scholarly journals Drought-Induced Changes in the Redox State of α-Tocopherol, Ascorbate, and the Diterpene Carnosic Acid in Chloroplasts of Labiatae Species Differing in Carnosic Acid Contents

2003 ◽  
Vol 131 (4) ◽  
pp. 1816-1825 ◽  
Author(s):  
Sergi Munné-Bosch ◽  
Leonor Alegre
Keyword(s):  
Redox State ◽  
Carnosic Acid ◽  
Induced Changes

Mapping of capillary flow, cellular redox state, and resting membrane potential in hypoperfused rat myocardium

1999 ◽  
Vol 277 (5) ◽  
pp. H2050-H2064 ◽  
Author(s):  
Frank Brasch ◽  
Marion Neckel ◽  
Rolf Volkmann ◽  
Gerhard Schmidt ◽  
Gerhard Hellige ◽  
...  
Keyword(s):  
Membrane Potential ◽  
Trypan Blue ◽  
Redox State ◽  
Capillary Flow ◽  
Resting Membrane Potential ◽  
Capillary Perfusion ◽  
Cellular Redox ◽  
Nadh Fluorescence ◽  
Induced Changes ◽  
Tetramethylrhodamine Methyl Ester

The influence on myocyte viability of ischemia-induced changes in capillary perfusion was studied in the hearts of anesthetized rats subjected to partial occlusion of the left coronary artery for 45 min. Timed plasma labeling was applied to determine perfusion patterns. Changes in the fluorescence of preloaded potential-sensitive dyes [tetramethylrhodamine methyl ester (TMRM) and bis-oxonol], of trypan blue, and of endogeneous NADH were utilized in characterizing myocyte viability in histological sections of the heart. Within the hypoperfused zone, localized areas appeared vascularly nonlabeled for periods of at least 10 min. Within these areas a reduction in TMRM fluorescence occurred in 82.5% of the tissue, signaling a reduced resting membrane potential. In the same areas 37.7% of the myocytes revealed an NADH fluorescence lower than that regularly found in anoxic tissues. This correlated with an especially low level of TMRM, with increased fluorescence bis-oxonol and with an accumulation of trypan blue. In conclusion, in localized hypoperfusion-induced zones lacking capillary flow, an inhomogeneous pattern of reductions in myocyte viability develops, which appears to be relevant in ischemia-induced arrhythmias.

Morphological, physiological and metabolic comparisons between runner-like and sheet-like inbred lines of a colonial hydroid.

1998 ◽  
Vol 201 (20) ◽  
pp. 2821-2831 ◽  
Author(s):  
NW Blackstone
Keyword(s):  
Inbred Line ◽  
Redox State ◽  
Inbred Lines ◽  
Colony Morphology ◽  
Colony Development ◽  
Metabolic Capacity ◽  
Stolon Development ◽  
Morphological Differences ◽  
Induced Changes ◽  
Colonial Hydroid

Hydractiniid hydroids display a range of morphological variation from sheet-like forms (i.e. closely spaced polyps with high rates of stolon branching) to runner-like forms (i.e. widely spaced polyps with low rates of stolon branching), thus exemplifying the patterns of heterochrony found in many colonial animals. A sheet-like and a runner-like inbred line of Podocoryne carnea were produced to investigate this heterochronic variation further. Selection on colony morphology at the time of the initiation of medusa production resulted in dramatic differences by the F5 and F6 generations. Compared with colonies of the sheet-like inbred line, runner-like colonies exhibited smaller sizes at the initiation of medusa production, more irregular colony shapes and diminished stolon development relative to polyp development. In addition to these differences in colony morphology, runner-like colonies also exhibited larger medusae and a greater amount of gastrovascular flow to the peripheral stolons. To assess differences in the metabolic capacity underlying this variaton in flow, the redox state of the polyp epitheliomuscular cells was measured using the fluorescence of NAD(P)H. In response to feeding-induced changes in gastrovascular flow, runner-like colonies show greater redox variation than sheet-like ones, plausibly corresponding to the greater amounts of flow generated by the former colonies relative to the latter. Perturbing the system with dilute solutions of 2,4-dinitrophenol similarly indicates that runner-like colonies contain more functionally oxidizable NAD(P)H. The correlation between gastrovascular flow and morphological differences supports the hypothesis that the former mediates the timing of colony development, perhaps in concert with the observed variation in the redox state of polyp epitheliomuscular cells.

scholarly journals Assessment of Metformin-Induced Changes in Cardiac and Hepatic Redox State Using Hyperpolarized[1-13C]Pyruvate

Diabetes ◽  
2016 ◽  
Vol 65 (12) ◽  
pp. 3544-3551 ◽  
Author(s):  
Andrew J.M. Lewis ◽  
Jack J.J. Miller ◽  
Chloe McCallum ◽  
Oliver J. Rider ◽  
Stefan Neubauer ◽  
...  
Keyword(s):  
Redox State ◽  
Hepatic Redox State ◽  
Induced Changes

scholarly journals Assessment of Metformin induced changes in cardiac redox state using hyperpolarized[1-13C]pyruvate

2016 ◽  
Vol 18 (Suppl 1) ◽  
pp. O24
Author(s):  
Andrew Lewis ◽  
Chloe McCallum ◽  
Jack J Miller ◽  
Oliver Rider ◽  
Stefan Neubauer ◽  
...  
Keyword(s):  
Redox State ◽  
Induced Changes
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