Serum IL-17A in Newly Diagnosed Treatment-Naive Patients with Ulcerative Colitis Reflects Clinical Disease Severity and Predicts the Course of Disease

2013 ◽  
Vol 19 (11) ◽  
pp. 2433-2439 ◽  
Author(s):  
Lena Öhman ◽  
Rahil Dahlén ◽  
Stefan Isaksson ◽  
Åsa Sjöling ◽  
Mary-Jo Wick ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Disease Severity ◽  
Clinical Disease ◽  
Newly Diagnosed ◽  
Course Of Disease ◽  
Treatment Naïve

155 Serum IL-17A in Newly Diagnosed Treatment-Naïve Ulcerative Colitis Patients Reflects Disease Severity and Predicts the Course of Disease

2013 ◽  
Vol 144 (5) ◽  
pp. S-35
Author(s):  
Lena Ohman ◽  
Rahil Dahlen ◽  
Stefan Isaksson ◽  
Asa Sjöling ◽  
Mary Jo Wick ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Disease Severity ◽  
Newly Diagnosed ◽  
Course Of Disease ◽  
Treatment Naïve

Microbial Dysbiosis Associated with Disease Severity in Treatment Naive Pediatric Patients with New-Onset Ulcerative Colitis

2017 ◽  
Vol 152 (5) ◽  
pp. S172-S173
Author(s):  
Melanie Schirmer ◽  
Hera Vlamakis ◽  
Lee A. Denson ◽  
Sonia Davis ◽  
Paul A. Rufo ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Disease Severity ◽  
Pediatric Patients ◽  
Microbial Dysbiosis ◽  
Treatment Naïve ◽  
New Onset

Histological Inflammation in the Endoscopically Uninflamed Mucosa is Associated With Worse Outcomes in Limited Ulcerative Colitis

2021 ◽  
Author(s):  
Catarina Geraldes de Frias Gomes ◽  
Alexandra Sofia Ribeiro de Almeida ◽  
Catarina Callé Lucas Mendes ◽  
Pierre Ellul ◽  
Johan Burisch ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Confidence Interval ◽  
Retrospective Cohort ◽  
Hazard Ratio ◽  
Adjusted Hazard Ratio ◽  
Newly Diagnosed ◽  
Disease Extent ◽  
Treatment Naïve ◽  
Disease Extension

Abstract Background The Montreal classification categorizes patients with ulcerative colitis (UC) based on their macroscopic disease extent. Independent of endoscopic extent, biopsies through all colonic segments should be retrieved during index colonoscopy. However, the prognostic value of histological inflammation at diagnosis in the inflamed and uninflamed regions of the colon has never been assessed. Methods This was a multicenter retrospective cohort study of newly diagnosed patients with treatment-naïve proctitis and left-sided UC. Biopsies from at least 2 colonic segments (endoscopically inflamed and uninflamed mucosa) were retrieved and reviewed by 2 pathologists. Histological features in the endoscopically inflamed and uninflamed mucosa were scored using the Nancy score. The primary outcomes were disease complications (proximal disease extension, need for hospitalization or colectomy) and higher therapeutic requirements (need for steroids or for therapy escalation). Results Overall, 93 treatment-naïve patients were included, with a median follow-up of 44 months (range, 2-329). The prevalence of any histological inflammation above the endoscopic margin was 71%. Proximal disease extension was more frequent in patients with histological inflammation in the endoscopically uninflamed mucosa at diagnosis (21.5% vs 3.4%, P = 0.04). Histological involvement above the endoscopic margin was the only predictor associated with an earlier need for therapy escalation (adjusted hazard ratio, 3.69; 95% confidence interval, 1.05-13.0); P = 0.04) and disease complications (adjusted hazard ratio, 4.79; 95% confidence interval, 1.10-20.9; P = 0.04). Conclusions The presence of histological inflammation in the endoscopically uninflamed mucosa at the time of diagnosis was associated with worse outcomes in limited UC.

scholarly journals DNA hypo-methylation facilitates anti-inflammatory responses in severe ulcerative colitis

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0248905
Author(s):  
Hagar Taman ◽  
Christopher G. Fenton ◽  
Endre Anderssen ◽  
Jon Florholmen ◽  
Ruth H. Paulssen
Keyword(s):  
Ulcerative Colitis ◽  
Dna Methylation ◽  
Disease Severity ◽  
Inflammatory Responses ◽  
Principal Component ◽  
Severe Ulcerative Colitis ◽  
Inflammatory Genes ◽  
Genome Wide ◽  
Treatment Naïve ◽  
Anti Inflammatory

Severe ulcerative colitis (UC) is a potentially life-threatening disease with a potential colorectal cancer (CRC) risk. The aim of this study was to explore the relationship between transcriptomic and genome-wide DNA methylation profiles in a well-stratified, treatment-naïve severe UC patient population in order to define specific epigenetic changes that could be responsible for the grade of disease severity. Mucosal biopsies from treatment-naïve severe UC patients (n = 8), treatment-naïve mild UC (n = 8), and healthy controls (n = 8) underwent both whole transcriptome RNA-Seq and genome-wide DNA bisulfite- sequencing, and principal component analysis (PCA), cell deconvolutions and diverse statistical methods were applied to obtain a dataset of significantly differentially expressed genes (DEGs) with correlation to DNA methylation for severe UC. DNA hypo-methylation correlated with approximately 80% of all DEGs in severe UC when compared to mild UC. Enriched pathways of annotated hypo-methylated genes revealed neutrophil degranulation, and immuno-regulatory interactions of the lymphoid system. Specifically, hypo-methylated anti-inflammatory genes found for severe UC were IL10, SIGLEC5, CD86, CLMP and members of inflammasomes NLRP3 and NLRC4. Hypo-methylation of anti-inflammatory genes during severe UC implies an interplay between the epithelium and lamina propria in order to mitigate inflammation in the gut. The specifically DNA hypo-methylated genes found for severe UC can potentially be useful biomarkers for determining disease severity and in the development of new targeted treatment strategies for severe UC patients.

Viral Load Dynamics and Clinical Disease Severity in Patients with SARS-CoV-2 Infection

2020 ◽  
Author(s):  
Shufa Zheng ◽  
Jian Fan ◽  
Fei Yu ◽  
Baihuan Feng ◽  
Bin Lou ◽  
...  
Keyword(s):  
Viral Load ◽  
Disease Severity ◽  
Clinical Disease

scholarly journals Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Yael Haberman ◽  
Rebekah Karns ◽  
Phillip J. Dexheimer ◽  
Melanie Schirmer ◽  
Judith Somekh ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Treatment Response ◽  
Disease Severity ◽  
Underlying Disease
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