“ Do I still have epilepsy? ” Epilepsy identity 15–20 years after anterior temporal lobectomy

Epilepsia ◽  
2021 ◽  
Author(s):  
Honor Coleman ◽  
Anne McIntosh ◽  
Sarah J. Wilson
Keyword(s):  
Temporal Lobectomy ◽  
Anterior Temporal Lobectomy

scholarly journals Stereotactic EEG-guided radiofrequency thermocoagulation versus anterior temporal lobectomy for mesial temporal lobe epilepsy with hippocampal sclerosis: study protocol for a randomised controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Yi-He Wang ◽  
Si-Chang Chen ◽  
Peng-Hu Wei ◽  
Kun Yang ◽  
Xiao-Tong Fan ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Hippocampal Sclerosis ◽  
Controlled Trial ◽  
Mesial Temporal Lobe Epilepsy ◽  
Temporal Lobectomy ◽  
Anterior Temporal Lobectomy ◽  
Radiofrequency Thermocoagulation ◽  
Mesial Temporal Lobe ◽  
Randomised Controlled

Abstract Introduction In this report, we aim to describe the design for the randomised controlled trial of Stereotactic electroencephalogram (EEG)-guided Radiofrequency Thermocoagulation versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (STARTS). Mesial temporal lobe epilepsy (mTLE) is a classical subtype of temporal lobe epilepsy that often requires surgical intervention. Although anterior temporal lobectomy (ATL) remains the most popular treatment for mTLE, accumulating evidence has indicated that ATL can cause tetartanopia and memory impairments. Stereotactic EEG (SEEG)-guided radiofrequency thermocoagulation (RF-TC) is a non-invasive alternative associated with lower seizure freedom but greater preservation of neurological function. In the present study, we aim to compare the safety and efficacy of SEEG-guided RF-TC and classical ATL in the treatment of mTLE. Methods and analysis STARTS is a single-centre, two-arm, randomised controlled, parallel-group clinical trial. The study includes patients with typical mTLE over the age of 14 who have drug-resistant seizures for at least 2 years and have been determined via detailed evaluation to be surgical candidates prior to randomisation. The primary outcome measure is the cognitive function at the 1-year follow-up after treatment. Seizure outcomes, visual field abnormalities after surgery, quality of life, ancillary outcomes, and adverse events will also be evaluated at 1-year follow-up as secondary outcomes. Discussion SEEG-guided RF-TC for mTLE remains a controversial seizure outcome but has the advantage for cognitive and visual field protection. This is the first RCT studying cognitive outcomes and treatment results between SEEG-guided RF-TC and standard ATL for mTLE with hippocampal sclerosis. This study may provide higher levels of clinical evidence for the treatment of mTLE. Trial registration ClinicalTrials.gov NCT03941613. Registered on May 8, 2019. The STARTS protocol has been registered on the US National Institutes of Health. The status of the STARTS was recruiting and the estimated study completion date was December 31, 2021.

scholarly journals Memory, Emotional and Vocational Impairments before and after Anterior Temporal Lobectomy for Complex Partial Seizures

Epilepsia ◽  
2006 ◽  
Vol 47 (11) ◽  
pp. 1922-1930 ◽  
Author(s):  
Mario F. Dulay ◽  
Michele K. York ◽  
Elizabeth M. Soety ◽  
Winifred J. Hamilton ◽  
Eli M. Mizrahi ◽  
...  
Keyword(s):  
Temporal Lobectomy ◽  
Partial Seizures ◽  
Complex Partial Seizures ◽  
Anterior Temporal Lobectomy ◽  
Before And After

scholarly journals Post-operative nonketotic hyperglycemic induced focal motor status epilepticus related to treatment with corticosteroids following standard anterior temporal lobectomy

2018 ◽  
Vol 10 ◽  
pp. 124-128 ◽  
Author(s):  
Andrew Zillgitt ◽  
Abdullah Alshammaa ◽  
Muhammad Salim Kahn ◽  
Sarah Madani ◽  
Salman Zahoor ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Temporal Lobectomy ◽  
Anterior Temporal Lobectomy

Prognostic importance of serial postoperative EEGs after anterior temporal lobectomy

Neurology ◽  
2011 ◽  
Vol 76 (22) ◽  
pp. 1925-1931 ◽  
Author(s):  
C. Rathore ◽  
S. P. Sarma ◽  
K. Radhakrishnan
Keyword(s):  
Temporal Lobectomy ◽  
Anterior Temporal Lobectomy ◽  
Prognostic Importance

scholarly journals Anterior temporal lobectomy versus selective amygdalohippocampectomy in patients with mesial temporal lobe epilepsy

2015 ◽  
Vol 74 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Fábio A. Nascimento ◽  
Luana Antunes Maranha Gatto ◽  
Carlos Silvado ◽  
Maria Joana Mäder-Joaquim ◽  
Marlus Sidney Moro ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Mesial Temporal Lobe Epilepsy ◽  
Temporal Lobectomy ◽  
Mesial Temporal Sclerosis ◽  
Anterior Temporal Lobectomy ◽  
Selective Amygdalohippocampectomy ◽  
Significant Difference ◽  
Mesial Temporal Lobe ◽  
Neuropsychological Outcomes

ABSTRACT Objective To contribute our experience with surgical treatment of patients with mesial temporal lobe epilepsy (mTLE) undergoing anterior temporal lobectomy (ATL) or selective amygdalohippocampectomy (SelAH). Method This is a retrospective observational study. The sample included patients with medically refractory mTLE due to unilateral mesial temporal sclerosis who underwent either ATL or SelAH, at Hospital de Clinicas – UFPR, from 2005 to 2012. We report seizure outcomes, using Engel classification, cognitive outcomes, using measurements of verbal and visuospatial memories, as well as operative complications. Result Sixty-seven patients (33 ATL, 34 SelAH) were studied; median follow-up was 64 months. There was no statistically significant difference in seizure or neuropsychological outcomes, although verbal memory was more negatively affected in ATL operations on patients’ dominant hemispheres. Higher number of major complications was observed in the ATL group (p = 0.004). Conclusion Seizure and neuropsychological outcomes did not differ. ATL appeared to be associated with higher risk of complications.

Differences between nouns and verbs after anterior temporal lobectomy.

2001 ◽  
Vol 15 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Guila Glosser ◽  
Nancy Donofrio
Keyword(s):  
Temporal Lobectomy ◽  
Anterior Temporal Lobectomy

scholarly journals Memory outcome 2 years after anterior temporal lobectomy in patients with drug-resistant epilepsy

Seizure ◽  
2009 ◽  
Vol 18 (2) ◽  
pp. 139-144 ◽  
Author(s):  
Liliana G. Grammaldo ◽  
Giancarlo Di Gennaro ◽  
Teresa Giampà ◽  
Marco De Risi ◽  
Giulio N. Meldolesi ◽  
...  
Keyword(s):  
Temporal Lobectomy ◽  
Drug Resistant ◽  
Anterior Temporal Lobectomy ◽  
Drug Resistant Epilepsy
Sign in / Sign up

Export Citation Format

Share Document