Visual Dynamic Simulation Based Optimal Scheduling of RCC Dam Construction Management

Author(s):  
Chunju Zhao ◽  
Yihong Zhou ◽  
Hui An
2015 ◽  
Vol 68 (2) ◽  
pp. 341-345 ◽  
Author(s):  
Shutaro Takeda ◽  
Satoshi Konishi ◽  
Yasushi Yamamoto ◽  
Ryuta Kasada ◽  
Shigeki Sakurai

2014 ◽  
Author(s):  
Naresh Acharya ◽  
Chaitanya Baone ◽  
Santosh Veda ◽  
Jing Dai ◽  
Nilanjan Chaudhuri ◽  
...  

2021 ◽  
Vol 12 (5) ◽  
pp. 6915-6932

Stroke is the leading cause of disability and death worldwide. Inhibition of sulfonylurea 1 receptor (SUR1) using glibenclamide previously has been studied in CNS ischemic tissues and faster recovery from stroke injury in different animal models of stroke. Unfortunately, glibenclamide cannot enter the brain through an intact brain membrane (BBB) due to its ionization at physiological pH. Therefore, it was hypothesized that compounds with structural properties similar to glibenclamide but with the ability to penetrate through BBB would be superior to glibenclamide in ischemic stroke. Docking energy and interactions of glibenclamide with SUR1 active site were assessed using AutoDock Vina. NCI databases search engines with limitations for penetration to CNS were used to find the best compounds with desired properties. Then two selected compounds were assessed with dynamic molecular studies. Two compounds called CID-415537 and CID-419074 with docking energies of -10.3 kcal/mol and -11 kcal/mol were identified. CID-415537 was selected as the best compound due to its proper interactions with SUR1 amino acids and stability in molecular dynamic simulation. Based on this study, compound CID-415537 would be a good candidate for a SUR1 inhibitor in ischemic stroke. However, further in vivo investigations are required to confirm these findings.


2018 ◽  
Vol 25 (4) ◽  
pp. 919-935 ◽  
Author(s):  
Deng-hua Zhong ◽  
Han Wu ◽  
Bin-ping Wu ◽  
Yi-chi Zhang ◽  
Pan Yue

2011 ◽  
Vol 148-149 ◽  
pp. 837-841
Author(s):  
Dan Zhang ◽  
Yuan Lin Liu ◽  
Hong Tao Li

The level of mobile shot blasting machine analysis, a mechanical model of the projectile with the blade and shot rounds of dynamic simulation model, the model by imposing constraints and external forces, analysis of air resistance, friction, blade length and projectile diameter of throw playing speed. Played by the speed of analysis can throw further analysis of various parameters on the effect of throwing fight.


2002 ◽  
Vol 45 (4-5) ◽  
pp. 413-420 ◽  
Author(s):  
K. Krause ◽  
K. Böcker ◽  
J. Londong

Buchenhofen wastewater treatment plant of Wupperverband (650,000 p.e.) is currently being expanded for targeted nitrogen elimination. In view of the limited space available for extension, an optimized control concept is to be used in order to minimize the number of additional tanks required. This concept was investigated by dynamic simulation based on Activated Sludge Model No. 1. The investigations included a pure feedback control configuration and a configuration combining feedback und feedforward control, considering the influent ammonium load, for aeration. The results show that combined feedforward/feedback control has significant advantages over pure feedback control. In particular, this configuration allows a reduction in the effluent NH4-N peaks, which is especially important because of the low NH4-N limit of 5 mg NH4-N/L in a grab sample.


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