scholarly journals Body fat volumes and distribution in chronic schizophrenia compared to healthy controls; a cross-sectional MR study

Author(s):  
Emanuele Felice Osimo ◽  
Stefan P Brugger ◽  
Emma Louise Thomas ◽  
Oliver D Howes

People with schizophrenia show higher risk for abdominal obesity than the general population, which could contribute to excess mortality. However, it is unclear whether this is driven by alterations in abdominal fat partitioning. Here, we test the hypothesis that individuals with schizophrenia show a higher proportion of visceral to total body fat measured using MRI. We recruited 38 patients with schizophrenia and 38 healthy controls matched on age, sex, ethnicity and body mass index. We found no significant difference in body fat distribution between groups, suggesting that increased abdominal obesity in schizophrenia is not associated with altered fat distribution.

2020 ◽  
Vol 9 ◽  
Author(s):  
Haleama Al Sabbah

Abstract The present study assessed the associations of overweight, obesity and anaemia with selected lifestyle factors, total body fat and abdominal obesity among female university students in Dubai. A total of 251 female students from a national university in Dubai participated in the present study. Weight, height, waist circumference, Hb level and total body fat percentage were measured. Participants also completed a self-reported questionnaire that included items related to the factors of obesity, anaemia and lifestyle. The study was approved by the University Ethical Committee. Almost one-third of the participants were overweight/obese; 8⋅5 % had abdominal obesity while 18⋅1 % had anaemia. Out of the total, 71⋅7 % reported that they have irregular meals and the highest percentages were found among obese (89⋅3 %) and overweight (78⋅0 %) compared with normal-weight (65⋅4 %) students (P < 0⋅05). Overweight/obese students reported that they exercise more than those of normal weight (P = 0⋅05). Students with anaemia reported less exercise than students without anaemia (P = 0⋅05). Also, the percentage of total body fat was found to be the highest (38⋅9 %) among students with anaemia (P < 0⋅05). Overweight, obesity and anaemia are prevalent among female university students. Anaemia seems to be associated with the percentage of total body fat, lack of physical activity and junk food. Further studies are required to investigate the detailed dietary habits of overweight and obese young adult females with anaemia.


Author(s):  
Magnus Dencker ◽  
Anton Danielson ◽  
Magnus K. Karlsson ◽  
Per Wollmer ◽  
Lars B. Andersen ◽  
...  

AbstractBackground:The aim of the study was to assess possible relationships between adipocyte fatty acid-binding protein (FABP4) and total body fat (TBF), abdominal fat, body fat distribution, aerobic fitness, blood pressure, cardiac dimensions and the increase in body fat over 2 years in a community sample of children.Methods:A cross-sectional study was used in a community sample of 170 (92 boys and 78 girls) children aged 8–11 years. TBF and abdominal fat (AFM) were measured by dual-energy X-ray absorptiometry (DXA). TBF was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VOResults:Partial correlations, with adjustment for sex, between FABP4 vs. ln TBF, ln BF%, ln AFM, AFM/TBF and VOConclusions:Findings from this community-based cohort of young children show that increased body fat and abdominal fat, more abdominal body fat distribution, low fitness, more LVM and increased LA, increased SBP and PP were all associated with increased levels of FABP4. Increase in TBF and abdominal fat over 2 years were also associated with increased levels of FABP4.


2002 ◽  
Vol 45 (6) ◽  
pp. 535-545
Author(s):  
A. D. Mitchell ◽  
A. Scholz ◽  
V. Pursel

Abstract. The purpose of this study was to evaluate the use of a cross-sectional scan as an alternative to the total body DXA scan for predicting the body composition of pigs in vivo. A total of 212 pigs (56 to 138 kg live body weight) were scanned by DXA. The DXA scans were analyzed for percentage fat and lean in the total body and in 14 cross-sections (57.6 mm wide): 5 in the front leg/thoracic region, 4 in the abdominal region, and 5 in the back leg region. Regression analysis was used to compare total body and cross-sectional DXA results and chemical analysis of total body fat, protein and water. The relation (R2) between the percentage fat in individual slices and the percentage of total body fat measured by DXA ranged from 0.78 to 0.97 and by chemical analysis from 0.71 to 0.85, respectively. The relation between the percentage of lean in the individual slices and chemical analysis for percentage of total body protein and water ranged from 0.48 to 0.60 and 0.56 to 0.76, respectively. These results indicate that total body composition of the pig can be predicted (accurately) by performing a time-saving single-pass cross-sectional scan.


2017 ◽  
Vol 36 (5) ◽  
pp. 1411-1419 ◽  
Author(s):  
Taulant Muka ◽  
Lauren C. Blekkenhorst ◽  
Joshua R. Lewis ◽  
Richar L. Prince ◽  
Nicole S. Erler ◽  
...  

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S435-S435
Author(s):  
M Bletsa ◽  
A Karachaliou ◽  
G Kokkotis ◽  
M M Tsoutska ◽  
S Andoniadi ◽  
...  

