The Acid Test: Proton Pump Inhibitors in Persistent Throat Symptoms: A Systematic Review of Systematic Reviews

2021 ◽  
Author(s):  
Benjamin Cosway ◽  
Janet A Wilson ◽  
James O’Hara
Keyword(s):  
Systematic Review ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Systematic Reviews ◽  
Acid Test

scholarly journals Comparison of common interventions for the treatment of infantile colic: a systematic review of reviews and guidelines

BMJ Open ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. e035405 ◽  
Author(s):  
Julie Ellwood ◽  
Jerry Draper-Rodi ◽  
Dawn Carnes
Keyword(s):  
Systematic Review ◽  
Adverse Events ◽  
Proton Pump Inhibitors ◽  
Manual Therapy ◽  
Proton Pump ◽  
Systematic Reviews ◽  
Time Range ◽  
National Guidelines ◽  
Infant Crying ◽  
Breastfed Infants

ObjectiveTo conduct a systematic review of systematic reviews and national guidelines to assess the effectiveness of four treatment approaches (manual therapy, probiotics, proton pump inhibitors and simethicone) on colic symptoms including infant crying time, sleep distress and adverse events.MethodsWe searched PubMed, Embase, Cochrane and Mantis for studies published between 2009 and 2019. Inclusion criteria were systematic reviews and guidelines that used evidence and expert panel opinion. Three reviewers independently selected articles by title, abstract and full paper review. Data were extracted by one reviewer and checked by a second. Selected studies were assessed for quality using modified standardised checklists by two authors. Meta-analysed data for our outcomes of interest were extracted and narrative conclusions were assessed.ResultsThirty-two studies were selected. High-level evidence showed that probiotics were most effective for reducing crying time in breastfed infants (range −25 min to −65 min over 24 hours). Manual therapies had moderate to low-quality evidence showing reduced crying time (range −33 min to −76 min per 24 hours). Simethicone had moderate to low evidence showing no benefit or negative effect. One meta-analysis did not support the use of proton pump inhibitors for reducing crying time and fussing. Three national guidelines unanimously recommended the use of education, parental reassurance, advice and guidance and clinical evaluation of mother and baby. Consensus on other advice and treatments did not exist.ConclusionsThe strongest evidence for the treatment of colic was probiotics for breastfed infants, followed by weaker but favourable evidence for manual therapy indicated by crying time. Both forms of treatment carried a low risk of serious adverse events. The guidance reviewed did not reflect these findings.PROSPERO registration numberCRD42019139074.

scholarly journals EFFECT OF PROTON PUMP INHIBITORS ON CLINICAL OUTCOME IN PATIENTS TREATED WITH CLOPIDOGREL: A SYSTEMATIC REVIEW AND META-ANALYSIS

2010 ◽  
Vol 55 (10) ◽  
pp. A206.E1943
Author(s):  
Jolanta M. Siller-Matula ◽  
Bernd Jilma ◽  
Karsten Schrö;r ◽  
Guenter Christ ◽  
Kurt Huber
Keyword(s):  
Systematic Review ◽  
Clinical Outcome ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Meta Analysis

No Effect of Proton Pump Inhibitors on Crying and Irritability in Infants: Systematic Review of Randomized Controlled Trials

2015 ◽  
Vol 166 (3) ◽  
pp. 767-770.e3 ◽  
Author(s):  
Dorota Gieruszczak-Białek ◽  
Zofia Konarska ◽  
Agata Skórka ◽  
Yvan Vandenplas ◽  
Hania Szajewska
Keyword(s):  
Systematic Review ◽  
Randomized Controlled Trials ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Controlled Trials ◽  
Randomized Controlled

scholarly journals Long-term proton pump inhibitor use and the incidence of gastric cancer: A systematic review and meta-analysis

2020 ◽  
Vol 2 (1) ◽  
pp. 1-11
Author(s):  
Ju-Li Lin ◽  
Jian-Xian Lin ◽  
Chao-Hui Zheng ◽  
Jian-Wei Xie ◽  
Jia-bin Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Systematic Review ◽  
Proton Pump Inhibitor ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Meta Analysis ◽  
Inclusion Criteria ◽  
Risk Ratios

Background: There are controverted whether the long-term use of proton pump inhibitors (PPI) will increase the risk of gastric cancer. We performed a meta-analysis to assess the risk of gastric cancer in PPI users compared with non-PPI users. Methods: The main inclusion criteria were original studies reporting the incidence of gastric cancer in PPI users compared with non-PPI users. Key outcomes were the risk ratios (RR) for gastric cancer in association with PPI users or non-PPI users. Results: We analyzed data from 8 studies, comprising more than 927,684 patients. The risk of gastric cancer in PPI users was significantly higher than in non-PPI users [RR= 2.10, 95% CI (1.17-3.97)]. The risk of gastric cancer was similar between the 2 groups when the duration was ≤1 year [RR= 2.18, 95% CI (0.66-7.11)]. While the risk of gastric cancer for PPI users was higher than in non-PPI users when the duration was between 1-3 years, ≥1 year, ≥3 years and ≥5 years. The risk of non-cardiac gastric cancer for PPI users was higher than for non-PPI users [RR= 2.66, 95% CI (1.66 -4.27)], and the risk of non-cardiac gastric cancer for PPI users was higher than for non-PPI users when the duration ≥1 year [RR= 1.99, 95% CI (1.03-3.83)], but the risk for cardiac gastric cancer was similar between the 2 groups [RR= 1.86, 95% CI (0.71-4.89)]. Conclusions: We found the long-term use of PPI (duration ≥1 year) was significantly associated with a higher risk of non-cardiac gastric cancer.

scholarly journals Do proton pump inhibitors increase mortality? A systematic review and in-depth analysis of the evidence

Authorea ◽  
2020 ◽  
Author(s):  
Mohamed Ben Eltriki ◽  
Carolyn Green ◽  
Malcolm Maclure ◽  
Vijaya Musini ◽  
Ken Bassett ◽  
...  
Keyword(s):  
Systematic Review ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Depth Analysis
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