scholarly journals The Long and the Short of Serotonergic Stimulation: Optogenetic activation of dorsal raphe serotonergic neurons changes the learning rate for rewards

2017 ◽  
Author(s):  
Kiyohito Iigaya ◽  
Madalena S. Fonseca ◽  
Masayoshi Murakami ◽  
Zachary F. Mainen ◽  
Peter Dayan
Keyword(s):  
Dorsal Raphe ◽  
Optogenetic Stimulation ◽  
Learning Rates ◽  
Serotonin Neurons ◽  
History Of ◽  
Learning And Cognition ◽  
Foraging Task ◽  
The Impact ◽  
Dorsal Raphé ◽  
Stimulation Of

AbstractSerotonin plays an influential, but computationally obscure, modulatory role in many aspects of normal and dysfunctional learning and cognition. Here, we studied the impact of optogenetic stimulation of dorsal raphe serotonin neurons in mice performing a non-stationary, reward-driven, foraging task. We report that activation of serotonin neurons significantly boosted learning rates for choices following long inter-trial-intervals that were driven by the recent history of reinforcement.

scholarly journals Slow motion

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Naoshige Uchida ◽  
Jeremiah Y Cohen
Keyword(s):  
Slow Motion ◽  
Dorsal Raphe ◽  
Motor Deficits ◽  
Optogenetic Stimulation ◽  
Serotonin Neurons ◽  
Dorsal Raphé ◽  
Stimulation Of

Optogenetic stimulation of serotonin neurons in the dorsal raphe causes mice to move more slowly without causing any apparent motor deficits or anxiety-like effects.

scholarly journals Intense threat switches dorsal raphe serotonin neurons to a paradoxical operational mode

Science ◽  
2019 ◽  
Vol 363 (6426) ◽  
pp. 538-542 ◽  
Author(s):  
Changwoo Seo ◽  
Akash Guru ◽  
Michelle Jin ◽  
Brendan Ito ◽  
Brianna J. Sleezer ◽  
...  
Keyword(s):  
Escape Behavior ◽  
Dorsal Raphe ◽  
Neural Dynamics ◽  
Operational Mode ◽  
Serotonin Neurons ◽  
Operational Modes ◽  
High Threat ◽  
Selection Of ◽  
Dorsal Raphé ◽  
Stimulation Of

Survival depends on the selection of behaviors adaptive for the current environment. For example, a mouse should run from a rapidly looming hawk but should freeze if the hawk is coasting across the sky. Although serotonin has been implicated in adaptive behavior, environmental regulation of its functional role remains poorly understood. In mice, we found that stimulation of dorsal raphe serotonin neurons suppressed movement in low- and moderate-threat environments but induced escape behavior in high-threat environments, and that movement-related dorsal raphe serotonin neural dynamics inverted in high-threat environments. Stimulation of dorsal raphe γ-aminobutyric acid (GABA) neurons promoted movement in negative but not positive environments, and movement-related GABA neural dynamics inverted between positive and negative environments. Thus, dorsal raphe circuits switch between distinct operational modes to promote environment-specific adaptive behaviors.

Stimulation of the rat dorsal raphe in vivo releases labeled serotonin from the parietal cortex

1981 ◽  
Vol 216 (2) ◽  
pp. 351-360 ◽  
Author(s):  
Hiroshi Fujiwara ◽  
Masaharu Uemoto ◽  
Chikako Tanaka
Keyword(s):  
Parietal Cortex ◽  
Dorsal Raphe ◽  
Dorsal Raphé ◽  
Stimulation Of

scholarly journals Anatomical, Physiological, and Functional Heterogeneity of the Dorsal Raphe Serotonin System

2018 ◽  
Author(s):  
Jing Ren ◽  
Drew Friedmann ◽  
Jing Xiong ◽  
Cindy D. Liu ◽  
Katherine E. DeLoach ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Glutamate Transporter ◽  
Dorsal Raphe ◽  
Loss Of Function ◽  
Homogeneous Population ◽  
Functional Studies ◽  
Serotonin System ◽  
Distinct Cell ◽  
Serotonin Neurons ◽  
Dorsal Raphé

SummaryThe dorsal raphe (DR) constitutes a major serotonergic input to the forebrain, and modulates diverse functions and brain states including mood, anxiety, and sensory and motor functions. Most functional studies to date have treated DR serotonin neurons as a single, homogeneous population. Using viral-genetic methods, we found that subcortical-vs. cortical-projecting serotonin neurons have distinct cell body distributions within the DR and different degrees of coexpressing a vesicular glutamate transporter. Further, the amygdala-and frontal cortex-projecting DR serotonin neurons have largely complementary whole-brain collateralization patterns, receive biased inputs from presynaptic partners, and exhibit opposite responses to aversive stimuli. Gain-and loss-of-function experiments suggest that amygdala-projecting DR serotonin neurons promote anxiety-like behavior, whereas frontal cortex-projecting neurons promote active coping in face of challenge. These results provide compelling evidence that the DR serotonin system contains parallel sub-systems that differ in input and output connectivity, physiological response properties, and behavioral functions.

scholarly journals Enhanced 5-HT1A receptor-dependent feedback control over dorsal raphe serotonin neurons in the SERT knockout mouse

2015 ◽  
Vol 89 ◽  
pp. 185-192 ◽  
Author(s):  
Mariano Soiza-Reilly ◽  
Nathalie M. Goodfellow ◽  
Evelyn K. Lambe ◽  
Kathryn G. Commons
Keyword(s):  
Feedback Control ◽  
Knockout Mouse ◽  
Dorsal Raphe ◽  
Serotonin Neurons ◽  
Dorsal Raphé
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