Magnetic resonance imaging of amyloid plaques using hollow manganese oxide nanoparticles conjugated with antibody aβ1–40 in a transgenic mouse model

Neuroreport ◽  
2013 ◽  
Vol 24 (1) ◽  
pp. 16-21 ◽  
Author(s):  
Jae-Hun Kim ◽  
Tae Lin Ha ◽  
Geun Ho Im ◽  
Jehoon Yang ◽  
Sang Won Seo ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Mouse Model ◽  
Manganese Oxide ◽  
Transgenic Mouse ◽  
Amyloid Plaques ◽  
Transgenic Mouse Model ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Manganese Oxide Nanoparticles

scholarly journals Polydopamine coated manganese oxide nanoparticles with ultrahigh relaxivity as nanotheranostic agents for magnetic resonance imaging guided synergetic chemo-/photothermal therapy

2016 ◽  
Vol 7 (11) ◽  
pp. 6695-6700 ◽  
Author(s):  
Xing Ding ◽  
Jianhua Liu ◽  
Junqi Li ◽  
Fan Wang ◽  
Yinghui Wang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Manganese Oxide ◽  
Photothermal Therapy ◽  
Oxide Nanoparticles ◽  
Core Shell ◽  
Resonance Imaging ◽  
Manganese Oxide Nanoparticles ◽  
Mri Guided

A multifunctional core/shell nanotheranostic platform was constructed which could offer MRI guided combinational chemotherapy and photothermal therapy for cancer.

scholarly journals Magnetic resonance imaging of disease progression and resolution in a transgenic mouse model of pulmonary fibrosis

2017 ◽  
Vol 312 (4) ◽  
pp. L488-L499 ◽  
Author(s):  
Zackary I. Cleveland ◽  
Yu M. Zhou ◽  
Teckla G. Akinyi ◽  
R. Scott Dunn ◽  
Cynthia R. Davidson ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Pulmonary Fibrosis ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Lung Fibrosis ◽  
Transgenic Mouse Model ◽  
High Signal ◽  
Resonance Imaging ◽  
Fibrosis Progression

Pulmonary fibrosis contributes to morbidity and mortality in a range of diseases, and there are no approved therapies for reversing its progression. To understand the mechanisms underlying pulmonary fibrosis and assess potential therapies, mouse models are central to basic and translational research. Unfortunately, metrics commonly used to assess murine pulmonary fibrosis require animals to be grouped and euthanized, increasing experimental difficulty and cost. We examined the ability of magnetic resonance imaging (MRI) to noninvasively assess lung fibrosis progression and resolution in a doxycycline (Dox) regulatable, transgenic mouse model that overexpresses transforming growth factor-α (TGF-α) under control of a lung-epithelial-specific promoter. During 7 wk of Dox treatment, fibrotic lesions were readily observed as high-signal tissue. Mean weighted signal and percent signal volume were found to be the most robust MRI-derived measures of fibrosis, and these metrics correlated significantly with pleural thickness, histology scores, and hydroxyproline content ( R = 0.75–0.89). When applied longitudinally, percent high signal volume increased by 1.5% wk−1 ( P < 0.001) and mean weighted signal increased at a rate of 0.0065 wk−1 ( P = 0.0062). Following Dox treatment, lesions partially resolved, with percent high signal volume decreasing by −3.2% wk−1 ( P = 0.0034) and weighted mean signal decreasing at −0.015 wk−1 ( P = 0.0028). Additionally, longitudinal MRI revealed dynamic remodeling in a subset of lesions, a previously unobserved behavior in this model. These results demonstrate MRI can noninvasively assess experimental lung fibrosis progression and resolution and provide unique insights into its pathobiology.

scholarly journals Relaxivity and toxicological properties of manganese oxide nanoparticles for MRI applications

RSC Advances ◽  
2016 ◽  
Vol 6 (51) ◽  
pp. 45462-45474 ◽  
Author(s):  
Benedict You Wei Hsu ◽  
Georgia Kirby ◽  
Aaron Tan ◽  
Alexander M. Seifalian ◽  
Xu Li ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Manganese Oxide ◽  
Water Permeability ◽  
High Performance ◽  
High Water ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Manganese Oxide Nanoparticles

Hollow MnO morphology and high water permeability of shell coating for high performance magnetic resonance imaging.

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