Selective expression and cellular localization of pro-inflammatory chemokine ligand/receptor pairs in the sciatic nerves of a severe murine experimental autoimmune neuritis model of Guillain-Barré syndrome

2010 ◽  
Vol 36 (5) ◽  
pp. 388-398 ◽  
Author(s):  
R. H. Xia ◽  
N. Yosef ◽  
E. E. Ubogu
Keyword(s):  
Cellular Localization ◽  
Guillain Barre Syndrome ◽  
Experimental Autoimmune Neuritis ◽  
Guillain Barré Syndrome ◽  
Selective Expression ◽  
Chemokine Ligand ◽  
Sciatic Nerves ◽  
Guillain Barré ◽  
Experimental Autoimmune

scholarly journals Beneficial or Harmful Role of Macrophages in Guillain-Barré Syndrome and Experimental Autoimmune Neuritis

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Donghui Shen ◽  
Fengna Chu ◽  
Yue Lang ◽  
Yunlong Geng ◽  
Xiangyu Zheng ◽  
...  
Keyword(s):  
Macrophage Polarization ◽  
Critical Role ◽  
Decisive Role ◽  
Guillain Barre Syndrome ◽  
Experimental Autoimmune Neuritis ◽  
Guillain Barré Syndrome ◽  
Anti Inflammatory ◽  
Autoimmune Demyelination ◽  
Guillain Barré ◽  
Experimental Autoimmune

Guillain-Barré syndrome (GBS), an immune-mediated demyelinating peripheral neuropathy, is characterized by acute weakness of the extremities and areflexia or hyporeflexia. Experimental autoimmune neuritis (EAN) is a common animal model for GBS, which represents a CD4+ T cell-mediated inflammatory autoimmune demyelination of the peripheral nervous system (PNS), and is used to investigate the pathogenic mechanism of GBS. It has been found that macrophages play a critical role in the pathogenesis of both GBS and EAN. Macrophages have been primarily classified into two major phenotypes: proinflammatory macrophages (M1) and anti-inflammatory macrophages (M2). The two different macrophage subsets M1 and M2 may play a decisive role in initiation and development of GBS and EAN. However, recently, it has been indicated that the roles of macrophages in immune regulation and autoimmune diseases are more complex than those suggested by a simple M1-M2 dichotomy. Macrophages might exert either inflammatory or anti-inflammatory effect by secreting pro- or anti-inflammatory cytokines, and either inducing the activation of T cells to mediate immune response, resulting in inflammation and demyelination in the PNS, or promoting disease recovery. In this review, we summarize the dual roles of macrophages in GBS and EAN and explore the mechanism of macrophage polarization to provide a potential therapeutic approach for GBS in the future.

scholarly journals The Role of Apolipoprotein E in Guillain-Barré Syndrome and Experimental Autoimmune Neuritis

2010 ◽  
Vol 2010 ◽  
pp. 1-12 ◽  
Author(s):  
Hong-liang Zhang ◽  
Jiang Wu ◽  
Jie Zhu
Keyword(s):  
Apolipoprotein E ◽  
Guillain Barre Syndrome ◽  
Special Focus ◽  
Experimental Autoimmune Neuritis ◽  
Specific Effects ◽  
Guillain Barré Syndrome ◽  
Lipid Antigen ◽  
Guillain Barré ◽  
Experimental Autoimmune

Apolipoprotein E (apoE) is a 34.2 kDa glycosylated protein characterized by its wide tissue distribution and multiple functions. ApoE has been widely studied in lipid metabolism, cardiocerebrovascular diseases, and neurodegenerative diseases like Alzheimer's disease and mild cognitive impairment, and so forth. Recently, a growing body of evidence has pointed to nonlipid related properties of apoE, including suppression of T cell proliferation, regulation of macrophage function, facilitation of lipid antigen presentation by CD1 molecules to natural killer T (NKT) cells, and modulation of inflammation and oxidation. By these properties, apoE impacts physiology and pathophysiology at multiple levels. The present paper summarizes updated studies on the immunoregulatory function of apoE, with special focus on isoform-specific effects of apoE on Guillain-Barré syndrome (GBS) and its animal model experimental autoimmune neuritis (EAN).

scholarly journals CCR2 Gene Deletion and Pharmacologic Blockade Ameliorate a Severe Murine Experimental Autoimmune Neuritis Model of Guillain-Barré Syndrome

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e90463 ◽  
Author(s):  
Furong Yuan ◽  
Nejla Yosef ◽  
Chetan Lakshmana Reddy ◽  
Ailing Huang ◽  
Sharon C. Chiang ◽  
...  
Keyword(s):  
Gene Deletion ◽  
Guillain Barre Syndrome ◽  
Experimental Autoimmune Neuritis ◽  
Ccr2 Gene ◽  
Guillain Barré Syndrome ◽  
Guillain Barré ◽  
Experimental Autoimmune

Guillain–Barré syndrome serum and anti-Campylobacter antibody do not exacerbate experimental autoimmune neuritis

2001 ◽  
Vol 119 (2) ◽  
pp. 306-316 ◽  
Author(s):  
Robert D.M Hadden ◽  
Norman A Gregson ◽  
Ralf Gold ◽  
Hugh J Willison ◽  
Richard A.C Hughes
Keyword(s):  
Guillain Barre Syndrome ◽  
Experimental Autoimmune Neuritis ◽  
Guillain Barré Syndrome ◽  
Guillain Barré ◽  
Experimental Autoimmune
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