scholarly journals Multisensory early intervention can improve visual function in preterm infants at term equivalent age

2021 ◽  
Author(s):  
Rochelle Lester ◽  
Amanda Kwong ◽  
Alicia Spittle
Keyword(s):  
Early Intervention ◽  
Preterm Infants ◽  
Visual Function ◽  
Equivalent Age

scholarly journals Probabilistic diffusion tractography of the optic radiations and visual function in preterm infants at term equivalent age

Brain ◽  
2008 ◽  
Vol 131 (2) ◽  
pp. 573-582 ◽  
Author(s):  
L. Bassi ◽  
D. Ricci ◽  
A. Volzone ◽  
J. M. Allsop ◽  
L. Srinivasan ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Visual Function ◽  
Diffusion Tractography ◽  
Equivalent Age ◽  
Optic Radiations

scholarly journals Effects of Early Intervention on Visual Function in Preterm Infants: A Randomized Controlled Trial

2020 ◽  
Vol 8 ◽  
Author(s):  
Camilla Fontana ◽  
Agnese De Carli ◽  
Daniela Ricci ◽  
Francesca Dessimone ◽  
Sofia Passera ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Early Intervention ◽  
Preterm Infants ◽  
Visual Function ◽  
Controlled Trial ◽  
Randomized Controlled

Early Electroencephalography Suppression and Postnatal Morbidities Correlate with Cerebral Volume at Term-Equivalent Age in Very Preterm Infants

Neonatology ◽  
2017 ◽  
Vol 113 (1) ◽  
pp. 15-20
Author(s):  
Sverre Wikström ◽  
Holger Hövel ◽  
Ingrid Hansen Pupp ◽  
Vineta Fellman ◽  
Petra S. Hüppi ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Very Preterm Infants ◽  
Equivalent Age ◽  
Very Preterm

scholarly journals Early Intervention in preterm infants modulates LINE-1 promoter methylation and neurodevelopment

2019 ◽  
Author(s):  
Camilla Fontana ◽  
Federica Marasca ◽  
Livia Provitera ◽  
Sara Mancinelli ◽  
Nicola Pesenti ◽  
...  
Keyword(s):  
Early Intervention ◽  
Preterm Infants ◽  
Mouse Brain ◽  
Maternal Care ◽  
Early Life ◽  
Copy Number Variations ◽  
Postnatal Life ◽  
Neurodevelopmental Outcomes ◽  
Term Infants ◽  
Link Type

ABSTRACTBackgroundEarly life adversity exposure impacts preterm infants’ neurodevelopment and early intervention protocols may modulate neurodevelopmental outcomes.Neuronal genomes are plastic in response to environment and mobile genetic elements, including LINE-1 (L1), are source of brain genomic mosaicism. Maternal care during early life regulates L1 methylation and copy number variations (CNVs) in mice. Here, we sought to identify the effects of maternal care and positive multisensory stimulation (Early Intervention) on L1 methylation and neurodevelopment in preterm infants.MethodsVery preterm infants were randomized to receive Standard Care or Early Intervention. L1 methylation was measured at birth and at hospital discharge. At 12 months infants’ neurodevelopment was evaluated with the Griffiths Scales. L1 methylation and CNVs were measured in mouse brain areas at embryonic and postnatal stages.ResultsWe demonstrated that L1 is hypomethylated in preterm versus term infants at birth. Early Intervention contributes to restore L1 methylation and positively modulates neurodevelopment. We showed that L1 methylation is developmentally-regulated in mice, decreasing in early postnatal life stages, which turns into an increased L1 CNVs specifically in hippocampus and cortex.ConclusionsHere we demonstrated that L1 dynamics can be modulated by Early Intervention, in parallel with ameliorated neurodevelopmental outcomes. We further identified a specific developmental window of the fetal mouse brain, sensitive to early life experience, in which L1 dynamics are fine-tuned contributing to shape the brain genomic landscape.Trail RegistrationclinicalTrial.gov (NCT02983513)FundingItalian Ministry of Health (RC 780/03 2017), University of Milan (DISCCO 2015) and INGM internal funding.

Early Intervention Improves Behavioral Outcomes for Preterm Infants: Randomized Controlled Trial

PEDIATRICS ◽  
2011 ◽  
Vol 129 (1) ◽  
pp. e9-e16 ◽  
Author(s):  
S. M. Nordhov ◽  
J. A. Ronning ◽  
S. E. Ulvund ◽  
L. B. Dahl ◽  
P. I. Kaaresen
Keyword(s):  
Randomized Controlled Trial ◽  
Early Intervention ◽  
Preterm Infants ◽  
Controlled Trial ◽  
Behavioral Outcomes ◽  
Randomized Controlled

scholarly journals Altered white matter diffusion anisotropy in normal and preterm infants at term-equivalent age

2008 ◽  
Vol 60 (4) ◽  
pp. 761-767 ◽  
Author(s):  
Stephen E. Rose ◽  
Xanthy Hatzigeorgiou ◽  
Mark W. Strudwick ◽  
Gail Durbridge ◽  
Peter S.W. Davies ◽  
...  
Keyword(s):  
White Matter ◽  
Preterm Infants ◽  
Diffusion Anisotropy ◽  
Equivalent Age

Visual Function in Preterm Infants without Major Retinopathy of Prematurity or Neurological Complications

2012 ◽  
Vol 29 (09) ◽  
pp. 747-754 ◽  
Author(s):  
Nicolaos Kozeis ◽  
Maria Mavromichali ◽  
Vasiliki Soubasi-Griva ◽  
Eleni Agakidou ◽  
Dimitris Zafiriou ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Retinopathy Of Prematurity ◽  
Visual Function ◽  
Neurological Complications
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