A polymorphic dinucleotide repeat microsatellite detected in the ovine interleukin 2 receptor alpha (ILZRA, CD25) gene

2009 ◽  
Vol 25 (3) ◽  
pp. 200-200 ◽  
Author(s):  
P Matthew ◽  
J F Maddox
Keyword(s):  
Interleukin 2 ◽  
Dinucleotide Repeat ◽  
Receptor Alpha ◽  
Interleukin 2 Receptor ◽  
Polymorphic Dinucleotide Repeat ◽  
Polymorphic Dinucleotide

Interleukin-2 receptor alpha-chain (CD25) expression on leukaemic blasts is predictive for outcome and level of residual disease in AML

2009 ◽  
Vol 45 (9) ◽  
pp. 1692-1699 ◽  
Author(s):  
Monique Terwijn ◽  
Nicole Feller ◽  
Anna van Rhenen ◽  
Angèle Kelder ◽  
Guus Westra ◽  
...  
Keyword(s):  
Residual Disease ◽  
Interleukin 2 ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Cd25 Expression ◽  
Interleukin 2 Receptor ◽  
Receptor Alpha Chain

scholarly journals Transcript synthesis and surface expression of the interleukin-2 receptor (alpha-, beta-, and gamma-chain) by normal and malignant myeloid cells

Blood ◽  
1996 ◽  
Vol 87 (6) ◽  
pp. 2419-2427 ◽  
Author(s):  
RR Schumann ◽  
T Nakarai ◽  
HJ Gruss ◽  
MA Brach ◽  
U von Arnim ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Tyrosine Phosphorylation ◽  
Interleukin 2 ◽  
Myeloid Cells ◽  
Janus Kinase ◽  
Myelogenous Leukemia ◽  
Common Finding ◽  
Receptor Alpha ◽  
Interleukin 2 Receptor ◽  
Alpha Beta

Expression of the interleukin-2 receptor alpha-(IL-2Ralpha-), IL-2Rbeta- , and the recently identified IL-2Rgamma-chain was examined on a wide range of cells of myeloid origin including neutrophils, monocytes, normal bone marrow-derived myeloid progenitors enriched for CD34+ cells, bone marrow blasts obtained from acute myelogenous leukemia (AML) patients, and permanent myeloid leukemia cell lines by reverse transcriptase-polymerase chain reaction and surface membrane analysis using receptor chain-specific monoclonal antibodies and flow cytometry. Expression of the p75 IL-2Rbeta- and the p64 IL-2Rgamma-chain was a common finding in most of the myeloid cell samples investigated, whereas IL-2Ralpha-chain was less frequently expressed. Although the high-affinity IL-2R form (ie, the alpha+, beta+, gamma+ IL-2R form) was detectable in a small minority of primary AML samples as well as the KG- 1 cell line and IL-2 binding to these cells was sufficient to initiate signal transduction as evidenced by an increase in overall protein tyrosine phosphorylation and more specifically in tyrosine phosphorylation of the Janus kinase (JAK) 3, in none of these cell types did exposure to IL-2 affect cell growth kinetics. These results suggest that, in myeloid cells, the IL-2R may not stimulate mitogenic responses or that its components may be expressed in a combinational association with receptors for other cytokines and that IL-2Rgamma may play a regulatory role in normal and malignant myelopoiesis possibly independent from IL-2. Because recent studies by others have indicated that the IL-2Rgamma- chain may be shared by the IL-4R, the IL-7R, and most likely the IL-9R, expression of mRNA of these receptor types was also investigated in these cell samples. Surprisingly, in a substantial part of the myeloid lineage cells examined, an IL-2Rgamma+, IL-4R-, IL7R- configuration was noted that was, however, frequently associated with expression of IL-9R. Sharing of IL-9R/IL-2R components was furthermore suggested by inhibition of 125I-IL-2 binding to primary AML cells with excess of unlabeled IL-9.

Analysis and Characterization of the Interleukin 2 Receptor alpha and beta Chain Expression inCD4-CD8- Cells

1990 ◽  
Vol 31 (4) ◽  
pp. 485-491
Author(s):  
J. C. GUTIERREZ-RAMOS ◽  
L. PEZZI ◽  
E. LEONARDO ◽  
C. MARTIN ◽  
C. MARTINEZ-A
Keyword(s):  
Interleukin 2 ◽  
Beta Chain ◽  
Cd8 Cells ◽  
Receptor Alpha ◽  
Interleukin 2 Receptor

scholarly journals A polymorphic dinucleotide repeat at the DXS7 locus

1992 ◽  
Vol 20 (4) ◽  
pp. 929-929 ◽  
Author(s):  
B.J. Moore ◽  
S.P. Kwan ◽  
N.T. Bech-Hansen
Keyword(s):  
Dinucleotide Repeat ◽  
Polymorphic Dinucleotide Repeat ◽  
Polymorphic Dinucleotide
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