Phase I evaluation of pharmacokinetics and tolerability of the HIV‐1 maturation inhibitor GSK3640254 and dolutegravir in healthy adults

British Journal of Clinical Pharmacology ◽

10.1111/bcp.14759 ◽

2021 ◽

Author(s):

Teodora Pene Dumitrescu ◽

Samit R. Joshi ◽

Jianfeng Xu ◽

Thomas J. Greene ◽

Mark Johnson ◽

...

Keyword(s):

Phase I ◽

Healthy Adults ◽

Maturation Inhibitor ◽

Hiv 1

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Phase I evaluation of the safety, tolerability, and pharmacokinetics of GSK3640254, a next‐generation HIV‐1 maturation inhibitor

Pharmacology Research & Perspectives ◽

10.1002/prp2.671 ◽

2020 ◽

Vol 8 (6) ◽

Author(s):

Samit R. Joshi ◽

Disala Fernando ◽

Stephanie Igwe ◽

Litza McKenzie ◽

Anu S. Krishnatry ◽

...

Keyword(s):

Phase I ◽

Next Generation ◽

Maturation Inhibitor ◽

Hiv 1

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A phase I study of high dose camostat mesylate in healthy adults provides a rationale to repurpose the TMPRSS2 inhibitor for the treatment of COVID‐19

Clinical and Translational Science ◽

10.1111/cts.13052 ◽

2021 ◽

Author(s):

Junsaku Kitagawa ◽

Hayato Arai ◽

Hiroyuki Iida ◽

Jiro Mukai ◽

Kenji Furukawa ◽

...

Keyword(s):

Phase I ◽

Phase I Study ◽

Healthy Adults ◽

High Dose

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Pharmacokinetics and Pharmacodynamics of Itepekimab in Healthy Adults and Patients With Asthma: Phase I First‐in‐Human and First‐in‐Patient Trials

Clinical and Translational Science ◽

10.1111/cts.13157 ◽

2021 ◽

Author(s):

Matthew P. Kosloski ◽

George D. Kalliolias ◽

Christine R. Xu ◽

Sivan Harel ◽

Ching‐Ha Lai ◽

...

Keyword(s):

Phase I ◽

Healthy Adults ◽

Pharmacokinetics And Pharmacodynamics

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Safety and Immunogenicity of a rAd35-EnvA Prototype HIV-1 Vaccine in Combination with rAd5-EnvA in Healthy Adults (VRC 012)

PLoS ONE ◽

10.1371/journal.pone.0166393 ◽

2016 ◽

Vol 11 (11) ◽

pp. e0166393 ◽

Cited By ~ 3

Author(s):

Michelle C. Crank ◽

Eleanor M. P. Wilson ◽

Laura Novik ◽

Mary E. Enama ◽

Cynthia S. Hendel ◽

...

Keyword(s):

Healthy Adults ◽

Hiv 1

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The Effect of Verapamil, a P-gp Inhibitor, on the Pharmacokinetics, Safety, and Tolerability of Omadacycline in Healthy Adults: A Phase I, Open-Label, Single-Sequence Study

European Journal of Drug Metabolism and Pharmacokinetics ◽

10.1007/s13318-020-00651-3 ◽

2020 ◽

Author(s):

Thomas L. Hunt ◽

Evan Tzanis ◽

Stephen Bai ◽

Amy Manley ◽

Surya Chitra ◽

...

Keyword(s):

Phase I ◽

Healthy Adults ◽

Open Label ◽

Sequence Study ◽

Single Sequence

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P14-12. Safety and tolerability of VRC DNA and rAd5 HIV-1 vaccine delivery by intramuscular, subcutaneous and intradermal administration in healthy adults

Retrovirology ◽

10.1186/1742-4690-6-s3-p200 ◽

2009 ◽

Vol 6 (S3) ◽

Author(s):

ME Enama ◽

L Novik ◽

L Holman ◽

I Gordon ◽

M Nason ◽

...

Keyword(s):

Vaccine Delivery ◽

Healthy Adults ◽

Intradermal Administration ◽

Hiv 1

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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects of PF-06751979, a Potent and Selective Oral BACE1 Inhibitor: Results from Phase I Studies in Healthy Adults and Healthy Older Subjects

Journal of Alzheimer s Disease ◽

10.3233/jad-190228 ◽

2019 ◽

Vol 71 (2) ◽

pp. 581-595 ◽

Cited By ~ 4

Author(s):

Ruolun Qiu ◽

Jae Eun Ahn ◽

Robert Alexander ◽

Michael A. Brodney ◽

Ping He ◽

...

Keyword(s):

Phase I ◽

Healthy Adults ◽

Phase I Studies ◽

Bace1 Inhibitor ◽

Pharmacodynamic Effects ◽

Older Subjects

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A live attenuated H7N3 influenza virus vaccine is well tolerated and immunogenic in a Phase I trial in healthy adults

Vaccine ◽

10.1016/j.vaccine.2009.03.082 ◽

2009 ◽

Vol 27 (28) ◽

pp. 3744-3753 ◽

Cited By ~ 80

Author(s):

Kawsar R. Talaat ◽

Ruth A. Karron ◽

Karen A. Callahan ◽

Catherine J. Luke ◽

Susan C. DiLorenzo ◽

...

Keyword(s):

Influenza Virus ◽

Phase I ◽

Virus Vaccine ◽

Phase I Trial ◽

Influenza Virus Vaccine ◽

Healthy Adults

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Phase I study on safety and pharmacokinetics of a novel influenza endonuclease inhibitor, AL-794 (JNJ-64155806), following single- and multiple-ascending doses in healthy adults

Antiviral Therapy ◽

10.3851/imp3244 ◽

2018 ◽

Vol 23 (7) ◽

pp. 555-566 ◽

Cited By ~ 2

Author(s):

Thomas N Kakuda ◽

Jeysen Yogaratnam ◽

Jennifer Rito ◽

Malcolm Boyce ◽

Toni Mitchell ◽

...

Keyword(s):

Phase I ◽

Phase I Study ◽

Healthy Adults

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The HIV-1 maturation inhibitor, EP39, interferes with the dynamic helix-coil equilibrium of the CA-SP1 junction of Gag

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112634 ◽

2020 ◽

Vol 204 ◽

pp. 112634

Author(s):

Xiaowei Chen ◽

Pascale Coric ◽

Valery Larue ◽

Serge Turcaud ◽

Xiao Wang ◽

...

Keyword(s):

Maturation Inhibitor ◽

Hiv 1

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