scholarly journals Orexitropic Signaling Proteins in Obese Children

2007 ◽  
Vol 7 ◽  
pp. 1263-1271 ◽  
Author(s):  
Ljiljana Saranac ◽  
Bojko Bjelakovic ◽  
Hristina Stamenkovic ◽  
Borislav Kamenov
Keyword(s):  
Body Mass ◽  
Central Obesity ◽  
Energy Homeostasis ◽  
Leptin Resistance ◽  
Signaling Proteins ◽  
Obese Children ◽  
Significant Difference ◽  
The Mean ◽  
Very High

Adipose tissue is not only the main organ for energy storage, but it also has endocrine properties, producing “adipokines” responsible for energy homeostasis, insulin sensitivity, and inflammation. Leptin, produced by adipocytes, is the key hormone in appetite regulation and suppression of orexigenic, hypothalamic neuropeptide Y (NPY). We wanted to establish and compare levels of leptin and NPY in different obesity types in childhood, and to investigate their correlations with auxological parameters. Twenty-one obese children (seven girls and 14 boys), divided into two groups, were compared with 14 controls. The mean age of the study group was 10.81 ± 3.69 years and the mean puberty stage was 2.21. The mean body mass index (BMI) was 32.80 kg/m2(range 23.30– 47.02) and the mean overweight 30.73 kg (range 8.00–74.00). The mean leptin level was higher in boys and in the group with central obesity, but was not significant. Leptin/NPY ratio and leptin/BMI ratio was also higher in the central obesity group and there was a more significant difference compared with controls. We found significant correlation of the leptin level with body mass (BM), body mass excess (BME), and BMI (p < 0.05). The mean leptin level in obese children was very high (36.39 ng/ml). Leptin and NPY levels showed inverse values in two different obesity types. Results are suggestive for leptin resistance rather than leptin deficiency in our group of obese children. Orexitropic signaling proteins correlated significantly with auxological parameters. Determination of the leptin and NPY concentrations provided evidence that obesity represents disease with neuroendocrine dysfunction and high leptin/NPY ratio, which could be a useful marker for central obesity.

scholarly journals Kejadian mikropenis pada anak obes

2009 ◽  
Vol 6 (1) ◽  
pp. 8
Author(s):  
Siswanto Basuki ◽  
Madarina Julia ◽  
Soeroyo Machfudz
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Skinfold Thickness ◽  
Symphysis Pubis ◽  
Obese Children ◽  
Cross Sectional ◽  
Age Related ◽  
Significant Difference ◽  
Penis Length ◽  
The Mean

Background : Obese children are more likely to have less testosterone, which may lead to disorder of penile development.Objectives : To assess the association between obesity in children and the occurrence of micropenis. Methods : TA cross sectional study was carried out in 36 obese and 28 non- obese pubertal male children (10-13 years old) and 49 obese and 36 non-obese prepubertal male children (4-7 years old). Obesity was defined as body mass index (BMI) equivalent to or above the 95th percentile of the CDC 2000 growth reference standard. Length of the penis was measured perpendicular to the surface of the os symphysis pubis to the tip of the glans penis. Skinfold thickness was measured on the area of mons pubis using a caliper. Volume of the testis was measured using an orchidometer. Results : The mean (SD) of penis length in 36 pubertal obese and 28 non-obese children were 5.56 (1.14) cm and 6.05 (1.37) cm, respectively; whereas the mean (SD) of penis length in 49 pre-pubertal obese and 39 non-obese children were 5.09 (0.76) cm and 5.36 (0.56) cm, respectively. There was significant difference in the mean (95% CI) length of penis in pubertal obese and non-obese children (p = 0.04). Fisher's exact test showed that the occurrence of micropenis was not associated with obesity, age, fat thickness on mons pubis, and volume of the testicles.Conclusion : There was no significant difference in the occurrence of micropenis, but there was significant difference in the mean length of penis in obese children and children with normal age-related body mass index. 

Detection of Circulating Tissue Factor and Factor VII in a Normal Population

1996 ◽  
Vol 75 (05) ◽  
pp. 772-777 ◽  
Author(s):  
Sybille Albrecht ◽  
Matthias Kotzsch ◽  
Gabriele Siegert ◽  
Thomas Luther ◽  
Heinz Großmann ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Normal Population ◽  
Mean Value ◽  
Factor Vii ◽  
Significant Difference ◽  
Age Dependent ◽  
The Mean ◽  
Highly Correlated ◽  
And Gender

