Increased Liver and Spleen Accumulation of Tc-99m Methylene Diphosphonate Associated With Intravenous Injection of MRI Contrast Gadolinium-Diethylenetriaminepentaacetic Acid

2011 ◽  
Vol 36 (3) ◽  
pp. 183-185 ◽  
Author(s):  
Weifang Zhang ◽  
Yanyan Zhang ◽  
Xinxin Li ◽  
Zhonghui Jin
Keyword(s):  
Intravenous Injection ◽  
Diethylenetriaminepentaacetic Acid ◽  
Mri Contrast ◽  
Methylene Diphosphonate

scholarly journals Contrast Enhancement of the Brain by Folate-Conjugated Gadolinium–Diethylenetriaminepentaacetic Acid–Human Serum Albumin Nanoparticles by Magnetic Resonance Imaging

2012 ◽  
Vol 11 (4) ◽  
pp. 7290.2011.00047 ◽  
Author(s):  
Huedayi Korkusuz ◽  
Karsten Ulbrich ◽  
Verena Bihrer ◽  
Katerina Welzel ◽  
Valery Chernikov ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Contrast Agents ◽  
Diethylenetriaminepentaacetic Acid ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
The Brain ◽  
Signal Intensities

Different from regular small molecule contrast agents, nanoparticle-based contrast agents have a longer circulation time and can be modified with ligands to confer tissue-specific contrasting properties. We evaluated the tissue distribution of polymeric nanoparticles (NPs) prepared from human serum albumin (HSA), loaded with gadolinium–diethylenetriaminepentaacetic acid (Gd-DTPA) (Gd-HSA-NP), and coated with folic acid (FA) (Gd-HSA-NP-FA) in mice by magnetic resonance imaging (MRI). FA increases the affinity of the Gd-HSA-NP to FA receptor–expressing cells. Clinical 3 T MRI was used to evaluate the signal intensities in the different organs of mice injected with Gd-DTPA, Gd-HSA-NP, or Gd-HSA-NP-FA. Signal intensities were measured and standardized by calculating the signal to noise ratios. In general, the NP-based contrast agents provided stronger contrasting than Gd-DTPA. Gd-HSA-NP-FA provided a significant contrast enhancement (CE) in the brain ( p = .0032), whereas Gd-DTPA or Gd-HSA-NP did not. All studied MRI contrast agents showed significant CE in the blood, kidney, and liver ( p < .05). Gd-HSA-NP-FA elicited significantly higher CE in the blood than Gd-HSA-NP ( p = .0069); Gd-HSA-NP and Gd-HSA-NP-FA did not show CE in skeletal muscle and gallbladder; Gd-HSA-NP, but not Gd-HSA-NP-FA, showed CE in the cardiac muscle. Gd-HSA-NP-FA has potential as an MRI contrast agent in the brain.

The behavior after intravenous injection in mice of multiwalled carbon nanotube / Fe3O4 hybrid MRI contrast agents

Biomaterials ◽  
2011 ◽  
Vol 32 (21) ◽  
pp. 4867-4876 ◽  
Author(s):  
Huixia Wu ◽  
Gang Liu ◽  
Yeming Zhuang ◽  
Dongmei Wu ◽  
Haoqiang Zhang ◽  
...  
Keyword(s):  
Carbon Nanotube ◽  
Contrast Agents ◽  
Intravenous Injection ◽  
Mri Contrast Agents ◽  
Multiwalled Carbon Nanotube ◽  
Multiwalled Carbon ◽  
Mri Contrast

Gadolinium complexes of chlorin derivatives applicable for MRI contrast agents and PDT

2009 ◽  
Vol 13 (07) ◽  
pp. 823-831 ◽  
Author(s):  
Oyunbileg Galindev ◽  
Monkhoobor Dalantai ◽  
Woong Shick Ahn ◽  
Young Key Shim
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cancer Diagnosis ◽  
High Sensitivity ◽  
Mri Contrast Agents ◽  
Diethylenetriaminepentaacetic Acid ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Pyropheophorbide A ◽  
Magnetic Resonance Imaging Mri ◽  
Tumor Selective

One of the ultimate goals of contrast agent (CA) research in magnetic resonance imaging (MRI) is to identify tumor-seeking materials. Thus, cancer diagnosis by Photodynamic Therapy (PDT) using photosensitizer will be one of the best tools for cancer research. By linking paramagnetic gadolinium [ Gd(III) ] ion to tumor selective chlorin-based photosensitizers, the cancer cell can be easily detected with high sensitivity and cured by appropriate laser irradiation simultaneously. The synthesis of monomer and dimer chlorin derivatives, such as pyropheophorbide-a and purpurin systems, conjugated with Gd(III) diethylenetriaminepentaacetic acid (DTPA) by means of diethylene-triaminepentaacetic dianhydride (caDTPA) for the evaluation as CAs for MRI was described in the present study.

