scholarly journals Protective Effect of Lipoteichoic Acid from Lactobacillus casei and Lactobacillus fermentum against Pseudomonas aeruginosa in Mice

Microbiology ◽  
1985 ◽  
Vol 131 (9) ◽  
pp. 2501-2503 ◽  
Author(s):  
T. SETOYAMA ◽  
K. NOMOTO ◽  
T. YOKOKURA ◽  
M. MUTAI
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Protective Effect ◽  
Lactobacillus Casei ◽  
Lipoteichoic Acid ◽  
Lactobacillus Fermentum

scholarly journals Protective effect of Lactobacillus casei on Pseudomonas aeruginosa infection in mice.

1985 ◽  
Vol 48 (2) ◽  
pp. 480-485 ◽  
Author(s):  
S Miake ◽  
K Nomoto ◽  
T Yokokura ◽  
Y Yoshikai ◽  
M Mutai ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Protective Effect ◽  
Lactobacillus Casei ◽  
Pseudomonas Aeruginosa Infection

Effect of Lactobacillus casei and Yogurt Administration on Prevention of Pseudomonas aeruginosa Infection in Young Mice

2001 ◽  
Vol 64 (11) ◽  
pp. 1768-1774 ◽  
Author(s):  
SUSANA ALVAREZ ◽  
CLAUDIA HERRERO ◽  
ELENA BRU ◽  
GABRIELA PERDIGON
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Oral Administration ◽  
Lactobacillus Casei ◽  
Opportunistic Pathogen ◽  
Lung Infection ◽  
Pseudomonas Aeruginosa Infection ◽  
Dose Dependent ◽  
Chronic Pneumonia ◽  
Dose Dependent Effect ◽  
Young Mice

Pseudomonas aeruginosa is an opportunistic pathogen that rarely causes pulmonary disease in normal hosts but one that is an important cause of acute pneumonia in immunocompromised patients, including neonates, and of chronic pneumonia in patients with cystic fibrosis. The aim of this work was to study the effect of oral administration of Lactobacillus casei and yogurt on prevention of P. aeruginosa lung infection in young mice (3 weeks old). This study demonstrates that oral administration of L. casei or yogurt to young mice enhanced lung clearance of P. aeruginosa and phagocytic activity of alveolar macrophages through a dose-dependent effect. There were, however, no significant differences in white blood cell (WBC) differential counts. Furthermore, it was observed that previous administration of L. casei or yogurt induced a significant increase in IgA and IgM levels in bronchoalveolar lavages (BALs) after a P. aeruginosa infection, although there was no relationship with the serum values.

scholarly journals Avaliação do efeito antiparasitário de probióticos em primatas do velho mundo mantidos em cativeiro no Zoológico Municipal de Volta Redonda - RJ

2014 ◽  
Vol 9 (26) ◽  
pp. 123
Author(s):  
Carlos Alberto Sanches Pereira ◽  
Mayara De Souza Costa
Keyword(s):  
Lactobacillus Acidophilus ◽  
Lactobacillus Casei ◽  
Lactobacillus Fermentum

As doenças em animais de cativeiro vêm apresentando um aumento expressivo, principalmente relacionada ao manejo inadequado, representando um ambiente propício à sua disseminação. Em conseqüência desses fatores há muitos distúrbios na microbiota normal do animal alterando o equilíbrio intestinal. Corroborando para as desvantagens ligadas ao efeito antiparasitário de vermífugos e antibióticos, atualmente os probióticos são considerados ferramentas alternativas no tratamento e na prevenção das diarréias, pois contêm micro-organismos benéficos que ajudam a suprimir os patógenos. Analisando-se o prisma das vantagens que os probióticos proporcionam o presente trabalho teve como objetivo a avaliação do efeito antiparasitário de probióticos a base de lactobacilos em primatas do velho mundo mantidos em cativeiro no Zoológico Municipal de Volta Redonda, RJ. Os primatas Macaco rhesus, Babuíno sagrado e Babuíno sagrado fêmea receberam diariamente 10 ml de preparado com 109 UFC/mL do Lactobacillus casei ATCC 7469, Lactobcillus plantarum ATCC 8014, Lactobacillus fermentum ATCC 9338 e Lactobacillus acidophilus ATCC 7469 na forma de “pool”, em condições assépticas, num período de 135 dias sendo administrado junto ao pão com mel, para melhor sabor junto aos primatas, 30 minutos antes da dieta diária de cada animal. Para a análise de diminuição de parasitas foi realizada exames parasitológicos quantitativos utilizando a técnica de McMaster para a contagem de ovos por grama de fezes (OPG), sendo realizada a coleta a cada 15 dias. Todos os primatas apresentaram-se parasitados por Trichirus trichiura. Após análise dos resultados de ovos por grama de fezes verificou-se que houve redução significativa de 55,1% e 53,6% dos ovos nas fezes após 135 dias com o uso do preparado probiótico diariamente, apresentando uma eficácia máxima.

