scholarly journals Recurring main-chain anion-binding motifs in short polypeptides: nests

2004 ◽  
Vol 60 (11) ◽  
pp. 1935-1942 ◽  
Author(s):  
E. James Milner-White ◽  
J. Willem M. Nissink ◽  
Frank H. Allen ◽  
William J. Duddy
Keyword(s):  
Main Chain ◽  
Anion Binding ◽  
Binding Motifs ◽  
Chain Anion

Anion Binding Motifs:  Topicity and Charge in Amidocryptands

2005 ◽  
Vol 127 (39) ◽  
pp. 13478-13479 ◽  
Author(s):  
Sung Ok Kang ◽  
Douglas Powell ◽  
Kristin Bowman-James
Keyword(s):  
Anion Binding ◽  
Binding Motifs

[14]Heterophane prototypes containing azolium and/or azole anion-binding motifs

2013 ◽  
Vol 11 (37) ◽  
pp. 6385 ◽  
Author(s):  
Neus Mesquida ◽  
Immaculada Dinarès ◽  
Anna Ibáñez ◽  
Ermitas Alcalde
Keyword(s):  
Anion Binding ◽  
Binding Motifs

scholarly journals Efficient Capture of Perrhenate and Pertechnetate by a Mesoporous Zr Metal–Organic Framework and Examination of Anion Binding Motifs

2018 ◽  
Vol 30 (4) ◽  
pp. 1277-1284 ◽  
Author(s):  
Riki J. Drout ◽  
Kenichi Otake ◽  
Ashlee J. Howarth ◽  
Timur Islamoglu ◽  
Lin Zhu ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Anion Binding ◽  
Binding Motifs ◽  
Metal Organic ◽  
Organic Framework

The Ability of Thrombin Inhibitors to Reduce the Thrombin Activity Generated in Plasma on Extrinsic and Intrinsic Activation

1997 ◽  
Vol 77 (03) ◽  
pp. 498-503 ◽  
Author(s):  
D Prasa ◽  
L Svendsen ◽  
J Stürzebecher
Keyword(s):  
Active Site ◽  
Thrombin Generation ◽  
Anion Binding ◽  
Thrombin Inhibitors ◽  
Coagulation System ◽  
Thrombin Activity ◽  
Continuous Registration ◽  
High Concentrations ◽  
20 Nm ◽  
Generation Test

SummaryIn a thrombin generation test with continuous registration of thrombin activity in plasma we studied the ability of a variety of thrombin inhibitors of different type and mechanism of action to influence the activity of thrombin after activation of the coagulation system. Depending on the inhibitor, the peak of thrombin activity is delayed and/or reduced.By blocking the active site of generated thrombin inhibitors cause a concentration dependent reduction of the thrombin peak and inhibit feed-back reactions of thrombin resulting in a delay of thrombin generation. Highly potent synthetic active-site directed inhibitors (Ki ≤ 20 nM) reduce the thrombin activity formed in plasma after extrinsic or intrinsic activation with the same efficiency (IC50 0.1 - 0.6 μM) as hirudin. The delay and reduction of thrombin generation by inhibitors of the anion-binding exosite 1 of thrombin is only attributed to an inhibition of feed-back reactions of thrombin. For a 50% reduction of thrombin activity in plasma by this type of inhibitors relatively high concentrations were determined.

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