Thrombolysis in Cervical Artery Dissection - Data from the Cervical Artery Dissection and Ischaemic Stroke Patients (CADISP) database

2012 ◽  
Vol 19 (9) ◽  
pp. 1199-1206 ◽  
Author(s):  
S. T. Engelter ◽  
J. Dallongeville ◽  
M. Kloss ◽  
T. M. Metso ◽  
D. Leys ◽  
...  
Neurology ◽  
2012 ◽  
Vol 78 (16) ◽  
pp. 1221-1228 ◽  
Author(s):  
T. M. Metso ◽  
T. Tatlisumak ◽  
S. Debette ◽  
J. Dallongeville ◽  
S. T. Engelter ◽  
...  

2020 ◽  
pp. 221-262
Author(s):  
Charlotte Frise ◽  
Sally Collins

This chapter considers the effects of neurological conditions in the pregnant patient. This includes epilepsy, the use of antiepileptic drugs and any contraindications and problems for the fetus, and the management of seizures both pre- and postnatally. Ischaemic stroke, intracranial and subarachnoid haemorrhage, cervical artery dissection, moyamoya, headaches, migraine, and neonatal effects of myasthenia gravis are all discussed, along with management strategies. Inherited and acquired neuropathies are also covered, along with other neurological conditions.


2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Annette Fromm ◽  
Ulrike Waje-Andreassen ◽  
Lars Thomassen ◽  
Halvor Naess

Introduction. Young adults are likely to differ from old patients concerning cerebral infarction.Methods. We compared characteristics of patients aged under and above 50 years, admitted to the Department of Neurology with cerebral infarction between 2006 and 2009, based on prospective registration. Investigation followed one common protocol for both groups.Results and Discussion. One hundred patients (8.2%) were <50 years old, and the proportion of males was higher in this group (72% versus 55.8%, ). Young stroke patients are more often current smokers (44.1% versus 23.6%, ). Common causes for stroke in the young were cervical artery dissection (18% versus 0.6%, ) and cardiac embolism due to disorders other than atrial arrhythmias (18% versus 5.5%, ). Among the old, atrial fibrillation and flutter dominated (29.1% versus 5%, ). Stroke severity and location did not differ. Old patients more often suffered from pneumonia (10.6% versus 2%, ) and urinary tract infection (14.6% versus 2%, ).Conclusions. Males dominate, and current smoking is more common in the young. Cervical artery dissection and nonarrhythmic heart disorders are frequent causes among young patients, while traditional risk factors dominate the old. Stroke severity is similar, but old patients seem more exposed for infectious complications.


2015 ◽  
Vol 30 (6) ◽  
pp. 331-338 ◽  
Author(s):  
M. Almendrote ◽  
M. Millán ◽  
L.A. Prats ◽  
N. Pérez de la Ossa ◽  
E. López-Cancio ◽  
...  

2016 ◽  
Vol 42 (3-4) ◽  
pp. 272-279 ◽  
Author(s):  
Jueying Lin ◽  
Yefei Sun ◽  
Shanshan Zhao ◽  
Junjie Xu ◽  
Chuansheng Zhao

Background: Although thrombolysis is considered to be the first-line treatment for ischemic stroke, there remains an ongoing controversy on the safety and efficacy of thrombolysis in cervical artery dissection (CAD). The aim of this meta-analysis was to assess observational data related to the safety and efficacy of thrombolysis in CAD-related ischemic stroke. Methods: We performed a systematic search of the efficacy of thrombolysis treatment in CAD-related ischemic stroke with appropriate observational studies identified for the study. The meta-analysis models in Comprehensive Meta-Analysis V2 software were applied to calculate the merged rates of favorable outcome (modified Rankin Scale, mRS 0-2), excellent outcome (mRS 0-1), intracranial hemorrhage (ICH), symptomatic ICH (SICH), mortality and recurrent stroke between thrombolysis and non-thrombolysis in CAD-related stroke. The difference of outcomes and adverse events between the 2 groups was compared by analyzing the pooled OR value and chi-square test using the software SPSS. Results: A total of 846 patients were identified from 10 studies (174 with thrombolysis; 672 with non-thrombolysis). The meta-analysis detected no significant statistical difference in the proportion of CAD-related stroke patients enjoying a favorable outcome at the 3 months' follow-up between the thrombolysis and non-thrombolysis groups (53.7 vs. 58.2%, OR 0.782, χ2 = 0.594, p > 0.05); non-thrombolysis was slightly superior than thrombolysis in terms of excellent outcome (52.4 vs. 34.4%, OR 0.489, χ2 = 9.143, p = 0.002). There was no significant difference in SICH, mortality and recurrent stroke rates between the 2 groups (all p > 0.05). ICH rate was higher in the thrombolysis group of CAD-related stroke patients compared to that in the non-thrombolysis group (12.3 vs. 7.4%, OR 2.647, χ2 = 4.127, p = 0.042). Conclusion: Thrombolysis seems to be equally safe and will achieve an efficacy similar to the efficacy of non-thrombolysis in patients with acute ischemic stroke due to CAD. It is also as effective as thrombolysis in stroke from miscellaneous causes. Therefore, CAD patients experiencing a stroke should not be denied thrombolysis therapy. However, this will need to be confirmed in large-scale randomized studies, especially involving intravenous thrombolysis treatment.


2019 ◽  
Vol 34 (3) ◽  
pp. 153-158
Author(s):  
L.A. Crespo Araico ◽  
R. Vera Lechuga ◽  
A. Cruz-Culebras ◽  
C. Matute Lozano ◽  
A. de Felipe Mimbrera ◽  
...  

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