Real world performance of hybrid closed loop in youth, young adults, adults and older adults with type 1 diabetes: Identifying a clinical target for hybrid closed loop use

2021 ◽  
Author(s):  
Cari Berget ◽  
Halis Kaan Akturk ◽  
Laurel H Messer ◽  
Timothy Vigers ◽  
Laura Pyle ◽  
...  
Keyword(s):  
Older Adults ◽  
Type 1 Diabetes ◽  
Young Adults ◽  
Real World ◽  
Closed Loop

147-OR: Use of Closed-Loop Insulin Therapy in Older Adults with Type 1 Diabetes: Real-World Experience

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 147-OR
Author(s):  
ELENA TOSCHI ◽  
CHRISTINE SLYNE ◽  
ASTRID ATAKOV-CASTILLO ◽  
MEDHA MUNSHI
Keyword(s):  
Older Adults ◽  
Type 1 Diabetes ◽  
Insulin Therapy ◽  
Real World ◽  
Closed Loop

Closed-Loop Insulin Therapy in older adults with Type 1 Diabetes: real-world data

2021 ◽  
Author(s):  
Elena Toschi ◽  
Astrid Atakov-Castillo ◽  
Christine Slyne ◽  
Medha Munshi
Keyword(s):  
Older Adults ◽  
Type 1 Diabetes ◽  
Insulin Therapy ◽  
Real World ◽  
Closed Loop ◽  
Real World Data ◽  
World Data

717-P: Real-World, Patient-Reported Data on Training and Use of 670G Hybrid Closed-Loop (HCL) among Children and Adults with Type 1 Diabetes (T1D)

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 717-P
Author(s):  
COLLEEN BAUZA ◽  
STEPHANIE DUBOSE ◽  
ALANDRA VERDEJO ◽  
ROY BECK ◽  
RICHARD M. BERGENSTAL ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Real World ◽  
Closed Loop ◽  
Patient Reported ◽  
Reported Data

scholarly journals Closed-Loop Insulin Delivery Versus Sensor-Augmented Pump Therapy in Older Adults With Type 1 Diabetes (ORACL): A Randomized, Crossover Trial

Diabetes Care ◽  
2021 ◽  
pp. dc211667
Author(s):  
Sybil A. McAuley ◽  
Steven Trawley ◽  
Sara Vogrin ◽  
Glenn M. Ward ◽  
Spiros Fourlanos ◽  
...  
Keyword(s):  
Older Adults ◽  
Type 1 Diabetes ◽  
Closed Loop ◽  
Crossover Trial ◽  
Insulin Delivery ◽  
Pump Therapy ◽  
Randomized Crossover Trial

976-P: Evaluation of Hybrid Closed-Loop Insulin Delivery System for Patients with Type 1 Diabetes in Real-World Clinical Practice: A One-Year Qualitative Observational Study

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 976-P
Author(s):  
AHMED H. ELDIB ◽  
SHAHEEN TOMAH ◽  
SHILTON E. DHAVER ◽  
HANNAH GARDNER ◽  
MHD WAEL TASABEHJI ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Clinical Practice ◽  
Observational Study ◽  
Delivery System ◽  
Real World ◽  
Closed Loop ◽  
Insulin Delivery ◽  
Insulin Delivery System ◽  
One Year

212-OR: Closed-Loop Increases Time-in-Range in Older Adults with Type 1 Diabetes Compared with Sensor-Augmented Pump Therapy: A Randomized Crossover Trial

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 212-OR
Author(s):  
SYBIL A. MCAULEY ◽  
SARA VOGRIN ◽  
STEVEN TRAWLEY ◽  
PETER G. COLMAN ◽  
SPIROS FOURLANOS ◽  
...  
Keyword(s):  
Older Adults ◽  
Type 1 Diabetes ◽  
Closed Loop ◽  
Crossover Trial ◽  
Pump Therapy ◽  
Randomized Crossover Trial ◽  
Time In Range

Age is a determinant of acute hemodynamic responses to hyperglycemia and angiotensin II in humans with uncomplicated type 1 diabetes mellitus

2010 ◽  
Vol 299 (1) ◽  
pp. R206-R214 ◽  
Author(s):  
David Z. I. Cherney ◽  
Heather N. Reich ◽  
Judith A. Miller ◽  
Vesta Lai ◽  
Bernard Zinman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Type 1 Diabetes ◽  
Young Adults ◽  
Vascular Dysfunction ◽  
Ang Ii ◽  
Hemodynamic Responses ◽  
Hemodynamic Function ◽  
Type 1 Dm

Hyperglycemia is associated with hemodynamic changes in type 1 diabetes (DM), acting in part through renin-angiotensin system activation. Since aging is associated with vascular dysfunction in DM, we hypothesized that acute hemodynamic responses to clamped hyperglycemia and infused ANG II would be exaggerated in older adults compared with a group of adolescent/young adults with type 1 DM. Renal hemodynamic function, blood pressure, and arterial stiffness were assessed in adolescent/young adults ( n = 34; mean age: 18 ± 3 yr) and older adults ( n = 32; mean age: 45 ± 9 yr). Studies were performed during clamped euglycemia (4–6 mmol/l) and hyperglycemia (9–11 mmol/l). Renal and systemic hemodynamic responses to ANG II were measured during clamped euglycemia in diabetic subjects. ANG II responses were also assessed in a cohort of non-DM subjects ( n = 97; mean age: 26; age range: 18–40 yr). Older DM adults exhibited higher baseline blood pressure, arterial stiffness, and renal vascular resistance, and lower glomerular filtration rate (GFR) and effective renal plasma flow, compared with adolescent/young DM adults ( P < 0.05). Clamped hyperglycemia was associated with exaggerated peripheral and renal hemodynamic responses uniquely in older DM adults; only GFR increased in adolescent/young DM adults. ANG II infusion also produced exaggerated vasoconstrictive responses in older DM adults vs. adolescent/young DM adults ( P < 0.05). The independent effect of age on hemodynamic responses to hyperglycemia and ANG II was confirmed using multivariate regression analysis in DM subjects ( P < 0.05), and results were still significant when participants were matched for DM duration. Age-related alterations in hemodynamic function and ANG II response were not observed in healthy non-DM control subjects. Acute hemodynamic responses to clamped hyperglycemia and ANG II were exaggerated in older subjects with type 1 DM, highlighting an important interaction between age and factors that contribute to the pathogenesis of acute vascular dysfunction in DM.

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