SummaryThe plasma tissue factor (TF) concentration was correlated to factor VII concentration (FVIIag) and factor VII activity (FVIIc) in 498 healthy volunteers ranging in age from 17 to 64 years. Immunoassays using monoclonal antibodies (mAbs) were developed for the determination of TF and FVIIag in plasma. The mAbs and the test systems were characterized. The mean value of the TF concentration was 172 ± 135 pg/ml. TF showed no age- and gender-related differences. For the total population, FVIIc, determined by a clotting test, was 110 ± 15% and the factor VIlag was 0.77 ± 0.19 μg/ml. FVII activity was significantly increased with age, whereas the concentration demonstrated no correlation to age in this population. FVII concentration is highly correlated with the activity as measured by clotting assay using rabbit thromboplastin. The ratio between FVIIc and FVIIag was not age-dependent, but demonstrated a significant difference between men and women. Between TF and FVII we could not detect a correlation.

scholarly journals First evaluation of coral recruitment in Madagascar

2021 ◽  
Vol 20 (1) ◽  
pp. 47-62
Author(s):  
Gildas G.B. Todinanahary ◽  
Nomeniarivelo Hasintantely ◽  
Igor Eeckhaut ◽  
Thierry Lavitra
Keyword(s):  
Larval Density ◽  
Average Density ◽  
Recruitment Rate ◽  
Seasonal Distribution ◽  
Coral Recruitment ◽  
Significant Difference ◽  
Southwest Region ◽  
The Mean ◽  
First Time ◽  
Very High

The distribution of larvae and recruitment of scleractinians in the southwest region of Madagascar were evaluated for the first time between October 2013 and September 2014 at 3 sites. The presence of coral larvae (planulae) was monitored through weekly sampling using a plankton net and the recruitment rate evaluated by monthly sampling of the newly settled corals (<1 year stage) on recruitment tiles and by a monitoring of the recruitment of juveniles (1< Juveniles < 2 years) using the quadrat method. Planulae were present in the plankton for 9 months during the survey. The recorded mean annual density of planula varied from 0.43 ± 0.41 larvae m-3 to 3.23 ± 5.72 larvae m-3 depending on site, with a peak in larval density towards the end of November and the beginning of December. The variability in the occurrence of planula is very high and implied that the density observed in the year does not present a significant difference between the sites (pKW=0.33). The average density of total recruits was 620.13 ± 621.30 recruits m-2, 40.28 ± 50.97 recruits m-2 and 36.34 ± 33.82 recruits m-2, respectively at the sites of Nosy Tafara, Grande Vasque and Rose Garden. Seasonal distribution of coral recruitment was different between the sites. The mean annual density of newly settled recruits (< 1 month stage) was significantly higher at Nosy Tafara with 94.91±101.08 recruits m-2 compared to Grande Vasque and Rose Garden with 18.75±34.32 recruits m-2 and 11.57±18.47 recruits m-2 (pKW<0.001), respectively. The highest density of newly settled recruits was observed between October to December. Higher density of recruits was also observed in March at Nosy Tafara and in May at all three sites. Results of juvenile monitoring showed high rates (> 10 juveniles m-2) compared to other regions and the threshold, but it revealed high mortality among recruits. Coral recruitment in the southwest region of Madagascar was found to be high and could result in increased resilience of the coral reef assemblages.

scholarly journals Assessment of the Non-Cystic Fibrosis Bronchiectasis Severity: The FACED Score vs the Bronchiectasis Severity Index

2015 ◽  
Vol 9 (1) ◽  
pp. 46-51 ◽  
Author(s):  
J Minov ◽  
J Karadzinska-Bislimovska ◽  
K Vasilevska ◽  
S Stoleski ◽  
D Mijakoski
Keyword(s):  
Body Mass Index ◽  
Cystic Fibrosis ◽  
Clinical Practice ◽  
Observational Study ◽  
Body Mass ◽  
Severity Index ◽  
Sufficient Power ◽  
Chronic Colonization ◽  
The Mean

Introduction : Non-cystic fibrosis bronchiectasis (NCFB) is a multidimensional disease, and no single isolated parameter is proved to have sufficient power for any overall determination of its severity and prognosis. Objective : To compare the results of the assessment of the NCFB severity with respect to its prognosis in the same patients by two different validated scores, i.e. the FACED score and the Bronchiectasis Severity Index (BSI). Methods : An observational study including 37 patients with NCFB (16 males and 21 female aged 46 to 76 years) was performed. All patients underwent evaluation of the variables incorporated in the FACED score (FEV1 % predicted, age, chronic colonization by Pseudomaonas aeruginosa, radiological extent of the disease, and dyspnea) and in the BSI (age, body mass index, FEV1 % predicted, hospitalization and exacerbations in previous year, dyspnea, chronic colonization by Pseudomaonas aeruginosa and other microrganisms, and radiological extent of the disease). Results : According to the value of the derived overall FACED score we found 17 patients (45.9%) with mild bronchiectasis, 14 patients (37.8%) with moderate bronchiectasis and 6 patients (16.2%) with severe bronchiectasis. The mean derived FACED score was 3.4 ± 1.3. In addition, according to the value of the derived overall BSI score, the frequency of patients with low, intermediate and high BSI score was 16 patients (43,2%), 14 patients (37.8%) and 7 patients (18.9%), respectively. The mean derived BSI score was 6.4 ± 2.5. Conclusion : We found similar results by the assessment of the NCFB severity in regard to its prognosis by both the FACED score and the BSI. Further studies determining how these scores may impact clinical practice are needed.

