Physical characterization andin vitroskin permeation of solid lipid nanoparticles for transdermal delivery of quercetin

The aim of present study was to construct and investigate the efficacy of solid lipid nanoparticles (SLNs) based hydrogel for transdermal delivery of non-steroidal anti-inflammatory drug (NSAID) piroxicam. Solid lipid nanoparticles (SLNs) of piroxicam were produced by solvent emulsification diffusion method in a solvent saturated system. The SLNs were composed of tripalmitin lipid, polyvinyl alcohol (PVA) as stabilizer, and solvent ethyl acetate. All the formulations were subjected to particle size analysis, zeta potential, drug entrapment efficiency, percent drug loading determination and in-vitro release studies. The SLNs formed were in nano-size range with maximum entrapment efficiency of 88.50±0.92. Further, Carbopol-934 was used as a gel matrix for preparation of hydrogel for improving the penetration rate across the skin and viscosity of piroxicam loaded SLNs for transdermal drug administration. The drug release behaviors from piroxicam loaded SLNs based hydrogel exhibited long duration and constant rate of drug release over 24 hr. Skin penetration of piroxicam loaded SLNs based hydrogel was assessed by confocal laser scanning microscopy (CLSM).

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Ceramide–palmitic acid complex based Curcumin solid lipid nanoparticles for transdermal delivery: pharmacokinetic and pharmacodynamic study

Journal of Experimental Nanoscience ◽

10.1080/17458080.2015.1025301 ◽

2015 ◽

Vol 11 (1) ◽

pp. 38-53 ◽

Cited By ~ 7

Author(s):

Praveen Kumar Gaur ◽

Shikha Mishra ◽

Anurag Verma ◽

Navneet Verma

Keyword(s):

Palmitic Acid ◽

Transdermal Delivery ◽

Solid Lipid Nanoparticles ◽

Lipid Nanoparticles ◽

Acid Complex ◽

Solid Lipid ◽

Pharmacodynamic Study

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Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery

Acta Pharmaceutica ◽

10.1515/acph-2015-0009 ◽

2015 ◽

Vol 65 (1) ◽

pp. 1-13 ◽

Cited By ~ 29

Author(s):

Ümit Gönüllü ◽

Melike Üner ◽

Gülgün Yener ◽

Ecem Fatma Karaman ◽

Zeynep Aydoğmuş

Keyword(s):

Transdermal Delivery ◽

Solid Lipid Nanoparticles ◽

Lipid Nanoparticles ◽

Nanostructured Lipid Carriers ◽

Drug Penetration ◽

Rat Skin ◽

Drug Diffusion ◽

Solid Lipid ◽

Inflammatory Conditions

Abstract Solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and nanoemulsion (NE) of lornoxicam (LRX) were prepared for the treatment of painful and inflammatory conditions of the skin. Compritol® 888 ATO, Lanette® O and oleic acid were used as solid and liquid lipids. SLN, NLC and NE were found physically stable at various temperatures for 6 months. Case I diffusional drug release was detected as the dominant mechanism indicating Fickian drug diffusion from nanoparticles and nanoemulsion. The highest rate of drug penetration through rat skin was obtained with NE followed by NLC, SLN and a gel formulation. Nanoformulations significantly increased drug penetration through rat skin compared to the gel (p < 0.05). Thus, SLN, NLC and NE of LRX can be suggested for relieving painful and inflammatory conditions of the skin

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