scholarly journals Degarelix, a novel GnRH antagonist, causes minimal histamine release compared with cetrorelix, abarelix and ganirelix in an ex vivo model of human skin samples

2010 ◽  
Vol 70 (4) ◽  
pp. 580-587 ◽  
Author(s):  
Wolfgang Koechling ◽  
Rolf Hjortkjaer ◽  
László B. Tankó
Keyword(s):  
Histamine Release ◽  
Human Skin ◽  
Gnrh Antagonist ◽  
Ex Vivo ◽  
Ex Vivo Model ◽  
Skin Samples

scholarly journals 683 New ex-vivo model containing the 3 layers of the human skin and mimicking fibrosis in adipose tissue

2017 ◽  
Vol 137 (10) ◽  
pp. S310
Author(s):  
R. Fitoussi ◽  
G. Beauchef ◽  
P. Matarrese ◽  
K. Vié
Keyword(s):  
Adipose Tissue ◽  
Human Skin ◽  
Ex Vivo ◽  
Ex Vivo Model

scholarly journals Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model

Chemosphere ◽  
2016 ◽  
Vol 162 ◽  
pp. 308-314 ◽  
Author(s):  
Marie Frederiksen ◽  
Katrin Vorkamp ◽  
Niels Martin Jensen ◽  
Jens Ahm Sørensen ◽  
Lisbeth E. Knudsen ◽  
...  
Keyword(s):  
Human Skin ◽  
Flame Retardants ◽  
Ex Vivo ◽  
Percutaneous Penetration ◽  
Ex Vivo Model ◽  
Dermal Uptake

scholarly journals Impact of cigarette smoke on physical‐chemical and molecular proprieties of human skin in an ex vivo model

2020 ◽  
Author(s):  
Giuseppe Percoco ◽  
Angela Patatian ◽  
Florine Eudier ◽  
Michel Grisel ◽  
Thomas Bader ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Human Skin ◽  
Ex Vivo ◽  
Ex Vivo Model ◽  
Physical Chemical

scholarly journals Vitamin C–squalene bioconjugate promotes epidermal thickening and collagen production in human skin

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
R. Gref ◽  
C. Deloménie ◽  
A. Maksimenko ◽  
E. Gouadon ◽  
G. Percoco ◽  
...  
Keyword(s):  
Vitamin C ◽  
Human Skin ◽  
Ex Vivo ◽  
Ex Vivo Model ◽  
Collagen Formation ◽  
Skin Physiology ◽  
Collagen Iii ◽  
Skin Explants ◽  
Natural Lipid ◽  
Vit C

Abstract Vitamin C (Vit C) benefits to human skin physiology notably by stimulating the biosynthesis of collagen. The main cutaneous collagens are types I and III, which are less synthesized with aging. Vit C is one of the main promotors of collagen formation but it poorly bypasses the epidermis stratum corneum barrier. To address this challenge, we developed a lipophilic version of Vit C for improving skin diffusion and delivery. Vit C was covalently conjugated to squalene (SQ), a natural lipid of the skin, forming a novel Vit C–SQ derivative suitable for cream formulation. Its biological activity was investigated on human whole skin explants in an ex vivo model, through histology and protein and gene expression analyses. Results were compared to Vit C coupled to the reference lipophilic compound palmitic acid, (Vit C–Palmitate). It was observed that Vit C–SQ significantly increased epidermal thickness and preferentially favored collagen III production in human skin after application for 10 days. It also promoted glycosaminoglycans production in a higher extent comparatively to Vit C–Palmitate and free Vit C. Microdissection of the explants to separate dermis and epidermis allowed to measure higher transcriptional effects either in epidermis or in dermis. Among the formulations studied, the strongest effects were observed with Vit C–SQ.

Ex vivo model of human skin (hOSEC) for assessing the dermatokinetics of the anti-melanoma drug Dacarbazine

2021 ◽  
Vol 160 ◽  
pp. 105769
Author(s):  
Marcel Nani Leite ◽  
Juliana Santos Rosa Viegas ◽  
Fabíola Silva Garcia Praça ◽  
Natália Aparecida de Paula ◽  
Leandra Náira Zambelli Ramalho ◽  
...  
Keyword(s):  
Human Skin ◽  
Ex Vivo ◽  
Ex Vivo Model

scholarly journals Dermal uptake and percutaneous penetration of organophosphate esters in a human skin ex vivo model

Chemosphere ◽  
2018 ◽  
Vol 197 ◽  
pp. 185-192 ◽  
Author(s):  
Marie Frederiksen ◽  
Heather M. Stapleton ◽  
Katrin Vorkamp ◽  
Thomas F. Webster ◽  
Niels Martin Jensen ◽  
...  
Keyword(s):  
Human Skin ◽  
Ex Vivo ◽  
Percutaneous Penetration ◽  
Ex Vivo Model ◽  
Organophosphate Esters ◽  
Dermal Uptake

scholarly journals Ex vivo Model of Human Skin (hOSEC) as Alternative to Animal use for Cosmetic Tests

2015 ◽  
Vol 110 ◽  
pp. 67-73 ◽  
Author(s):  
T.A. Andrade ◽  
A.F. Aguiar ◽  
F.A. Guedes ◽  
M.N. Leite ◽  
G.F. Caetano ◽  
...  
Keyword(s):  
Human Skin ◽  
Ex Vivo ◽  
Ex Vivo Model ◽  
Animal Use
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