scholarly journals Instructive roles of astrocytes in hippocampal synaptic plasticity: neuronal activity‐dependent regulatory mechanisms

FEBS Journal ◽  
2021 ◽  
Author(s):  
Ye Wang ◽  
Amy K.Y. Fu ◽  
Nancy Y. Ip
Keyword(s):  
Synaptic Plasticity ◽  
Neuronal Activity ◽  
Regulatory Mechanisms ◽  
Hippocampal Synaptic Plasticity ◽  
Activity Dependent

scholarly journals Activity-dependent modulation of hippocampal synaptic plasticity via PirB and endocannabinoids

2018 ◽  
Vol 24 (8) ◽  
pp. 1206-1219 ◽  
Author(s):  
Maja Djurisic ◽  
Barbara K. Brott ◽  
Nay L. Saw ◽  
Mehrdad Shamloo ◽  
Carla J. Shatz
Keyword(s):  
Synaptic Plasticity ◽  
Hippocampal Synaptic Plasticity ◽  
Activity Dependent

Remodeling of astrocytes, a prerequisite for synapse turnover in the adult brain? Insights from the oxytocin system of the hypothalamus

2006 ◽  
Vol 290 (5) ◽  
pp. R1175-R1182 ◽  
Author(s):  
Dionysia T. Theodosis ◽  
Andrei Trailin ◽  
Dominique A. Poulain
Keyword(s):  
Synaptic Plasticity ◽  
Synaptic Transmission ◽  
Neuronal Activity ◽  
Adult Brain ◽  
Synaptic Connectivity ◽  
Excitatory Synapses ◽  
Neuronal Function ◽  
Physiological Conditions ◽  
Baseline Levels ◽  
Activity Dependent

Neurons, including their synapses, are generally ensheathed by fine processes of astrocytes, but this glial coverage can be altered under different physiological conditions that modify neuronal activity. Changes in synaptic connectivity accompany astrocytic transformations so that an increased number of synapses are associated with reduced astrocytic coverage of postsynaptic elements, whereas synaptic numbers are reduced on reestablishment of glial coverage. A system that exemplifies activity-dependent structural synaptic plasticity in the adult brain is the hypothalamo-neurohypophysial system, and in particular, its oxytocin component. Under strong, prolonged activation (parturition, lactation, chronic dehydration), extensive portions of somatic and dendritic surfaces of magnocellular oxytocin neurons are freed of intervening astrocytic processes and become directly juxtaposed. Concurrently, they are contacted by an increased number of inhibitory and excitatory synapses. Once stimulation is over, astrocytic processes again cover oxytocinergic surfaces and synaptic numbers return to baseline levels. Such observations indicate that glial ensheathment of neurons is of consequence to neuronal function, not only directly, for example by modifying synaptic transmission, but indirectly as well, by preparing neuronal surfaces for synapse turnover.

scholarly journals Activity-Dependent Rapid Local RhoA Synthesis Is Required for Hippocampal Synaptic Plasticity

2015 ◽  
Vol 35 (5) ◽  
pp. 2269-2282 ◽  
Author(s):  
V. Briz ◽  
G. Zhu ◽  
Y. Wang ◽  
Y. Liu ◽  
M. Avetisyan ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Hippocampal Synaptic Plasticity ◽  
Activity Dependent

Malfunctional Reorganization in the Developing Limbo-Prefrontal System in Animals: Implications for Human Psychoses?

2001 ◽  
Vol 12 (1) ◽  
pp. 8-14
Author(s):  
Gertraud Teuchert-Noodt ◽  
Ralf R. Dawirs
Keyword(s):  
Prefrontal Cortex ◽  
Mental Disorders ◽  
Dentate Gyrus ◽  
Cognitive Functions ◽  
Experimental Approach ◽  
Regulatory Mechanisms ◽  
Hippocampal Dentate Gyrus ◽  
Non Invasive ◽  
Invasive Method ◽  
Activity Dependent

Abstract: Neuroplasticity research in connection with mental disorders has recently bridged the gap between basic neurobiology and applied neuropsychology. A non-invasive method in the gerbil (Meriones unguiculus) - the restricted versus enriched breading and the systemically applied single methamphetamine dose - offers an experimental approach to investigate psychoses. Acts of intervening affirm an activity dependent malfunctional reorganization in the prefrontal cortex and in the hippocampal dentate gyrus and reveal the dopamine position as being critical for the disruption of interactions between the areas concerned. From the extent of plasticity effects the probability and risk of psycho-cognitive development may be derived. Advance may be expected from insights into regulatory mechanisms of neurogenesis in the hippocampal dentate gyrus which is obviously to meet the necessary requirements to promote psycho-cognitive functions/malfunctions via the limbo-prefrontal circuit.

Sign in / Sign up

Export Citation Format

Share Document