scholarly journals Isolation of Differentiated Squamous and Undifferentiated Spindle Carcinoma Cell Lines with Differing Metastatic Potential from a 4-Nitroquinoline N-Oxide-induced Tongue Carcinoma in a F344 Rat

2000 ◽  
Vol 91 (12) ◽  
pp. 1211-1221 ◽  
Author(s):  
Shinichi Takeuchi ◽  
Hayao Nakanishi ◽  
Kenji Yoshida ◽  
Shinji Yamamoto ◽  
Hidefumi Tonoki ◽  
...  
Keyword(s):  
Cell Lines ◽  
Carcinoma Cell ◽  
Metastatic Potential ◽  
Tongue Carcinoma ◽  
Carcinoma Cell Lines ◽  
F344 Rat

scholarly journals Metastatic Esophageal Carcinoma Cells Exhibit Reduced Adhesion Strength and Enhanced Thermogenesis

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1213
Author(s):  
Zihe Huo ◽  
Mariana Sá Santos ◽  
Astrid Drenckhan ◽  
Stefan Holland-Cunz ◽  
Jakob R. Izbicki ◽  
...  
Keyword(s):  
Esophageal Carcinoma ◽  
Tumor Cells ◽  
Cell Lines ◽  
Adhesion Strength ◽  
Primary Tumor ◽  
Carcinoma Cell ◽  
Metastatic Potential ◽  
Primary Tumors ◽  
Metastatic Cell ◽  
Carcinoma Cell Lines

Despite continuous improvements in multimodal therapeutic strategies, esophageal carcinoma maintains a high mortality rate. Metastases are a major life-limiting component; however, very little is known about why some tumors have high metastatic potential and others not. In this study, we investigated thermogenic activity and adhesion strength of primary tumor cells and corresponding metastatic cell lines derived from two patients with metastatic adenocarcinoma of the esophagus. We hypothesized that the increased metastatic potential of the metastatic cell lines correlates with higher thermogenic activity and decreased adhesion strength. Our data show that patient-derived metastatic esophageal tumor cells have a higher thermogenic profile as well as a decreased adhesion strength compared to their corresponding primary tumor cells. Using two paired esophageal carcinoma cell lines of primary tumor and lymph nodes makes the data unique. Both higher specific thermogenesis profile and decreased adhesion strength are associated with a higher metastatic potential. They are in congruence with the clinical patient presentation. Understanding these functional, biophysical properties of patient derived esophageal carcinoma cell lines will enable us to gain further insight into the mechanisms of metastatic potential of primary tumors and metastases. Microcalorimetric evaluation will furthermore allow for rapid assessment of new treatment options for primary tumor and metastases aimed at decreasing the metastatic potential.

scholarly journals Validation of reference genes for the normalization of RT-qPCR expression studies in human tongue carcinoma cell lines and tissue

2017 ◽  
Vol 13 (5) ◽  
pp. 3951-3957 ◽  
Author(s):  
Xiaofeng Wang ◽  
Xin Liu ◽  
Cong Liu ◽  
Ming Ren ◽  
Sujie Gao ◽  
...  
Keyword(s):  
Cell Lines ◽  
Reference Genes ◽  
Carcinoma Cell ◽  
Tongue Carcinoma ◽  
Carcinoma Cell Lines ◽  
Human Tongue ◽  
Expression Studies

Mammary carcinoma cell lines of high and low metastatic potential differ not in extravasation but in subsequent migration and growth

1994 ◽  
Vol 12 (6) ◽  
pp. 357-367 ◽  
Author(s):  
Vincent L. Morris ◽  
Sahadia Koop ◽  
Ian C. MacDonald ◽  
Eric E. Schmidt ◽  
Marsha Grattan ◽  
...  
Keyword(s):  
Cell Lines ◽  
Mammary Carcinoma ◽  
Carcinoma Cell ◽  
Metastatic Potential ◽  
Mammary Carcinoma Cell ◽  
Carcinoma Cell Lines

Comparative analysis of colorectal carcinoma cell lines that differ in metastatic potential

2013 ◽  
Vol 7 (5) ◽  
pp. 407-416
Author(s):  
A. P. Davydov-Sinitsyn ◽  
O. V. Bajenova ◽  
M. A. Liskovykh ◽  
S. V. Ponomartsev ◽  
L. L. Chechik ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Colorectal Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Metastatic Potential ◽  
Carcinoma Cell Lines
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