Abstract
Background: Machine learning describes a subfield of artificial intelligence which utilises statistical algorithms to identify patterns in large datasets. Based on previous learning, inferences or predictions can be made given novel data. Alongside its promising potential to revolutionise consumer technology, there has been growing interest in the application of machine learning algorithms to medical practice. The aim of this study is to evaluate the applications of machine learning in Otolaryngology-Head and Neck surgery.Methods: A systematic search of EMBASE, MEDLINE and CENTRAL will be conducted from January 1990 to June 2020. Studies utilising machine learning as a tool for diagnosis, or to predict disease prognosis or post-operative outcomes in the field of Otolaryngology-Head and Neck surgery will be included. The primary outcome of interest is the accuracy of machine learning models for clinical diagnosis, disease prognostication, and in predicting post-operative outcomes. This protocol adheres to the Preferred Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines.Discussion: To our knowledge, this will be the first systematic review to assimilate and critically appraise original research on the applications of machine learning across the field of Otolaryngology-Head and Neck surgery. This review has the potential to inform the current state of this technology and guide future study of machine learning approaches within the specialty.Systematic review registration: PROSPERO CRD42020192493