scholarly journals Key Histopathologic Features of Liver Biopsies That Distinguish Biliary Atresia From Other Causes of Infantile Cholestasis and Their Correlation With Outcome

2016 ◽  
Vol 40 (12) ◽  
pp. 1601-1615 ◽  
Author(s):  
Pierre Russo ◽  
John C. Magee ◽  
Robert A. Anders ◽  
Kevin E. Bove ◽  
Catherine Chung ◽  
...  
Keyword(s):  
Biliary Atresia ◽  
Liver Biopsies ◽  
Infantile Cholestasis ◽  
Histopathologic Features

scholarly journals Associations between Vitamin D and Liver Function and Liver Fibrosis in Patients with Biliary Atresia

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Peijun Zhuang ◽  
Song Sun ◽  
Rui Dong ◽  
Gong Chen ◽  
Yanlei Huang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Liver Fibrosis ◽  
Liver Function ◽  
Confidence Interval ◽  
Biliary Atresia ◽  
Odds Ratio ◽  
Intraoperative Cholangiography ◽  
Preoperative Serum ◽  
Histopathologic Features

Objectives. To detail the effects of vitamin D (VD) deficiency and assess the relationships between VD deficiency and liver function and liver fibrosis in patients with biliary atresia (BA). Methods. In this study, BA patients confirmed by intraoperative cholangiography were enrolled between January 2017 and February 2019. Preoperative serum 25-(OH)D level, liver function, serum biomarker levels of liver fibrosis, and histopathologic features were recorded. Deficiency, insufficiency, and sufficiency of VD were defined as serum 25-(OH)D concentrations of <10, 10-20, and >20 ng/ml, respectively. Associations between serum 25-(OH)D level and liver function and liver fibrosis were analyzed. Results. A total of 161 BA infants were included. The median (interquartile range (IQR)) serum 25-(OH)D level in all patients was 7.56 (IQR: 4.48–11.40) ng/ml. The rates of 25-(OH)D deficiency, insufficiency, and sufficiency were 67.1% (108/161), 29.2% (47/161), and 3.7% (6/161), respectively. Serum 25-(OH)D level was negatively correlated with alkaline phosphatase (r=‐0.232, P=0.003). After adjusting for age, a decrease in serum 25-(OH)D level was correlated with the increase of the Batts-Ludwig stage score (odds ratio (OR): 0.94, 95% confidence interval (CI): 0.88–0.99; P=0.028). Serum 25-(OH)D level was also correlated with the N-terminal propeptide of type III procollagen (PIIINP) (r=‐0.246, P=0.002). Additionally, PIIINP (P=0.038) and ALP (P=0.031) were independently associated with serum 25-(OH)D level. Conclusions. VD deficiency was common and inversely correlated with liver fibrosis in BA patients. Furthermore, VD was not correlated with liver function except alkaline phosphatase.

scholarly journals CD 56 staining in liver biopsies does not help in differentiating extrahepatic biliary atresia from other causes of neonatal cholestasis

2008 ◽  
Vol 3 (1) ◽  
pp. 10 ◽  
Author(s):  
Fatemeh E Mahjoub ◽  
Reza Khairkhah ◽  
Mehri Sani ◽  
Guiti Irvanloo ◽  
Maryam Monajemzadeh
Keyword(s):  
Biliary Atresia ◽  
Neonatal Cholestasis ◽  
Extrahepatic Biliary Atresia ◽  
Liver Biopsies

Cytokeratin Immunohistochemical Examination of Liver Biopsies in Infants with Alagille Syndrome and Biliary Atresia

1992 ◽  
Vol 15 (1) ◽  
pp. 73-80 ◽  
Author(s):  
W. R. Treem ◽  
G. A. Krzymowski ◽  
R. W. Cartun ◽  
C. A. Pedersen ◽  
J. S. Hyams ◽  
...  
Keyword(s):  
Biliary Atresia ◽  
Alagille Syndrome ◽  
Immunohistochemical Examination ◽  
Liver Biopsies

Histopathologic Evaluation of Feline Inflammatory Liver Disease

1996 ◽  
Vol 33 (5) ◽  
pp. 521-526 ◽  
Author(s):  
J. M. Gagne ◽  
D. J. Weiss ◽  
P. J. Armstrong
Keyword(s):  
Liver Disease ◽  
Bile Duct ◽  
Plasma Cells ◽  
University Of Minnesota ◽  
Bile Duct Proliferation ◽  
Histopathologic Evaluation ◽  
Liver Biopsies ◽  
Inflammatory Infiltrates ◽  
The University ◽  
Histopathologic Features

