Functional characterization of muscarinic receptor subtypes in human duodenal secretion

2004 ◽  
Vol 182 (1) ◽  
pp. 63-68 ◽  
Author(s):  
R. Larsen ◽  
M. B. Hansen ◽  
N. Bindslev ◽  
A. Mertz-Nielsen
Keyword(s):  
Muscarinic Receptor ◽  
Functional Characterization ◽  
Receptor Subtypes ◽  
Muscarinic Receptor Subtypes

scholarly journals Functional Characterization of Muscarinic Receptors in Human Schwann Cells

2020 ◽  
Vol 21 (18) ◽  
pp. 6666
Author(s):  
Roberta Piovesana ◽  
Alessandro Faroni ◽  
Ada Maria Tata ◽  
Adam J. Reid
Keyword(s):  
Cell Proliferation ◽  
Schwann Cells ◽  
Muscarinic Receptor ◽  
Muscarinic Receptors ◽  
Functional Characterization ◽  
Receptor Subtypes ◽  
Muscarinic Receptor Subtypes ◽  
Selective Stimulation ◽  
Stimulation Of

Functional characterization of muscarinic cholinergic receptors in myelinating glial cells has been well described both in central and peripheral nervous system. Rat Schwann cells (SCs) express different muscarinic receptor subtypes with the prevalence of the M2 subtype. The selective stimulation of this receptor subtype inhibits SC proliferation, improving their differentiation towards myelinating phenotype. In this work, we describe for the first time that human SCs are cholinoceptive as they express several muscarinic receptor subtypes and, as for rat SCs, M2 receptor is one of the most abundant. Human SCs, isolated from adult nerves, were cultured in vitro and stimulated with M2 muscarinic agonist arecaidine propargyl ester (APE). Similarly to that observed in rat, M2 receptor activation causes a decreased cell proliferation and promotes SC differentiation as suggested by increased Egr2 expression with an improved spindle-like shape cell morphology. Conversely, the non-selective stimulation of muscarinic receptors appears to promote cell proliferation with a reduction of SC average cell diameter. The data obtained demonstrate that human SCs are cholinoceptive and that human cultured SCs may represent an interesting tool to understand their physiology and increase the knowledge on how the cholinergic stimulation may contribute to address human SC development in normal and pathological conditions.

scholarly journals Pharmacological and functional characterization of muscarinic receptor subtypes in developing oligodendrocytes

2001 ◽  
Vol 77 (5) ◽  
pp. 1396-1406 ◽  
Author(s):  
Fadi Ragheb ◽  
Eduardo Molina-Holgado ◽  
Qiao-Ling Cui ◽  
Amani Khorchid ◽  
Hsueh-Ning Liu ◽  
...  
Keyword(s):  
Muscarinic Receptor ◽  
Functional Characterization ◽  
Receptor Subtypes ◽  
Muscarinic Receptor Subtypes

In Vivo Characterization of Muscarinic Receptor Subtypes That Mediate Vasodilatation in Patients With Essential Hypertension

Hypertension ◽  
1995 ◽  
Vol 26 (1) ◽  
pp. 70-77 ◽  
Author(s):  
Tobias A. Bruning ◽  
Peter C. Chang ◽  
Maarten G.C. Hendriks ◽  
Pieter Vermeij ◽  
Martin Pfaffendorf ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Muscarinic Receptor ◽  
Receptor Subtypes ◽  
Muscarinic Receptor Subtypes ◽  
In Vivo Characterization

scholarly journals Characterization of muscarinic receptor subtypes in SO2-induced mucus hypersecretion in rat brochitis model

1999 ◽  
Vol 79 ◽  
pp. 37
Author(s):  
Ikuo Aoki ◽  
Junichi Eiki ◽  
Masahiko Kobayashi ◽  
Toshifumi Kimura ◽  
Toshiaki Mase ◽  
...  
Keyword(s):  
Muscarinic Receptor ◽  
Receptor Subtypes ◽  
Muscarinic Receptor Subtypes ◽  
Mucus Hypersecretion
Sign in / Sign up

Export Citation Format

Share Document