Mesenchymal stromal cells to control donor-specific memory T cells in solid organ transplantation

Exposure of the adaptive immune system to a pathogen can result in the activation and expansion of T cells capable of recognizing not only the specific antigen but also different unrelated antigens, a process which is commonly referred to as heterologous immunity. While such cross-reactivity is favourable in amplifying protective immune responses to pathogens, induction of T cell-mediated heterologous immune responses to allo-antigens in the setting of solid organ transplantation can potentially lead to allograft rejection. In this review, we provide an overview of murine and human studies investigating the incidence and functional properties of virus-specific memory T cells cross-reacting with allo-antigens and discuss their potential relevance in the context of solid organ transplantation.

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ISOLATION AND EX VIVO EXPANSION OF BONE MARROW-DERIVED PORCINE MESENCHYMAL STROMAL CELLS: POTENTIAL FOR APPLICATION IN AN EXPERIMENTAL MODEL OF SOLID ORGAN TRANSPLANTATION IN LARGE ANIMALS

Transplantation Journal ◽

10.1097/00007890-201007272-02051 ◽

2010 ◽

Vol 90 ◽

pp. 1042

Author(s):

L. cobianchi ◽

S. Zonta ◽

M. E. Bernardo ◽

M. A. Avanzini ◽

M. De Martino ◽

...

Keyword(s):

Bone Marrow ◽

Organ Transplantation ◽

Experimental Model ◽

Mesenchymal Stromal Cells ◽

Stromal Cells ◽

Ex Vivo ◽

Solid Organ Transplantation ◽

Ex Vivo Expansion ◽

Solid Organ ◽

Large Animals

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The use of mesenchymal stromal cells in solid organ transplantation

The Biology and Therapeutic Application of Mesenchymal Cells ◽

10.1002/9781118907474.ch56 ◽

2016 ◽

pp. 825-835

Author(s):

Céline Gregoire ◽

Alexandra Briquet ◽

François Jouret ◽

Chantal Lechanteur ◽

Etienne Baudoux ◽

...

Keyword(s):

Organ Transplantation ◽

Mesenchymal Stromal Cells ◽

Stromal Cells ◽

Solid Organ Transplantation ◽

Solid Organ

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Mesenchymal stromal cells to induce tolerance to solid organ transplantation

10.26481/dis.20150422fc ◽

2015 ◽

Author(s):

F. Casiraghi

Keyword(s):

Organ Transplantation ◽

Mesenchymal Stromal Cells ◽

Stromal Cells ◽

Solid Organ Transplantation ◽

Solid Organ

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Combination of mesenchymal stromal cells and machine perfusion is a novel strategy for organ preservation in solid organ transplantation

Cell and Tissue Research ◽

10.1007/s00441-020-03406-3 ◽

2021 ◽

Author(s):

Lingfei Zhao ◽

Chenxia Hu ◽

Fei Han ◽

Dajin Chen ◽

Yanhong Ma ◽

...

Keyword(s):

Organ Transplantation ◽

Mesenchymal Stromal Cells ◽

Stromal Cells ◽

Organ Preservation ◽

Ex Vivo ◽

Solid Organ Transplantation ◽

Organ Shortage ◽

Solid Organ ◽

Machine Perfusion ◽

Organ Function

AbstractOrgan preservation is a prerequisite for an urgent increase in the availability of organs for solid organ transplantation (SOT). An increasing amount of expanded criteria donor (ECD) organs are used clinically. Currently, the paradigm of organ preservation is shifting from simple reduction of cellular metabolic activity to maximal simulation of an ex vivo physiological microenvironment. An ideal organ preservation technique should not only preserve isolated organs but also offer the possibility of rehabilitation and evaluation of organ function prior to transplantation. Based on the fact that mesenchymal stromal cells (MSCs) possess strong regeneration properties, the combination of MSCs with machine perfusion (MP) is expected to be superior to conventional preservation methods. In recent years, several studies have attempted to use this strategy for SOT showing promising outcomes. With better organ function during ex vivo preservation and the potential of utilization of organs previously deemed untransplantable, this strategy is meaningful for patients with organ failure to help overcome organ shortage in the field of SOT.

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