scholarly journals Combined Antibacterial and Anti-Inflammatory Activity of a Cationic Disubstituted Dexamethasone-Spermine Conjugate

2010 ◽  
Vol 54 (6) ◽  
pp. 2525-2533 ◽  
Author(s):  
Robert Bucki ◽  
Katarzyna Leszczyńska ◽  
Fitzroy J. Byfield ◽  
David E. Fein ◽  
Esther Won ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Bacterial Infections ◽  
Glucocorticoid Receptors ◽  
Fluorescent Protein ◽  
Lipoteichoic Acid ◽  
Bacterial Strains ◽  
Bacterial Killing ◽  
Antibiotic Resistant ◽  
Anti Inflammatory ◽  
Green Fluorescent

ABSTRACT The rising number of antibiotic-resistant bacterial strains represents an emerging health problem that has motivated efforts to develop new antibacterial agents. Endogenous cationic antibacterial peptides (CAPs) that are produced in tissues exposed to the external environment are one model for the design of novel antibacterial compounds. Here, we report evidence that disubstituted dexamethasone-spermine (D2S), a cationic corticosteroid derivative initially identified as a by-product of synthesis of dexamethasone-spermine (DS) for the purpose of improving cellular gene delivery, functions as an antibacterial peptide-mimicking molecule. This moiety exhibits bacterial killing activity against clinical isolates of Staphylococcus aureus, Pseudomonas aeruginosa present in cystic fibrosis (CF) sputa, and Pseudomonas aeruginosa biofilm. Although compromised in the presence of plasma, D2S antibacterial activity resists the proteolytic activity of pepsin and is maintained in ascites, cerebrospinal fluid, saliva, and bronchoalveolar lavage (BAL) fluid. D2S also enhances S. aureus susceptibility to antibiotics, such as amoxicillin (AMC), tetracycline (T), and amikacin (AN). Inhibition of interleukin-6 (IL-6) and IL-8 release from lipopolysaccharide (LPS)- or lipoteichoic acid (LTA)-treated neutrophils in the presence of D2S suggests that this molecule might also prevent systemic inflammation caused by bacterial wall products. D2S-mediated translocation of green fluorescent protein (GFP)-labeled glucocorticoid receptor (GR) in bovine aorta endothelial cells (BAECs) suggests that some of its anti-inflammatory activities involve engagement of glucocorticoid receptors. The combined antibacterial and anti-inflammatory activities of D2S suggest its potential as an alternative to natural CAPs in the prevention and treatment of some bacterial infections.

scholarly journals Immunomodulating effect of fosfomycin on gut-derived sepsis caused by Pseudomonas aeruginosa in mice.

1997 ◽  
Vol 41 (2) ◽  
pp. 308-313 ◽  
Author(s):  
T Matsumoto ◽  
K Tateda ◽  
S Miyazaki ◽  
N Furuya ◽  
A Ohno ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Survival Rate ◽  
Protective Effect ◽  
Specific Activity ◽  
Bacterial Colonization ◽  
Interleukin 1 ◽  
Protective Mechanism ◽  
Protective Effects ◽  
Bacterial Clearance ◽  
Necrosis Factor Alpha

We evaluated the protective effect of fosfomycin (FOM) and an enantiomer of fosfomycin [FOM (+); an isomer of FOM with no bactericidal activity] on murine gut-derived sepsis caused by Pseudomonas aeruginosa. Endogenous bacteremia was induced by administering cyclophosphamide (CY) and ampicillin to specific-pathogen-free mice fed P. aeruginosa. Treatment of mice with FOM at 250 mg/kg of body weight per day twice a day after the second CY administration significantly increased the survival rate compared to that for control mice treated with saline. Treatment with FOM (+) at 20 and 100 mg/kg also significantly increased the survival rate (from 30% for control mice to 80% for treated mice). The bacterial counts in the liver and blood were both significantly lower in FOM(+)-treated mice in comparison with those in liver and blood of saline-treated control mice. FOM(+) administration affected neither the bacterial colonization in the intestinal tract nor the leukocyte counts in the peripheral blood of the mice. After intravascular inoculation of P. aeruginosa, treatment of mice with FOM (+) did not enhance bacterial clearance from the blood of mice pretreated or not enhance bacterial clearance from the blood of mice pretreated or not pretreated with CY, FOM(+) significantly suppressed tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 levels in the serum of mice after gut-derived sepsis. These results indicate that both FOM and FOM(+) have protective effects against P. aeruginosa bacteremia, despite a lack of specific activity of FOM(+), and suggest that FOM may possess immunomodulating activity and that it induces a protective effect. The protective mechanism is speculated to be that FOM modulates the vivo production of inflammatory cytokines.

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