Coxsackievirus B3 Infection Affects Metal-Binding/Transporting Proteins and Trace Elements in the Pancreas in Mice

Pancreas ◽  
2007 ◽  
Vol 35 (3) ◽  
pp. e37-e44 ◽  
Author(s):  
Peter Frisk ◽  
Jonas Tallkvist ◽  
Inga-Lill Gadhasson ◽  
Jonas Blomberg ◽  
Göran Friman ◽  
...  
Keyword(s):  
Trace Elements ◽  
Metal Binding ◽  
Coxsackievirus B3

scholarly journals Spatial Distribution of Trace Elements in Rice Field at Prafi District Manokwari

2016 ◽  
Vol 48 (1) ◽  
pp. 1
Author(s):  
Aplena Elen S. Bless ◽  
Samen Baan ◽  
Yahya Darmawan
Keyword(s):  
Trace Elements ◽  
Soil Ph ◽  
Metal Binding ◽  
Rice Field ◽  
Soil Samples ◽  
Quality Information ◽  
Trace Metal Concentration ◽  
Measure Concentration ◽  
West Papua ◽  
Fe Toxicity

Mapping spatial variability of trace elements in rice Ḁeld is necessary to obtain soil quality information to en-hance rice production. ἀis study was aimed to measure concentration and distribution of Zn, Cu, Fe, Pb, and Cd in two diᴀerent sites (SP1, SP2) of PraḀ rice Ḁeld in Manokwari West Papua. ἀe representative 26 soil samples were analysed for their available trace metal concentration (DTPA), soil pH, and C-organic and soil texture. ἀe result indicated that Fe toxicity and Zn deḀcient problems were encountered in both sites.  Rice Ḁeld in SP2 was more deḀcient in Zn than SP1. Site with the highest trace elements (Zn, Fe, Cu, and Cd) concentration had low soil pH and high C-organic. Acidic soil has higher solubility of metals; while high C-organic could improve the formation of dissolve organic carbon-metal binding, hence it improving the trace metals concentration in soil solution.

Gastrointestinal uptake of trace elements are changed during the course of a common human viral (Coxsackievirus B3) infection in mice

2008 ◽  
Vol 22 (2) ◽  
pp. 120-130 ◽  
Author(s):  
Nils-Gunnar Ilbäck ◽  
Peter Frisk ◽  
Jonas Tallkvist ◽  
Inga-Lill Gadhasson ◽  
Jonas Blomberg ◽  
...  
Keyword(s):  
Trace Elements ◽  
Coxsackievirus B3 ◽  
Gastrointestinal Uptake

scholarly journals Crosstalk of Nrf2 with the Trace Elements Selenium, Iron, Zinc, and Copper

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2112 ◽  
Author(s):  
Maria Schwarz ◽  
Kristina Lossow ◽  
Johannes F. Kopp ◽  
Tanja Schwerdtle ◽  
Anna P. Kipp
Keyword(s):  
Trace Elements ◽  
Trace Element ◽  
Metal Binding ◽  
Target Genes ◽  
Selenium Deficiency ◽  
Whole Body ◽  
Dependent Manner ◽  
Trace Element Status ◽  
Nrf2 Knockout ◽  
Feeding Diets

Trace elements, like Cu, Zn, Fe, or Se, are important for the proper functioning of antioxidant enzymes. However, in excessive amounts, they can also act as pro-oxidants. Accordingly, trace elements influence redox-modulated signaling pathways, such as the Nrf2 pathway. Vice versa, Nrf2 target genes belong to the group of transport and metal binding proteins. In order to investigate whether Nrf2 directly regulates the systemic trace element status, we used mice to study the effect of a constitutive, whole-body Nrf2 knockout on the systemic status of Cu, Zn, Fe, and Se. As the loss of selenoproteins under Se-deprived conditions has been described to further enhance Nrf2 activity, we additionally analyzed the combination of Nrf2 knockout with feeding diets that provide either suboptimal, adequate, or supplemented amounts of Se. Experiments revealed that the Nrf2 knockout partially affected the trace element concentrations of Cu, Zn, Fe, or Se in the intestine, liver, and/or plasma. However, aside from Fe, the other three trace elements were only marginally modulated in an Nrf2-dependent manner. Selenium deficiency mainly resulted in increased plasma Zn levels. One putative mediator could be the metal regulatory transcription factor 1, which was up-regulated with an increasing Se supply and downregulated in Se-supplemented Nrf2 knockout mice.

Virus induces metal-binding proteins and changed trace element balance in the brain during the course of a common human infection (coxsackievirus B3) in mice

2007 ◽  
Vol 381 (1-3) ◽  
pp. 88-98 ◽  
Author(s):  
Nils-Gunnar Ilbäck ◽  
Peter Frisk ◽  
Nahla Mohamed ◽  
Inga-Lill Gadhasson ◽  
Jonas Blomberg ◽  
...  
Keyword(s):  
Trace Element ◽  
Metal Binding ◽  
Binding Proteins ◽  
Coxsackievirus B3 ◽  
Human Infection ◽  
Element Balance ◽  
The Brain

Comparison of localization of metallothionein in tissues of metallothionein-deficient mice

1995 ◽  
Vol 53 ◽  
pp. 1042-1043
Author(s):  
H. Nishimura ◽  
R Nishimura ◽  
D.L. Adelson ◽  
A.E. Michaelska ◽  
K.H.A. Choo ◽  
...  
Keyword(s):  
Metal Binding ◽  
Immunohistochemical Staining ◽  
Squamous Epithelium ◽  
Rabbit Antiserum ◽  
Slight Modification ◽  
Positive Control ◽  
Heavy Metal Binding ◽  
Critical Organ ◽  
Metal Binding Protein ◽  
Deficient Mice