Abstract Background Inflammatory bowel disease (IBD) has been traditionally associated with malnutrition and increased prevalence of underweight status. Nevertheless, according to recent reports, there appears to be an increase in the percentage of overweight individuals among patients with Crohn’s disease (CD) or ulcerative colitis (UC). In the present study, we aimed to evaluate the body composition of a cohort of Greek patients with IBD. Methods We analysed data from 88 patients with IBD (CD:58, UC:30, female: 45). Body mass index (BMI) was calculated and waist circumference (WC) was measured in all participants. Body composition was evaluated with a multi-frequency bioelectrical impedance segmental body composition analyser (BIA) (Tanita MC-780) and with dual-energy X-ray absorptiometry (DXA). Results 9.1% (n = 8) of patients had low BMI (&lt;18.5), 53.4% (n = 47) normal, 22.7% (n = 20) were overweight and 14.8% (n = 13) obese. No differences were seen between CD vs. UC. Furthermore, 27.3% (n = 24) of women had WC &lt; 80 cm and 27.3% (n = 24) of men had &lt; 94 cm. Referring to % total body fat, as reported by BIA, 46.5% (n = 20) of men and 11.1% (n = 5) of women had total body fat &lt;20%, 46.5% (n = 20) of men and 44.4% (n = 20) of women had 21–30%, 7% (n = 3) of men and 28.9% (n = 13)of women 31–40% and 15.6% (n = 7)of women &gt;41%. According to DXA measurements, 25.6% (n = 11) of men had total body fat &lt;20%, 46.5% (n = 20) of men and 15.6% (n = 7) of women had 21–30%, 25.6% (n = 11) of men and 46.7% (n = 21) of women 31–40% and 2.3% (n = 1) of men and 37.8% (n = 17) of women &gt;41%. There was no significant difference in % total body fat between CD and UC patients in either measurement. We observed a significant difference between the two methods regarding the estimation of % body fat, as BIA measurements were lower than those obtained with DXA (p &lt; 0.001, median = 5.53%, 95% confidence interval = 4.82–6.24%). Nevertheless there was a significant correlation between BIA and DXA measurements in the same individual (r2 = 0.9025, p &lt; 0.001). Conclusion We found a large proportion of overweight/obese patients in our IBD cohort. The association with increased WC may imply that the total abdominal fat is increased in such patients. As excessive fat content has been shown to negatively affect IBD patients in multiple ways, our results emphasise the need for better assessment of body composition and dietetic interventions in this population.


2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
J Henzel ◽  
M Makarewicz-Wujec ◽  
L Wardziak ◽  
P Trochimiuk ◽  
C Kepka ◽  
...  

Abstract Introduction Contradictory reports are available on the role of adipose tissue in the pathophysiology and progression of coronary artery disease (CAD). It seems accepted that local fat distribution is more relevant than the general amount of body fat. As in the case of visceral fat, pericardial adipose tissue (PEAT) has been postulated an important mediator of metabolic risk, with a special role attributed to epicardial adipose tissue (EAT). Purpose To study the effect of intensive dietary and lifestyle modification on the distribution of body fat in patients diagnosed with stable CAD qualified to conservative treatment. Methods Total body fat mass (TBF), visceral fat area (VFA), PEAT volume, and EAT volume were measured in 67 participants (43% women) of the DISCO-CT trial (Dietary Intervention to Stop COronary Atherosclerosis in Computed Tomography, NCT02571803) who completed the study by the end of 2018. All patients, randomly assigned to either experimental or control arm in a 1:1 fashion, were regularly followed-up at our site, with those in the experimental arm being strictly supervised by a dietitian to stick to Dietary Approaches to Stop Hypertension (DASH) diet and encouraged to lifestyle changes atop optimal medical therapy. Contrast-enhanced coronary computed tomography was performed at baseline and after the median time of 59 weeks (2x192-multislice scanner, temporal resolution 66 ms, Somatom Force, Siemens). PEAT and EAT volumes, expressed in mm3, were measured with a dedicated offline workstation (syngo.via Frontier, Siemens Healthcare) using a semiautomatic segmentation technique (window width range −195 to −45 Hounsfield units). TBF, expressed in kg, and VFA, expressed in cm2, were measured using the InBody S10 Body Water Analyser at baseline and completion of the study. 57% of subjects included into the analysis represented the experimental arm. Results There were no significant between-arm differences in baseline TBF, VFA, PEAT, and EAT volumes. A significant reduction by 3.7±5.0 kg in TBF (p<0.001; 95% CI 2.1, 5.3) and by 19.7±30.1 cm2 in VFA (p<0.001; 95% CI 9.8, 29.6) was observed in the experimental arm, while in the control group both TBF and VFA irrelevantly increased, by 0.6±4.7 kg (p=0.53; 95% CI −2.4, 1.3) and 2.2±27.0 cm2 (p=0.67; 95% CI −12.7, 8.2), respectively. A significant decrease in PEAT volume, by 19.9±43.0 mm3 (p=0.007; 95% CI 5.8, 34.1), was observed in the experimental group, compared to a non-significant PEAT volume reduction by 5.8±3.5.0 mm3 (p=0.38, 95% CI −7.5; 19.2) in the control group. Contrarily, no significant changes in EAT volumes were observed in either experimental (reduction by 3.8±15.2 mm3; p=0.13, 95% CI −1.2, 8.8) or control arm (reduction by 5.1±17.2 mm3; p=0.13, 95% CI −1.5, 11.6). Conclusion Intensive dietary intervention in patients with stable CAD can lead to a significant reduction in total body fat, visceral fat and pericardial fat, this effect, however, may not apply to epicardial fat. Acknowledgement/Funding This study was founded by a grant (2.15/III/15) from the Institute of Cardiology in Warsaw, Poland


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