scholarly journals Close Correlation between the Dephosphorylation of p53 and Growth Suppression by Transforming Growth Factor-β1 in Nasopharyngeal Carcinoma Cells Transduced with Adenovirus Early Region Genes

1994 ◽  
Vol 85 (5) ◽  
pp. 459-463 ◽  
Author(s):  
Yoshihiro Mogi ◽  
Junji Kato ◽  
Masayoshi Horimoto ◽  
Rishu Takimoto ◽  
Tsuzuku Murakami ◽  
...  
Keyword(s):  
Growth Factor ◽  
Nasopharyngeal Carcinoma ◽  
Transforming Growth Factor ◽  
Close Correlation ◽  
Transforming Growth Factor Β1 ◽  
Growth Suppression ◽  
Carcinoma Cells ◽  
Early Region

scholarly journals Long non-coding (lnc)RNA profiling and the role of a key regulator lnc-PNRC2-1 in the transforming growth factor-β1-induced epithelial–mesenchymal transition of CNE1 nasopharyngeal carcinoma cells

2021 ◽  
Vol 49 (3) ◽  
pp. 030006052199651
Author(s):  
Jie Yang ◽  
Enzi Feng ◽  
Yanxin Ren ◽  
Shun Qiu ◽  
Liufang Zhao ◽  
...  
Keyword(s):  
Growth Factor ◽  
Nasopharyngeal Carcinoma ◽  
Rna Sequencing ◽  
Western Blotting ◽  
Transforming Growth Factor ◽  
Epithelial Mesenchymal Transition ◽  
Carcinoma Cells ◽  
Mesenchymal Transition ◽  
Emt Markers ◽  
Tgf Β1

Objectives To identify key long non-coding (lnc)RNAs responsible for the epithelial–mesenchymal transition (EMT) of CNE1 nasopharyngeal carcinoma cells and to investigate possible regulatory mechanisms in EMT. Methods CNE1 cells were divided into transforming growth factor (TGF)-β1-induced EMT and control groups. The mRNA and protein expression of EMT markers was determined by real-time quantitative PCR and western blotting. Differentially expressed genes (DEGs) between the two groups were identified by RNA sequencing analysis, and DEG functions were analyzed by gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses. EMT marker expression was re-evaluated by western blotting after knockdown of a selected lncRNA. Results TGF-β1-induced EMT was characterized by decreased E-cadherin and increased vimentin, N-cadherin, and Twist expression at both mRNA and protein levels. Sixty lncRNA genes were clustered in a heatmap, and mRNA expression of 14 dysregulated lncRNAs was consistent with RNA sequencing. Knockdown of lnc-PNRC2-1 increased expression of its antisense gene MYOM3 and reduced expression of EMT markers, resembling treatment with the TGF-β1 receptor inhibitor LY2109761. Conclusion Various lncRNAs participated indirectly in the TGF-β1-induced EMT of CNE1 cells. Lnc-PNRC2-1 may be a key regulator of this and is a potential target to alleviate CNE1 cell EMT.

scholarly journals Mouse forestomach carcinoma cells immunosuppress macrophages through transforming growth factor-β1

2012 ◽  
Vol 5 (4) ◽  
pp. 988-992 ◽  
Author(s):  
HUAXING LUO ◽  
YINGXUE HAO ◽  
BO TANG ◽  
DONGZHU ZENG ◽  
YAN SHI ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Carcinoma Cells

An interaction between human colon carcinoma cells and hepatocytes activates transforming growth factor-β1 in vitro

1999 ◽  
Vol 142 (1) ◽  
pp. 83-89 ◽  
Author(s):  
Hideki Nishibori ◽  
Masahiko Watanabe ◽  
Shin Narai ◽  
Tetsuro Kubota ◽  
Chitose Matsubara ◽  
...  
Keyword(s):  
Growth Factor ◽  
Colon Carcinoma ◽  
Transforming Growth Factor ◽  
Human Colon ◽  
Transforming Growth Factor Β1 ◽  
Carcinoma Cells ◽  
Colon Carcinoma Cells ◽  
Human Colon Carcinoma
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