Brain Data in Pediatric Disorders of Consciousness

Journal of Clinical Neurophysiology ◽

10.1097/wnp.0000000000000772 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Fatima Y. Ismail ◽

Ghazala T. Saleem ◽

Milos R. Ljubisavljevic

Keyword(s):

Disorders Of Consciousness ◽

Brain Data ◽

Pediatric Disorders

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International survey on diagnostic and prognostic procedures in pediatric disorders of consciousness

Brain Injury ◽

10.1080/02699052.2019.1565899 ◽

2019 ◽

Vol 33 (4) ◽

pp. 517-528 ◽

Cited By ~ 1

Author(s):

Erika Molteni ◽

Beth S. Slomine ◽

Enrico Castelli ◽

Nathan Zasler ◽

Caroline Schnakers ◽

...

Keyword(s):

Disorders Of Consciousness ◽

International Survey ◽

Pediatric Disorders

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A systematic review and meta-analysis of the relationship between brain data and the outcome in Disorders of Consciousness

10.31234/osf.io/5rvdc ◽

2018 ◽

Author(s):

Yuri Pavlov

Keyword(s):

Meta Analysis ◽

Empirical Studies ◽

Minimally Conscious State ◽

Conscious State ◽

Disorders Of Consciousness ◽

Neurophysiological Data ◽

Oscillatory Eeg ◽

Improvement Criterion ◽

Brain Data ◽

Minimally Conscious

A systematic search revealed 68 empirical studies of neurophysiological (EEG, ERP, fMRI, PET) variables as potential outcome predictors in patients with Disorders of Consciousness (diagnoses Unresponsive Wakefulness Syndrome [UWS] and Minimally Conscious State [MCS]). Data of 47 publications could be presented in a quantitative manner and systematically reviewed. Insufficient power and the lack of an appropriate description of patient selection each characterized about a half of all publications. In more than 80% studies, neurologists who evaluated the patients’ outcome were familiar with the results of neurophysiological tests conducted before, and may, therefore, have been influenced by this knowledge. In most subsamples of data sets effect size significantly correlated with its standard error, indicating publication bias toward positive results. Neurophysiological data predicted the transition from UWS to MCS substantially better than they predicted the recovery of consciousness (i.e., the transition from UWS or MCS to exit-MCS). A meta-analysis was carried out for predictor groups including at least three independent studies with N > 10 per predictor per improvement criterion (i.e., transition to MCS versus recovery). Oscillatory EEG responses were the only predictor group whose effect attained significance for both improvement criteria. Other perspective variables, whose true prognostic value should be explored in future studies, are sleep spindles in the EEG and the somatosensory cortical response N20. Contrary to what could be expected on the basis of neuroscience theory, the poorest prognostic effects were shown for fMRI responses to stimulation and for the ERP component P300. The meta-analytic results should be regarded as preliminary given the presence of numerous biases in the data.

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