To better define the histopathologic features of feline inflammatory liver disease, we studied feline liver biopsies evaluated at the University of Minnesota Veterinary Teaching Hospital over a 10-year period. Of 175 liver sections examined, 45 had portal inflammatory infiltrates. Of these, 60% had infiltrates consisting of lymphocytes and plasma cells, 24% had infiltrates consisting of neutrophils, and 16% had mixed infiltrates consisting of neutrophils, lymphocytes, and plasma cells. Lymphocytic-plasmacytic portal infiltrates were characterized by various degrees of bile duct proliferation and fibrosis without evidence of bile duct infiltration or periportal necrosis. Sections with portal neutrophilic infiltrates were characterized by bile duct infiltration, bile duct epithelial degeneration, periportal necrosis, and infiltration of neutrophils into adjacent lobules. We propose that hepatitis characterized by portal lymphocyte and plasma cell infiltration be termed lymphocytic portal hepatitis and that hepatitis characterized by cholangitis and portal neutrophilic infiltrates with or without lymphocytes and plasma cells be termed cholangiohepatitis.

The extent of biliary proliferation in liver biopsies from patients with biliary atresia at portoenterostomy is associated with the postoperative prognosis

2009 ◽  
Vol 44 (4) ◽  
pp. 695-701 ◽  
Author(s):  
Jorge L. Santos ◽  
Carlos O. Kieling ◽  
Luise Meurer ◽  
Sandra Vieira ◽  
Cristina T. Ferreira ◽  
...  
Keyword(s):  
Biliary Atresia ◽  
Postoperative Prognosis ◽  
Liver Biopsies

scholarly journals DIFFERENTIATING BILIARY ATRESIA FROM OTHER CAUSES OF CHOLESTASIS JAUNDICE IN INFANTS

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Kim Oanh Bui
Keyword(s):  
Biliary Atresia ◽  
Cytomegalovirus Infection ◽  
Demographic Data ◽  
Signs And Symptoms ◽  
Neonatal Hepatitis ◽  
Bile Formation ◽  
Common Causes ◽  
Laboratory Investigations ◽  
Infantile Cholestasis ◽  
Idiopathic Neonatal Hepatitis

Aim: The aim of this study is to find out the cholestatic etiologies in infants and differences of clinical features, laboratory investigations between biliary atresia and other causes of cholestasis at Vietnam Children Hospital. Background: Cholestasis is defined as reduced bile formation or biliary flow. It results of varied causes. Early detection of biliary atresia is to intervene in time and have the best outcome. Patient and methods: In this retrospective study, 305 infants under 12 months of age with cholestasis were studied in Vietnam Children Hospital during 1/2017-7/2018. Demographic data, duration of jaundice, signs and symptoms as well as laboratory, imaging, liver biopsy and the causes of cholestasis were recorded, divided into 2 group BA and Non-BA. Results: 305 infants (194 boys, 111 girls) with cholestasis and mean age of 83,22±72,10 days were included in the study. The most common causes of cholestasis were idiopathic neonatal hepatitis (33,8%), biliary atresia (25,9%), cytomegalovirus infection (21,6%). In BA group, pale stool (100%), Hepatomegaly (98,7%);  increasing less AST, ALT, more GGT level than Non-BA. Find out GGT cutoff > 212,05 UI/l in diagnosing BA. Conclusion: Biliary atresia and idiopathic neonatal hepatitis are the most common causes of infantile cholestasis. Pale stool, hepatomegaly and GGT elevation > 212,05 UI/l are the most reliable tests for diagnosing BA.  

scholarly journals Biliary atresia: pathology, etiology and pathogenesis

2020 ◽  
Vol 6 (5) ◽  
pp. FSO466
Author(s):  
Mukul Vij ◽  
Mohamed Rela
Keyword(s):  
Biliary Atresia ◽  
Bile Flow ◽  
Biliary Tree ◽  
Giant Cells ◽  
Biliary Epithelium ◽  
Liver Biopsies ◽  
Portal Tracts ◽  
Ductular Proliferation ◽  
Th1 Immune Response ◽  
Multinucleate Giant Cells

Biliary atresia is a progressive fibrosing obstructive cholangiopathy of the intrahepatic and extrahepatic biliary system, resulting in obstruction of bile flow and neonatal jaundice. Histopathological findings in liver biopsies include the expansion of the portal tracts, with edematous fibroplasia and bile ductular proliferation, with bile plugs in duct lumen. Lobular morphological features may include variable multinucleate giant cells, bilirubinostasis and hemopoiesis. The etiopathogenesis of biliary atresia is multifactorial and multiple pathomechanisms have been proposed. Experimental and clinical studies have suggested that viral infection initiates biliary epithelium destruction and release of antigens that trigger a Th1 immune response, which leads to further injury of the bile duct, resulting in inflammation and obstructive scarring of the biliary tree. It has also been postulated that biliary atresia is caused by a defect in the normal remodelling process. Genetic predisposition has also been proposed as a factor for the development of biliary atresia.

Sign in / Sign up

Export Citation Format

Share Document