scholarly journals Comparação entre a evolução de pré-escolares com fibrose cística identificados por triagem neonatal ou por sintomatologia clínica

2018 ◽  
Vol 28 (2) ◽  
pp. 29566
Author(s):  
Magali Santos Lumertz ◽  
Ângela De Moura ◽  
Leonardo Araújo Pinto ◽  
Paulo Augusto Moreira Camargos ◽  
Paulo José Cauduro Marostica
Keyword(s):  
Body Mass Index ◽  
Cystic Fibrosis ◽  
Pulmonary Function ◽  
Body Mass ◽  
Screening Test ◽  
Preschool Age ◽  
Index Number ◽  
Significant Difference ◽  
The Mean

AIMS: To compare clinical, laboratory and spirometric parameters of preschoolers (ages from three to six years old) with cystic fibrosis identified by abnormal newborn screening test (NS group), with data of patients whose diagnostic suspicion arose from characteristic clinical signs and symptoms (CS group).METHODS:  Retrospective cohort study, with a sample obtained from the medical charts of patients who received specialized and multidisciplinary outpatient follow-up. All the included children had a confirmed diagnosis of cystic fibrosis by sweat electrolyte testing and/or genetic sequencing. Variables included sex, weight, height, body mass index, number of hospitalizations per year, Pseudomonas aeruginosa colonization, presence of pancreatic insufficiency and Shwachman score, which covers four domains: general activity, nutrition, radiological examination and physical evaluation, each one scored between 5 and 25 points. A total score ≤40 points indicates severe state, and ≥86 points indicates excellent state. For comparison of pulmonary function, data from the last spirometry performed before the age of six years were used. Outcomes were compared by chi-square or Student's t test, with a significance limit of 0.05.RESULTS: Twenty-four patients were included in the study, seven children in the NS group and 17 children in the CS group. The children of the NS group started follow-up with a mean age of 1.51±2.04 months, and those of the CS group started with 3.77±1.80 months (p=0.014). The mean Shwachman score was 94.40±2.19 in the NS vs. 87.67±8.00 in the CS group (p=0.018). The mean Z score for body mass index was 0.95±1.02 in the NS group vs. 0.51±1.05 in the CS group (p=0.051). Spirometric variables had slightly higher values in the NS group, with no statistically significant difference between groups.CONCLUSIONS: The results suggest that those patients diagnosed with cystic fibrosis from the neonatal screening test suspicion benefited from an early intervention, being able to initiate pulmonary function tests and receive treatment and counseling earlier. Evaluation of clinical parameters with the Shwachman score showed that benefits could be already observed at the preschool age.

Colorimetric Method for Rapid Determination of Serum Arginase

1967 ◽  
Vol 13 (10) ◽  
pp. 900-908 ◽  
Author(s):  
Brigitta Mellerup
Keyword(s):  
Rapid Determination ◽  
Colorimetric Method ◽  
Normal Range ◽  
Clinical Routine ◽  
Mean Values ◽  
Enzymatic Formation ◽  
Significant Difference ◽  
The Mean ◽  
Normal Men

Abstract A method for the determination of serum arginase is given which combines the enzymatic formation of urea with the sensitive method of Coulombe (1) for measuring this substance. This procedure allows more accurate determinations in the normal range than do previous methods described and is convenient for clinical routine. Significant difference is found between the mean values of normal men and women, 3.9 units/L. for the former and 2.9 units/L. for the latter.

scholarly journals Zero order and area under curve spectrophotometric methods for determination of Levocetirizine in pharmaceutical formulation

2015 ◽  
Vol 1 (6) ◽  
pp. 270
Author(s):  
Audumbar Digambar Mali ◽  
Ritesh Bathe ◽  
Manojkumar Patil ◽  
Ashpak Tamboli
Keyword(s):  
Area Under The Curve ◽  
Zero Order ◽  
Pharmaceutical Dosage Forms ◽  
Mean Values ◽  
Spectrophotometric Methods ◽  
Ich Guidelines ◽  
Significant Difference ◽  
Curve Method ◽  
The Mean

Simple, fast and reliable spectrophotometric methods were developed for determination of Levocetirizine in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in methanol. The quantitative determination of the drug was carried out using the zero order derivative values measured at 230 nm and the area under the curve method values measured at 227-234 nm (n=2). Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Levocetirizine using 5-25?g/ml (r=0.998 and r=0.999) for zero order and area under the curve spectrophotometric method. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. Developed spectrophotometric methods in this study are simple, accurate, precise and sensitive to assay of Levocetirizine in tablets.