The Local Sanarelli-Shwartzman Phenomenon in Rats Induced by Human Leukaemic Cells

1973 ◽  
Vol 29 (02) ◽  
pp. 353-362
Author(s):  
J Lisiewicz ◽  
A Pituch ◽  
J. A Litwin
Keyword(s):  
Chronic Lymphocytic Leukaemia ◽  
Intravenous Injection ◽  
Peripheral Blood ◽  
Lymphocytic Leukaemia ◽  
Acute Myeloblastic Leukaemia ◽  
Demarcation Line ◽  
E Coli ◽  
Leukaemic Cells ◽  
Shwartzman Phenomenon

SummaryThe local Sanarelli-Shwartzman phenomenon (SSP-L) in the skin of 30 rats was induced by an intr a cutaneous sensitizing injection of leukaemic leucocytes isolated from the peripheral blood of patients with chronic lymphocytic leukaemia (CLL), acute myeloblastic leukaemia (AL) and chronic granulocytic leukaemia (CGL) and challenged by an intravenous injection of 100(μ of E. coli endotoxin. SSP-L was observed in 7 rats after injection of CLL lymphocytes and in 6 and 2 rats after AL myeloblasts and the CGL granulocytes, respectively. The lesions in the skin after AL myeloblasts appeared in a shorter time and were of longer duration compared with those observed after CLL lymphocytes and CGL granulocytes. Histologically, the lesions consisted of areas of destruction in the superficial layers of the skin ; the demarcation line showed the presence of neutrophils, macrophages and erythrocytes. Haemorrhages and fibrin deposits near the demarcation line were larger after injection of CLL lymphocytes and AL myeloblasts than after CGL granulocytes. The possible role of leucocyte procoagulative substances in the differences observed have been discussed.

Ultrastructural Changes of the Tissue Thromboplastin after Intravenous Injection in Rabbits

1978 ◽  
Vol 39 (01) ◽  
pp. 201-209 ◽  
Author(s):  
Hiroshi Hasegawa ◽  
Hiroshi Nagata ◽  
Makoto Murao
Keyword(s):  
Intravenous Injection ◽  
Vascular Endothelium ◽  
Model Experiment ◽  
Venous Return ◽  
Ultrastructural Changes ◽  
Membrane Structures ◽  
Tissue Thromboplastin ◽  
Short Time ◽  
Sheet Membrane

SummaryAttempts were made to demonstrate ultrastructural changes of the tissue thromboplastin after intravenous injection, as a model experiment on the pulmonary microthrombi formation induced by the tissue thromboplastin circulating from venous return.Concentrically arranged membrane structures of the injected thromboplastin disappeared in extremely short time after the injection of the thromboplastin in rabbits. The long sheet membrane of the injected thromboplastin was frequently seen as adhered to the vascular endothelium or to the surface of blood corpuscles. Furthermore, fibrin fibres were formed in contact with the long sheet membrane of the thromboplastin. Membrane structures were not found anywhere in the control rabbits.

Turnover of Human Extrinsic (Tissue-Type) Plasminogen Activator in Rabbits

1981 ◽  
Vol 46 (03) ◽  
pp. 658-661 ◽  
Author(s):  
C Korninger ◽  
J M Stassen ◽  
D Collen
Keyword(s):  
Plasminogen Activator ◽  
Intravenous Injection ◽  
Active Site ◽  
Half Life ◽  
Degradation Products ◽  
Gel Filtration ◽  
Tissue Type ◽  
Organ Distribution ◽  
Small Rise

SummaryThe turnover of highly purified human extrinsic plasminogen activator (EPA) (one- and two-chain form) was studied in rabbits. Following intravenous injection, EPA-activity declined rapidly. The disappearance rate of EPA from the plasma could adequately be described by a single exponential term with a t ½ of approximately 2 min for both the one-chain and two-chain forms of EPA.The clearance and organ distribution of EPA was studied by using 125I-labeled preparations. Following intravenous injection of 125I-1abeled EPA the radioactivity disappeared rapidly from the plasma also with a t ½ of approximately 2 min down to a level of 15 to 20 percent, followed by a small rise of blood radioactivity. Gel filtration of serial samples revealed that the secondary increase of the radioactivity was due to the reappearance of radioactive breakdown products in the blood. Measurement of the organ distribution of 125I at different time intervals revealed that EPA was rapidly accumulated in the liver, followed by a release of degradation products in the blood.Experimental hepatectomy markedly prolonged the half-life of EPA in the blood. Blocking the active site histidine of EPA had no effect on the half-life of EPA in blood nor on the gel filtration patterns of 125I in serial plasma samples.It is concluded that human EPA is rapidly removed from the blood of rabbits by clearance and degradation in the liver. Recognition by the liver does not require a functional active site in the enzyme. Neutralization in plasma by protease inhibitors does not represent a significant pathway of EPA inactivation in vivo.

Inhibition of Fibrinoid Deposition by Heparin

1961 ◽  
Vol 06 (01) ◽  
pp. 157-159 ◽  
Author(s):  
Saul B. Gilson
Keyword(s):  
Intravenous Injection ◽  
Gamma Globulin ◽  
Physiological Significance

ConclusionExperimental glomerulitis in rabbits following intravenous injection of gamma globulin was inhibited by heparinization. The physiological and patho-physiological significance of this observation is considered.

Sign in / Sign up

Export Citation Format

Share Document