scholarly journals Structural basis of ascorbate-dependent iron reduction by human Dcytb involved in intestinal iron absorption

2019 ◽  
Vol 75 (a2) ◽  
pp. e147-e147
Author(s):  
Hiroshi Sugimoto ◽  
Menega Ganasen ◽  
Hiromi Togashi ◽  
Hanae Takeda ◽  
Yoshitsugu Shiro ◽  
...  
Keyword(s):  
Iron Reduction ◽  
Iron Absorption ◽  
Structural Basis ◽  
Intestinal Iron Absorption

The relative importance of luminal and systemic signals in the control of intestinal iron absorption

2001 ◽  
Vol 120 (5) ◽  
pp. A678-A679
Author(s):  
G ANDERSON ◽  
S WILKINS ◽  
T MURPHY ◽  
G CLEGHORN ◽  
D FRAZER
Keyword(s):  
Iron Absorption ◽  
Relative Importance ◽  
Intestinal Iron Absorption ◽  
Systemic Signals

984 Suppression of LPS and IL-6 Signaling By Iron Deficiency Alters Expression of the Intestinal Iron Absorption Regulator Hepcidin

2008 ◽  
Vol 134 (4) ◽  
pp. A-147
Author(s):  
Deepak Darshan ◽  
David M. Frazer ◽  
Sarah J. Wilkins ◽  
Gregory J. Anderson
Keyword(s):  
Iron Deficiency ◽  
Iron Absorption ◽  
Intestinal Iron Absorption

Studies on intestinal iron absorption —a comparative histologic study on rats treated with CCL4 and DL-ethionine

1969 ◽  
Vol 4 (2) ◽  
pp. 158-159
Author(s):  
I. Urushizaki ◽  
M. Fukuda ◽  
T. Kodama ◽  
T. Takazawa
Keyword(s):  
Iron Absorption ◽  
Histologic Study ◽  
Intestinal Iron Absorption

scholarly journals Iron and Zinc Homeostasis and Interactions: Does Enteric Zinc Excretion Cross-Talk with Intestinal Iron Absorption?

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1885 ◽  
Author(s):  
Palsa Kondaiah ◽  
Puneeta Singh Yaduvanshi ◽  
Paul A Sharp ◽  
Raghu Pullakhandam
Keyword(s):  
Iron Absorption ◽  
Iron Status ◽  
The Body ◽  
Zinc Homeostasis ◽  
Iron Accumulation ◽  
Intestinal Cell ◽  
Deficiency Anemia ◽  
Intestinal Iron Absorption ◽  
Tissue Iron ◽  
Iron And Zinc

Iron and zinc are essential micronutrients required for growth and health. Deficiencies of these nutrients are highly prevalent among populations, but can be alleviated by supplementation and food fortification. Cross-sectional studies in humans showed positive association of serum zinc levels with hemoglobin and markers of iron status. Dietary restriction of zinc or intestinal specific conditional knock out of ZIP4 (SLC39A4), an intestinal zinc transporter, in experimental animals demonstrated iron deficiency anemia and tissue iron accumulation. Similarly, increased iron accumulation has been observed in cultured cells exposed to zinc deficient media. These results together suggest a potential role of zinc in modulating intestinal iron absorption and mobilization from tissues. Studies in intestinal cell culture models demonstrate that zinc induces iron uptake and transcellular transport via induction of divalent metal iron transporter-1 (DMT1) and ferroportin (FPN1) expression, respectively. It is interesting to note that intestinal cells are exposed to very high levels of zinc through pancreatic secretions, which is a major route of zinc excretion from the body. Therefore, zinc appears to be modulating the iron metabolism possibly via regulating the DMT1 and FPN1 levels. Herein we critically reviewed the available evidence to hypothesize novel mechanism of Zinc-DMT1/FPN1 axis in regulating intestinal iron absorption and tissue iron accumulation to facilitate future research aimed at understanding the yet elusive mechanisms of iron and zinc interactions.

Mapping the Gene for Sex-Linked Anemia: An Inherited Defect of Intestinal Iron Absorption in the Mouse

Genomics ◽  
1998 ◽  
Vol 48 (1) ◽  
pp. 34-39 ◽  
Author(s):  
Gregory J. Anderson ◽  
Therese L. Murphy ◽  
Lex Cowley ◽  
Betty A. Evans ◽  
June W. Halliday ◽  
...  
Keyword(s):  
Iron Absorption ◽  
Intestinal Iron Absorption

scholarly journals Mechanistic and regulatory aspects of intestinal iron absorption

2014 ◽  
Vol 307 (4) ◽  
pp. G397-G409 ◽  
Author(s):  
Sukru Gulec ◽  
Gregory J. Anderson ◽  
James F. Collins
Keyword(s):  
Iron Homeostasis ◽  
Iron Absorption ◽  
Hereditary Hemochromatosis ◽  
Regulatory Protein ◽  
Whole Body ◽  
Deficiency Anemia ◽  
Inherited Disorders ◽  
Intestinal Iron Absorption ◽  
Body Iron ◽  
Proximal Small Bowel

Iron is an essential trace mineral that plays a number of important physiological roles in humans, including oxygen transport, energy metabolism, and neurotransmitter synthesis. Iron absorption by the proximal small bowel is a critical checkpoint in the maintenance of whole-body iron levels since, unlike most other essential nutrients, no regulated excretory systems exist for iron in humans. Maintaining proper iron levels is critical to avoid the adverse physiological consequences of either low or high tissue iron concentrations, as commonly occurs in iron-deficiency anemia and hereditary hemochromatosis, respectively. Exquisite regulatory mechanisms have thus evolved to modulate how much iron is acquired from the diet. Systemic sensing of iron levels is accomplished by a network of molecules that regulate transcription of the HAMP gene in hepatocytes, thus modulating levels of the serum-borne, iron-regulatory hormone hepcidin. Hepcidin decreases intestinal iron absorption by binding to the iron exporter ferroportin 1 on the basolateral surface of duodenal enterocytes, causing its internalization and degradation. Mucosal regulation of iron transport also occurs during low-iron states, via transcriptional (by hypoxia-inducible factor 2α) and posttranscriptional (by the iron-sensing iron-regulatory protein/iron-responsive element system) mechanisms. Recent studies demonstrated that these regulatory loops function in tandem to control expression or activity of key modulators of iron homeostasis. In health, body iron levels are maintained at appropriate levels; however, in several inherited disorders and in other pathophysiological states, iron sensing is perturbed and intestinal iron absorption is dysregulated. The iron-related phenotypes of these diseases exemplify the necessity of precisely regulating iron absorption to meet body demands.

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