scholarly journals The methylenetetrahydrofolate reductase 677T-1298C haplotype is a risk factor for acute lymphoblastic leukemia in children

Medicine ◽  
2017 ◽  
Vol 96 (51) ◽  
pp. e9290 ◽  
Author(s):  
Ewelina Maria Kałużna ◽  
Ewa Strauss ◽  
Bogna Świątek-Kościelna ◽  
Olga Zając-Spychała ◽  
Ewelina Gowin ◽  
...  
Keyword(s):  
Risk Factor ◽  
Acute Lymphoblastic Leukemia ◽  
Methylenetetrahydrofolate Reductase ◽  
Lymphoblastic Leukemia ◽  
Leukemia In Children

Physician compliance and relapse rates of acute lymphoblastic leukemia in children

1988 ◽  
Vol 43 (3) ◽  
pp. 228-232 ◽  
Author(s):  
Marie Peeters ◽  
Gideon Koren ◽  
Difat Jakubovicz ◽  
Alvin Zipursky
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Physician Compliance ◽  
Relapse Rates ◽  
Leukemia In Children

MTHFR 677T-1298C haplotype in acute lymphoblastic leukemia: Impact on methotrexate therapy

2021 ◽  
pp. 107815522110171
Author(s):  
Rim Frikha ◽  
Moez Elloumi ◽  
Tarek Rebai ◽  
Hassen Kamoun
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Methylenetetrahydrofolate Reductase ◽  
Fragment Length Polymorphism ◽  
Lymphoblastic Leukemia ◽  
Allelic Frequency ◽  
Mthfr Gene ◽  
Methotrexate Therapy ◽  
Wild Type ◽  
Functional Variants ◽  
Toxicity Score

Introduction Functional variants of the Methylenetetrahydrofolate reductase ( MTHFR) gene, the C677T and A1298C, have largely investigated in pharmacogenomics of Methotrexate (MTX) in acute lymphoblastic leukemia (ALL), yet the conclusions are inconsistent. In addition; most of these studies do not analyze haplotypes. Here, we investigate the MTHFR 677/1298 genotypes and the 677-1298 haplotype and characterize the MTX response in Northern African ALL patients. Methods Genomic DNA was extracted from whole venous from a total of 28 patients with ALL. Genotyping were carried out with restriction fragment length polymorphism (RFLP). A toxicity score (TS) is calculated for each patient and correlate to the haplotype. Results The allelic frequency of MTHFR 677T-1298C haplotype was 10.7% in ALL patients. According to the toxicity’s score (TS) there was no significant differences between haplotype groups (p = 0.79): TS was higher with wild type of MTHFR (TS = 3.43; SEM ± 0.85) followed by combined genotype (677T-1298C) (TS = 2.67; SEM ± 0.88) and isolated variant (C677T or A1298C) (TS = 2.64; SEM ± 0.92). Conclusion Despite the limitation of this study; our results suggest that the MTHFR 677T-1298C haplotype is common in ALL and may be a promising HD-MTX chemotherapy-related adverse effects biomarker.

High-Dose Cyclophosphamide for the Treatment of Refractory T-Cell Acute Lymphoblastic Leukemia in Children

2014 ◽  
Vol 36 (5) ◽  
pp. e265-e270 ◽  
Author(s):  
Rachel Kobos ◽  
Neerav Shukla ◽  
Thomas Renaud ◽  
Susan E. Prockop ◽  
Farid Boulad ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Lymphoblastic Leukemia ◽  
High Dose ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Leukemia In Children

Nijmegen breakage syndrome (NBS) as a risk factor for CNS involvement in childhood acute lymphoblastic leukemia

2011 ◽  
Vol 57 (1) ◽  
pp. 160-162 ◽  
Author(s):  
Agata Pastorczak ◽  
Malgorzata Stolarska ◽  
Joanna Trelińska ◽  
Joanna Zawitkowska ◽  
Jerzy Kowalczyk ◽  
...  
Keyword(s):  
Risk Factor ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Nijmegen Breakage Syndrome ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Cns Involvement
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