Prediction of the Maximum Number of Repetitions and Repetitions in Reserve From Barbell Velocity

2018 ◽  
Vol 13 (3) ◽  
pp. 353-359 ◽  
Author(s):  
Amador García-Ramos ◽  
Alejandro Torrejón ◽  
Belén Feriche ◽  
Antonio J. Morales-Artacho ◽  
Alejandro Pérez-Castilla ◽  
...  
Keyword(s):  
Body Mass ◽  
General Equation ◽  
Bench Press ◽  
Body Height ◽  
Strong Relationship ◽  
Training Set ◽  
Mean Velocity ◽  
The Mean ◽  
Acceptable Reliability

Purpose: To provide 2 general equations to estimate the maximum possible number of repetitions (XRM) from the mean velocity (MV) of the barbell and the MV associated with a given number of repetitions in reserve, as well as to determine the between-sessions reliability of the MV associated with each XRM. Methods: After determination of the bench-press 1-repetition maximum (1RM; 1.15 ± 0.21 kg/kg body mass), 21 men (age 23.0 ± 2.7 y, body mass 72.7 ± 8.3 kg, body height 1.77 ± 0.07 m) completed 4 sets of as many repetitions as possible against relative loads of 60%1RM, 70%1RM, 80%1RM, and 90%1RM over 2 separate sessions. The different loads were tested in a randomized order with 10 min of rest between them. All repetitions were performed at the maximum intended velocity. Results: Both the general equation to predict the XRM from the fastest MV of the set (CV = 15.8–18.5%) and the general equation to predict MV associated with a given number of repetitions in reserve (CV = 14.6–28.8%) failed to provide data with acceptable between-subjects variability. However, a strong relationship (median r2 = .984) and acceptable reliability (CV < 10% and ICC > .85) were observed between the fastest MV of the set and the XRM when considering individual data. Conclusions: These results indicate that generalized group equations are not acceptable methods for estimating the XRM–MV relationship or the number of repetitions in reserve. When attempting to estimate the XRM–MV relationship, one must use individualized relationships to objectively estimate the exact number of repetitions that can be performed in a training set.

scholarly journals An experiment with the balance to find if change of temperature has any effect upon weight

1905 ◽  
Vol 76 (512) ◽  
pp. 445-457 ◽  
Keyword(s):  
Low Temperatures ◽  
Secondary Effect ◽  
Boiling Liquid ◽  
The Earth ◽  
Exact Determination ◽  
The Mean ◽  
Very High ◽  
The Ideal

In all the experiments hitherto made to determine the gravitative attraction between two masses, the temperature has not varied more than a few degrees, and there are no results which would enable us to detect with certainty any dependence of attraction upon temperature even if such dependence exists. It is true, as Professor Hicks has pointed out, that Baily’s results for the Mean Density of the Earth, if arranged in the order of the temperature of the apparatus when they were obtained, show a fall in value as the temperature rises. But this is almost certainly some secondary effect, due to errors in the measurements of the apparatus, or to the seasons at which different attracted masses were used. The ideal experiment to find if temperature has an effect on gravitation would consist in one determination of the gravitative attraction between two masses at, say 15°C., and another determination at, say, the temperature of boiling liquid air. But the difficulties of exact determination at ordinary temperatures are not yet overcome, and at any very high or very low temperatures, they would be so much increased that the research seems at present hopeless.

Carbon tetrachloride poisoning in sheep: Effect upon the serum E260 value and plasma volume

1962 ◽  
Vol 13 (6) ◽  
pp. 1073 ◽  
Author(s):  
CH Gallagher
Keyword(s):  
Carbon Tetrachloride ◽  
No Value ◽  
Plasma Volume ◽  
Stomach Tube ◽  
Ccl4 Poisoning ◽  
The Mean ◽  
The One ◽  
Diagnostic Criterion ◽  
Very High

Serum E260 values were determined at intervals in sheep which were given 50 ml carbon tetrachloride (CCl4) by stomach tube into the rumen, and in untreated sheep. After administration of the drug, the mean E260 value fell initially, being minimal at 3 hr. At this time, the circulating plasma volume had increased by one-fifth, and it is considered that this dilution factor largely explained the fall. The group mean for non-fatal cases rose above the pre-administration level at 7 hr, then returned to it by 24 hr. However, in the one sheep that died from CCl4 poisoning, the serum E260 value remained very high until death at 46 hr. In view of the significant variations in serum E260 values between untreated sheep, and the significant random variations in serum E260 values between times of bleeding such sheep, it is concluded that the determination of serum E260 values at isolated times in individual sheep is of no value as a diagnostic criterion of CCl4 poisoning.

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