Metallothionein (MT), a cysteine-rich heavy metal binding protein, has several isoforms designated from I to IV. Its major isoforms, I and II, can be induced by heavy metals like cadmium (Cd) and, are present in various organs of man and animals. Rodent testes are a critical organ to Cd and it is still a controversial matter whether MT exists in the testis although it is clear that MT is not induced by Cd in this tissue. MT-IV mRNA was found to localize within tongue squamous epithelium. Whether MT-III is present mainly glial cells or neurons has become a debatable topic. In the present study, we have utilized MT-I and II gene targeted mice and compared MT localization in various tissues from both MT-deficient mice and C57Black/6J mice (C57BL) which were used as an MT-positive control. For MT immunostaining, we have used rabbit antiserum against rat MT-I known to cross-react with mammalian MT-I and II and human MT-III. Immunohistochemical staining was conducted by the method described in the previous paper with a slight modification after the tissues were fixed in HistoChoice and embedded in paraffin.

Microanalytical Identification of a New Zr-Nb-Fe Phase

1990 ◽  
Vol 48 (2) ◽  
pp. 132-133
Author(s):  
O.T. Woo ◽  
G.J.C. Carpenter
Keyword(s):  
Trace Elements ◽  
Cold Rolling ◽  
Proportionality Factor ◽  
Tube Material ◽  
X Ray ◽  
Metal Foils ◽  
Arc Melting ◽  
Intermetallic Particles ◽  
Intermetallic Precipitates ◽  
Cold Worked

To study the influence of trace elements on the corrosion and hydrogen ingress in Zr-2.5 Nb pressure tube material, buttons of this alloy containing up to 0.83 at% Fe were made by arc-melting. The buttons were then annealed at 973 K for three days, furnace cooled, followed by ≈80% cold-rolling. The microstructure of cold-worked Zr-2.5 at% Nb-0.83 at% Fe (Fig. 1) contained both β-Zr and intermetallic precipitates in the α-Zr grains. The particles were 0.1 to 0.7 μm in size, with shapes ranging from spherical to ellipsoidal and often contained faults. β-Zr appeared either roughly spherical or as irregular elongated patches, often extending to several micrometres.The composition of the intermetallic particles seen in Fig. 1 was determined using Van Cappellen’s extrapolation technique for energy dispersive X-ray analysis of thin metal foils. The method was employed to avoid corrections for absorption and fluorescence via the Cliff-Lorimer equation: CA/CB = kAB · IA/IB, where CA and CB are the concentrations by weight of the elements A and B, and IA and IB are the X-ray intensities; kAB is a proportionality factor.

A new family of fluorescent calcium indicators designed to resist leakage or for measuring calcium near membranes

1994 ◽  
Vol 52 ◽  
pp. 168-169
Author(s):  
Martin Poenie ◽  
Akwasi Minta ◽  
Charles Vorndran
Keyword(s):  
Metal Binding ◽  
Acetoxymethyl Ester ◽  
Binding Properties ◽  
Fura 2 ◽  
New Family ◽  
Anion Transporter ◽  
Calcium Indicator ◽  
Calcium Indicators ◽  
High Calcium ◽  
Intracellular Compartmentalization

The use of fura-2 as an intracellular calcium indicator is complicated by problems of rapid dye leakage and intracellular compartmentalization which is due to a probenecid sensitive anion transporter. In addition there is increasing evidence for localized microdomains of high calcium signals which may not be faithfully reported by fura-2.We have developed a new family of fura-2 analogs aimed at addressing some of these problems. These new indicators are based on a modified bapta which can be readily derivatized to produce fura-2 analogs with a variety of new properties. The modifications do not affect the chromophore and have little impact on the spectral and metal binding properties of the indicator. One of these new derivatives known as FPE3 is a zwitterionic analog of fura-2 that can be loaded into cells as an acetoxymethyl ester and whose retention in cells is much improved. The improved retention of FPE3 is important for both cuvettebased measurements of cell suspensions and for calcium imaging.

XRMF applications of a monolithic, polycapillary, focusing x-ray optic

1996 ◽  
Vol 54 ◽  
pp. 240-241
Author(s):  
D. A. Carpenter ◽  
Ning Gao ◽  
G. J. Havrilla
Keyword(s):  
Trace Elements ◽  
Point Source ◽  
Focal Spot ◽  
Fluorescence Analysis ◽  
X Rays ◽  
Focal Distance ◽  
Spot Diameter ◽  
X Ray ◽  
Focal Spot Diameter

A monolithic, polycapillary, x-ray optic was adapted to a laboratory-based x-ray microprobe to evaluate the potential of the optic for x-ray micro fluorescence analysis. The polycapillary was capable of collecting x-rays over a 6 degree angle from a point source and focusing them to a spot approximately 40 µm diameter. The high intensities expected from this capillary should be useful for determining and mapping minor to trace elements in materials. Fig. 1 shows a sketch of the capillary with important dimensions.The microprobe had previously been used with straight and with tapered monocapillaries. Alignment of the monocapillaries with the focal spot was accomplished by electromagnetically scanning the focal spot over the beveled anode. With the polycapillary it was also necessary to manually adjust the distance between the focal spot and the polycapillary.The focal distance and focal spot diameter of the polycapillary were determined from a series of edge scans.

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