Postradiation Optic Atrophy Is Associated With Intraocular Pressure and May Manifest With Neuroretinal Rim Thinning

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Lauren A. Dalvin ◽  
Christopher L. Deufel ◽  
Kimberly S. Corbin ◽  
Ivy A. Petersen ◽  
Timothy W. Olsen ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Optic Atrophy ◽  
Neuroretinal Rim

Short-Wavelength Automated Perimetry and Neuroretinal Rim Area

2000 ◽  
Vol 10 (2) ◽  
pp. 116-120 ◽  
Author(s):  
J.M. Larrosa ◽  
V. Polo ◽  
L. Pablo ◽  
I. Pinilla ◽  
F.J. Fernandez ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Visual Field ◽  
Short Wavelength ◽  
Selection Criteria ◽  
Visual Fields ◽  
Automated Perimetry ◽  
Neuroretinal Rim ◽  
Humphrey Field Analyzer ◽  
Neuroretinal Rim Area

Purpose To determine the correlation between neuroretinal rim area and functional losses detected by short-wavelength automated perimetry (SWAP) in a population of patients with suspected glaucoma. Methods Forty-two eyes of 42 ocular hypertensive subjects who met the selection criteria (intraocular pressure greater than 21 mm of Hg and normal conventional visual fields) were studied. A planimetric optic nerve head study was performed, determining the total and sectorized neuroretinal rim areas. SWAP was also done, with a modified Humphrey field analyzer. Results There were no significant correlations between the neuroretinal rim areas and the global perimetric parameters. However, the correlations between the inferotemporal neuroretinal rim area and some superonasal visual field regions (areas 3 and 4) were significant. Conclusions There is a relation in the topography of some visual field areas assessed by SWAP and the inferotemporal neuroretinal rim area, which may play a role in the diagnosis and follow-up of suspected glaucoma.

scholarly journals Neuroretinal rim response to transient changes in intraocular pressure in healthy non-human primate eyes

2020 ◽  
Vol 193 ◽  
pp. 107978 ◽  
Author(s):  
Laura P. Pardon ◽  
Ronald S. Harwerth ◽  
Nimesh B. Patel
Keyword(s):  
Intraocular Pressure ◽  
Neuroretinal Rim ◽  
Human Primate

Effect of acute intraocular pressure elevation on the minimum rim width in normal, ocular hypertensive and glaucoma eyes

2017 ◽  
Vol 102 (1) ◽  
pp. 131-135 ◽  
Author(s):  
Sourabh Sharma ◽  
Tin A Tun ◽  
Mani Baskaran ◽  
Eray Atalay ◽  
Sri Gowtham Thakku ◽  
...  
Keyword(s):  
New York ◽  
Intraocular Pressure ◽  
Connective Tissues ◽  
Neuroretinal Rim ◽  
Applanation Tonometer ◽  
Intraocular Pressure Elevation ◽  
Iop Elevation ◽  
Significant Change ◽  
Primary Glaucoma ◽  
Normal Controls

BackgroundTo estimate and compare changes in the Bruch’s membrane opening—minimum rim width (BMO–MRW) and area in normal, ocular hypertensive and glaucoma eyes following acute elevations in intraocular pressure (IOP).MethodsThe optic nerve heads (ONHs) of 104 subjects (31 normals, 20 ocular hypertension (OHT) and 53 with primary glaucoma) were imaged using Spectral-domain optical coherence tomography (OCT; Spectralis, Heidelberg Engineering, Germany). IOP was raised twice by applying a force (0.64 n then 0.9 n) to the anterior sclera using an ophthalmo-dynamometer. After each IOP increment, IOP was held constant, measured with a Tonopen (AVIA applanation tonometer, Reichert, Depew, New York, USA), and ONH was rescanned with OCT. In each OCT volume, BMO–MRW and area were calculated and at each IOP increment.ResultsThe baseline MRW was significantly smaller in glaucoma subjects (174.3±54.3 µm) compared with normal (287.4±42.2 µm, p<0.001) and OHT subjects (255.4±45.3 µm, p<0.001). MRW of glaucoma subjects was significantly thinner at the first and second IOP elevations than that at baseline (both p<0.01), but no significant change was noted in normal and OHT subjects. There was no significant change of BMO area at acute IOP elevations from baseline in all diagnoses (all p>0.05).ConclusionAcute IOP elevation leads to compression of the nerve fibre layers of neuroretinal rim in glaucoma subjects only without changing ONH size. This suggests that the neural and connective tissues at ONH level in glaucoma subjects are more susceptible to acute IOP episodes than OHT or normal controls.

