scholarly journals The role of dendritic action potentials and Ca2+ influx in the induction of homosynaptic long-term depression in hippocampal CA1 pyramidal neurons.

1996 ◽  
Vol 3 (2-3) ◽  
pp. 160-169 ◽  
Author(s):  
B R Christie ◽  
J C Magee ◽  
D Johnston
Keyword(s):  
Action Potentials ◽  
Pyramidal Neurons ◽  
Long Term Depression ◽  
Ca1 Pyramidal Neurons ◽  
Hippocampal Ca1

Serotonin Modulates Spike Backpropagation and Associated [Ca2+]i Changes in the Apical Dendrites of Hippocampal CA1 Pyramidal Neurons

1999 ◽  
Vol 81 (1) ◽  
pp. 216-224 ◽  
Author(s):  
Vladislav M. Sandler ◽  
William N. Ross
Keyword(s):  
Action Potentials ◽  
Pyramidal Neurons ◽  
Peak Potential ◽  
Fura 2 ◽  
Ca1 Pyramidal Neurons ◽  
Ca1 Region ◽  
Artificial Cerebrospinal Fluid ◽  
Hippocampal Ca1 ◽  
Conductance Increase ◽  
Apical Dendrites

Sandler, Vladislav M. and William N. Ross. Serotonin modulates spike backpropagation and associated [Ca2+]i changes in the apical dendrites of hippocampal CA1 pyramidal neurons. J. Neurophysiol. 81: 216–224, 1999. The effect of serotonin (5-HT) on somatic and dendritic properties was analyzed in pyramidal neurons from the CA1 region in slices from the rat hippocampus. Bath-applied 5-HT (10 μM) hyperpolarized the soma and apical dendrites and caused a conductance increase at both locations. In the dendrites (200–300 μm from the soma) trains of antidromically activated, backpropagating action potentials had lower peak potentials in 5-HT than in normal artificial cerebrospinal fluid. Spike amplitudes were about the same in the two solutions. Similar results were found when the action potentials were evoked synaptically with stimulation in the stratum oriens. In the soma, spike amplitudes increased in 5-HT, with only a small decrease in the peak potential. Calcium concentration measurements, made with bis-fura-2 injected through patch electrodes, showed that the amplitude of the [Ca2+]i changes was reduced at all locations in 5-HT. The reduction of the [Ca2+]i change in the soma was confirmed in slices where cells were loaded with fura-2-AM. The reduction at the soma in 5-HT, where the spike amplitude increased, suggests that the reduction is due primarily to direct modulation of Ca2+ channels. In the dendrites, the reduction is due to a combination of this channel modulation and the lowering of the peak potential of the action potentials.

High Ca2+/low Mg2+ solution induces long-term depression in rat CA1 pyramidal neurons

2000 ◽  
Vol 283 (2) ◽  
pp. 141-144 ◽  
Author(s):  
Sheng-Tian Li ◽  
Kunio Kato ◽  
Katsuhiko Mikoshiba
Keyword(s):  
Pyramidal Neurons ◽  
Long Term Depression ◽  
Ca1 Pyramidal Neurons

scholarly journals Role of Glycine Receptors in Glycine-Induced LTD in Hippocampal CA1 Pyramidal Neurons

2011 ◽  
Vol 36 (9) ◽  
pp. 1948-1958 ◽  
Author(s):  
Rong-Qing Chen ◽  
Shan-Hui Wang ◽  
Wen Yao ◽  
Jing-Jing Wang ◽  
Fang Ji ◽  
...  
Keyword(s):  
Pyramidal Neurons ◽  
Glycine Receptors ◽  
Ca1 Pyramidal Neurons ◽  
Hippocampal Ca1

scholarly journals Inositol 1,4,5-Trisphosphate (IP3)-Mediated Ca2+Release Evoked by Metabotropic Agonists and Backpropagating Action Potentials in Hippocampal CA1 Pyramidal Neurons

2000 ◽  
Vol 20 (22) ◽  
pp. 8365-8376 ◽  
Author(s):  
Takeshi Nakamura ◽  
Kyoko Nakamura ◽  
Nechama Lasser-Ross ◽  
Jean-Gaël Barbara ◽  
Vladislav M. Sandler ◽  
...  
Keyword(s):  
Action Potentials ◽  
Pyramidal Neurons ◽  
Ca1 Pyramidal Neurons ◽  
Hippocampal Ca1 ◽  
Inositol 1,4,5 Trisphosphate
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