Anti-NMDA Receptor Encephalitis Associated With an Ovarian Teratoma Presenting as First-episode Psychosis: A Case Report

2022 ◽  
Vol 28 (1) ◽  
pp. 84-88
Author(s):  
Pedro Câmara-Pestana ◽  
Andreia D. Magalhães ◽  
Tiago Mendes ◽  
Pedro Levy ◽  
Ricardo Coentre
Keyword(s):  
Case Report ◽  
Nmda Receptor ◽  
First Episode Psychosis ◽  
Ovarian Teratoma ◽  
First Episode ◽  
Nmda Receptor Encephalitis ◽  
Episode Psychosis

Understanding the tests that we order: screening for anti-NMDA receptor encephalitis in first episode psychosis

2020 ◽  
Vol 28 (2) ◽  
pp. 199-201
Author(s):  
Joel Singer ◽  
Perminder Sachdev ◽  
Adith Mohan
Keyword(s):  
Nmda Receptor ◽  
Clinical Presentation ◽  
First Episode Psychosis ◽  
Clinical Suspicion ◽  
First Episode ◽  
Nmda Receptor Encephalitis ◽  
Episode Psychosis ◽  
Current Guidelines ◽  
Positive Results ◽  
Test Probability

Objective: The current guidelines recommend screening all patients with first episode psychosis (FEP) for anti-NMDA receptor encephalitis. This paper explores the pitfalls of this strategy. Conclusion: Screening for anti-NMDA receptor encephalitis in patients with FEP when the pre-test probability based on the clinical presentation is low creates a risk of false positive results. Testing based on clinical suspicion would be preferable.

scholarly journals Paliperidone induced neutropenia in first episode psychosis: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Natalie Martos ◽  
William Hall ◽  
Alicia Marhefka ◽  
Thomas W. Sedlak ◽  
Frederick C. Nucifora
Keyword(s):  
Adverse Effect ◽  
Case Report ◽  
The United States ◽  
First Episode Psychosis ◽  
Potential Adverse Effect ◽  
Severe Neutropenia ◽  
First Episode ◽  
Antipsychotic Medications ◽  
Increased Risk ◽  
Episode Psychosis

Abstract Background Neutropenia, a decrease in total number of neutrophils below 1500/mm3 and particularly severe neutropenia, defined as neutrophils less than 500/mm3, is a potential adverse effect of antipsychotic medications that can lead to increased risk of infections and death. However, much of the attention on the potential adverse effect is centered exclusively on clozapine, which remains the only antipsychotic medication in the United States requiring standardized monitoring of blood work. We demonstrate here that paliperidone can also cause neutropenia and therefore clinicians should be aware of this possibility especially during initiation of treatment. Case presentation The following report presents the case of a 23-year-old African American male with first episode psychosis who developed neutropenia after initiation of paliperidone. Neutropenia resolved after discontinuation of paliperidone and initiation of an alternative antipsychotic, haloperidol. Conclusions This case report demonstrates an example of paliperidone induced neutropenia which resolved with a switch to haloperidol. We conclude that when initiating paliperidone, clinicians should be more aware of the risk of neutropenia. Moreover, neutropenia may be a more common and overlooked issue in patients on antipsychotic medications other than clozapine and increased awareness of comparative risk across antipsychotics could help direct treatment.

scholarly journals Early onset first-episode psychosis during treatment with thalidomide for refractory ulcerative colitis: a case report

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Maria Giuseppina Petruzzelli ◽  
Lucia Margari ◽  
Sara Ivagnes ◽  
Roberto Palumbi ◽  
Francesco Margari
Keyword(s):  
Ulcerative Colitis ◽  
Case Report ◽  
Early Onset ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis

P.071 Associations between genetic variants of NMDA receptor genes and first episode psychosis in a Brazilian sample

2019 ◽  
Vol 29 ◽  
pp. S68
Author(s):  
C. Loureiro ◽  
H.A. Fachim ◽  
F. Corsi-Zuelli ◽  
P.R. Menezes ◽  
C.F. Dalton ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Genetic Variants ◽  
First Episode Psychosis ◽  
First Episode ◽  
Brazilian Sample ◽  
Episode Psychosis
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