Ahmed Valve Implantation in an Eye with Choroidal Haemangioma

1970 ◽  
Vol 12 (3) ◽  
pp. 169-171
Author(s):  
Norshamsiah Md Din ◽  
Lee M Yueh ◽  
Sumugam S Kala ◽  
Ropilah A Rahman
Keyword(s):  
Intraocular Pressure ◽  
Venous Pressure ◽  
Postoperative Recovery ◽  
Antiglaucoma Medication ◽  
Neuroretinal Rim ◽  
Ahmed Valve ◽  
Weber Syndrome ◽  
Advanced Glaucoma ◽  
The Right ◽  
Valve Implantation

Sturge Weber syndrome is a rare phakomatoses characterised by vascular hamartomas affecting the leptomeninges, and cutaneous and ocular structures. Glaucoma results from angle anomalies, overproductionfrom ciliary body haemangioma, or reduction in aqueous outflow secondary to increased episcleral venous pressure. The presence of a choroidal haemangioma in an eye with advanced glaucoma adds to the complicated postoperative recovery. This report is of a 9-year-old girl with a right-sided facial naevus flammeus who was referred for advanced glaucoma in the right eye. The eye was buphthalmic, her intraocular pressure was 25 mm Hg while using 4 topical antiglaucoma medications, and the visual acuity was 6/36. The optic disc had advanced cupping with a pale neuroretinal rim. Her visual field was severely constricted with fixation splitting. She underwent Ahmed valve implantation with controlled filtration via nylon stenting of the tube. Her postoperative recovery was complicated, and she needed further ligation of the tube to reduce drainage. Six weeks later, her intraocular pressure was controlled at 14 mm Hg without any antiglaucoma medication after removal of the nylon stent. Managing an eye with advanced glaucoma in the presence of a choroidal haemangioma needs meticulous controlled drainage to prevent detrimental postoperative complications.

The neuroretinal rim in descending optic atrophy

1992 ◽  
Vol 230 (2) ◽  
pp. 154-157 ◽  
Author(s):  
Stephen M. Drance ◽  
Deen King
Keyword(s):  
Optic Atrophy ◽  
Neuroretinal Rim

scholarly journals Cardiac and ocular manifestations in Egyptian patients with mucopolysaccharidoses

2001 ◽  
Vol 7 (06) ◽  
pp. 981-991 ◽  
Author(s):  
R. M. Shawky ◽  
M. T. Abdel Monim ◽  
A. A. El Sebai ◽  
S. M. El Sayed
Keyword(s):  
Intraocular Pressure ◽  
Mitral Valve ◽  
Optic Atrophy ◽  
Progressive Increase ◽  
Fundus Examination ◽  
Ocular Manifestations ◽  
Egyptian Patients ◽  
Corneal Opacities ◽  
Bilateral Papilloedema

Cardiac and ocular manifestations were evaluated in 21 patients clinically suspected of mucopolysaccharidosis. After electrophoresis analysis of urinary glycoaminoglycans, 3 patients were excluded because their results did not correlate with any known type of mucopolysaccharidosis. Echocardiography revealed abnormal findings in 11 patients [61.1%]. The mitral valve was the most commonly affected valve; 7 patients [38.9%] had thickened mitral valve and 6 had mitral regurge. Corneal opacities were found in 3 patients [16.7%] and progressive increase in intraocular pressure in 1 patient [5.6%], while fundus examination showed early optic atrophy in 1 patient [5.6%] and bilateral papilloedema in 2 patients [11.1%].

scholarly journals Successful management of intralenticular Ozurdex injection causing cataract and intractable glaucoma

2020 ◽  
Vol 17 (2) ◽  
pp. 216-221
Author(s):  
Kalpa Negiloni ◽  
Ronnie Jacob George ◽  
Sridharan Sudharshan ◽  
Shwetha Tripathi
Keyword(s):  
Visual Acuity ◽  
Intraocular Pressure ◽  
Anterior Chamber ◽  
Mitomycin C ◽  
Optic Atrophy ◽  
Vision Loss ◽  
Successful Management ◽  
Implantation Procedure ◽  
Intractable Glaucoma ◽  
Uncommon Complication

A 50-year-old female presented with profound vision loss and was previously advised injection Ozurdex in the left eye. In the left eye, the anterior chamber was quiet, intraocular pressure (IOP) was 58 mmHg and cataractous changes were noted with Ozurdex implant inside the lens substance. The left eye had glaucomatous cupping (0.9:1 CDR), bipolar rim thinning, inferior notch and healed choroiditis. The patient underwent phacoemulsification, trabeculectomy and mitomycin-C in the left eye. Visual acuity improved and IOP was under control. Although Ozurdex is effective, there are reports of complications related to the drug and implantation procedure. This case highlights an uncommon complication of an uncontrolled, persistent steroid response leading to glaucomatous optic atrophy and profound vision loss due to an accidental intralenticular implantation of Ozurdex. Our case reinforces the need for caution about the decision regarding the judicious use of intravitreal steroids and employment of appropriate technique.

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