Following the current technological development and informational advancement, more and more physical systems have become interconnected and linked via communication networks. The objective of this work is the development of a Coalitional Distributed Model Predictive Control (C- DMPC) strategy suitable for controlling cyber-physical, multi-agent systems. The motivation behind this endeavour is to design a novel algorithm with a flexible control architecture by combining the advantages of classical DMPC with Coalitional MPC. The simulation results were achieved using a test scenario composed of four dynamically coupled sub-systems, connected through an unidirectional communication topology. The obtained results illustrate that, when the feasibility of the local optimization problem is lost, forming a coalition between neighbouring agents solves this shortcoming and maintains the functionality of the entire system. These findings successfully prove the efficiency and performance of the proposed coalitional DMPC method.