Martin Eatock ◽

Richard C. Turkington ◽

Gillian Prue

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Pancreatic Cancer ◽

Adjuvant Therapy ◽

Physical Function ◽

Meta Analysis ◽

Ductal Adenocarcinoma ◽

Key Stakeholders ◽

The Impact

Abstract Background Surgical resection remains the only curative treatment for pancreatic cancer and is associated with significant post-operative morbidity and mortality. Patients eligible for surgery, increasingly receive neo-adjuvant therapy before surgery or adjuvant therapy afterward, inherently exposing them to toxicity. As such, optimizing physical function through exercise during treatment remains imperative to optimize quality of life either before surgery or during rehabilitation. However, current exercise efficacy and prescription in pancreatic cancer is unknown. Therefore, this study aims to summarise the published literature on exercise studies conducted in patients with pancreatic cancer undergoing treatment with a focus on determining the current prescription and progression patterns being used in this population. Methods A systematic review of four databases identified studies evaluating the effects of exercise on aerobic fitness, muscle strength, physical function, body composition, fatigue and quality of life in participants with pancreatic cancer undergoing treatment, published up to 24 July 2020. Two reviewers independently reviewed and appraised the methodological quality of each study. Results Twelve studies with a total of 300 participants were included. Heterogeneity of the literature prevented meta-analysis. Exercise was associated with improvements in outcomes; however, study quality was variable with the majority of studies receiving a weak rating. Conclusions High quality evidence regarding the efficacy and prescription of exercise in pancreatic cancer is lacking. Well-designed trials, which have received feedback and input from key stakeholders prior to implementation, are required to examine the impact of exercise in pancreatic cancer on key cancer related health outcomes.

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A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer

Genome Medicine ◽

10.1186/s13073-020-00816-4 ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Evangelina López de Maturana ◽

◽

Juan Antonio Rodríguez ◽

Lola Alonso ◽

Oscar Lao ◽

...

Keyword(s):

Pancreatic Cancer ◽

Functional Analysis ◽

Genetic Susceptibility ◽

In Silico ◽

Complex Disease ◽

Meta Analysis ◽

Low Frequency ◽

Acinar Cells ◽

Pancreatic Acinar Cells ◽

Phenotypic Variance

Abstract Background Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% of the phenotypic variance. Methods We complemented a new conventional PC GWAS (1D) with genome spatial autocorrelation analysis (2D) permitting to prioritize low frequency variants not detected by GWAS. These were further expanded via Hi-C map (3D) interactions to gain additional insight into the inherited basis of PC. In silico functional analysis of public genomic information allowed prioritization of potentially relevant candidate variants. Results We identified several new variants located in genes for which there is experimental evidence of their implication in the biology and function of pancreatic acinar cells. Among them is a novel independent variant in NR5A2 (rs3790840) with a meta-analysis p value = 5.91E−06 in 1D approach and a Local Moran’s Index (LMI) = 7.76 in 2D approach. We also identified a multi-hit region in CASC8—a lncRNA associated with pancreatic carcinogenesis—with a lowest p value = 6.91E−05. Importantly, two new PC loci were identified both by 2D and 3D approaches: SIAH3 (LMI = 18.24), CTRB2/BCAR1 (LMI = 6.03), in addition to a chromatin interacting region in XBP1—a major regulator of the ER stress and unfolded protein responses in acinar cells—identified by 3D; all of them with a strong in silico functional support. Conclusions This multi-step strategy, combined with an in-depth in silico functional analysis, offers a comprehensive approach to advance the study of PC genetic susceptibility and could be applied to other diseases.

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