Effect of a triple blockade of the renin-angiotensin-system in recurrent focal segmental glomerulosclerosis after kidney transplantation

2009 ◽  
Vol 22 (11) ◽  
pp. 1110-1113 ◽  
Author(s):  
Verena Freiberger ◽  
Kerstin Amann ◽  
Uwe Heemann ◽  
Helga Frank
Keyword(s):  
Kidney Transplantation ◽  
Focal Segmental Glomerulosclerosis ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Segmental Glomerulosclerosis

scholarly journals Genetic polymorphisms of the renin-angiotensin system and the outcome of focal segmental glomerulosclerosis in children

1998 ◽  
Vol 54 (6) ◽  
pp. 1843-1849 ◽  
Author(s):  
Yaacov Frishberg ◽  
Rachel Becker-Cohen ◽  
David Halle ◽  
Elad Feigin ◽  
Bella Eisenstein ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Focal Segmental Glomerulosclerosis ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Segmental Glomerulosclerosis

Renin Angiotensin System Blockade in Kidney Transplantation: A Systematic Review of the Evidence

2007 ◽  
Vol 7 (10) ◽  
pp. 2350-2360 ◽  
Author(s):  
S. Hiremath ◽  
D. Fergusson ◽  
S. Doucette ◽  
A. V. Mulay ◽  
G. A. Knoll
Keyword(s):  
Systematic Review ◽  
Kidney Transplantation ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

scholarly journals Renin–angiotensin system blockade and kidney transplantation: a longitudinal cohort study

2011 ◽  
Vol 27 (1) ◽  
pp. 417-422 ◽  
Author(s):  
Domingo Hernández ◽  
Alfonso Muriel ◽  
Víctor Abraira ◽  
Germán Pérez ◽  
Esteban Porrini ◽  
...  
Keyword(s):  
Cohort Study ◽  
Kidney Transplantation ◽  
Renin Angiotensin System ◽  
Longitudinal Cohort Study ◽  
Angiotensin System ◽  
Longitudinal Cohort ◽  
Renin Angiotensin

scholarly journals Molecular remodeling of the renin-angiotensin system after kidney transplantation

2017 ◽  
Vol 18 (2) ◽  
pp. 147032031770523 ◽  
Author(s):  
Marlies Antlanger ◽  
Oliver Domenig ◽  
Johannes J Kovarik ◽  
Christopher C Kaltenecker ◽  
Chantal Kopecky ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Graft Function ◽  
Renin Angiotensin System ◽  
Substantial Improvement ◽  
Individual Variability ◽  
Ang Ii ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Plasma Angiotensin

Objective: We aimed at assessing the molecular adaptation of the renin-angiotensin system (RAS) after successful kidney transplantation (KTX). Materials and methods: In this prospective, exploratory study we analyzed 12 hemodialysis (HD) patients, who received a KTX and had excellent graft function six to 12 months thereafter. The concentrations of plasma Angiotensin (Ang) peptides (Ang I, Ang II, Ang-(1–7), Ang-(1–5), Ang-(2–8), Ang-(3–8)) were simultaneously quantified with a novel mass spectrometry-based method. Further, renin and aldosterone concentrations were determined by standard immunoassays. Results: Ang values showed a strong inter-individual variability among HD patients. Yet, despite a continued broad dispersion of Ang values after KTX, a substantial improvement of the renin/Ang II correlation was observed in patients without RAS blockade or on angiotensin receptor blocker (HD: renin/Ang II R2 = 0.660, KTX: renin/Ang II R2 = 0.918). Ang-(1–7) representing the alternative RAS axis was only marginally detectable both on HD and after KTX. Conclusions: Following KTX, renin-dependent Ang II formation adapts in non-ACE inhibitor-treated patients. Thus, a largely normal RAS regulation is reconstituted after successful KTX. However, individual Ang concentration variations and a lack of potentially beneficial alternative peptides after KTX call for individualized treatment. The long-term post-transplant RAS regulation remains to be determined.

scholarly journals Intrarenal Renin-Angiotensin-System Dysregulation after Kidney Transplantation

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Johannes J. Kovarik ◽  
Christopher C. Kaltenecker ◽  
Chantal Kopecky ◽  
Oliver Domenig ◽  
Marlies Antlanger ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin
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