Optimal Electrogram Voltage Recording Technique for Detecting the Acute Ablative Tissue Injury in the Human Right Atrium

2007 ◽  
Vol 18 (6) ◽  
pp. 617-622 ◽  
Author(s):  
YENN-JIANG LIN ◽  
CHING-TAI TAI ◽  
LI-WEI LO ◽  
AMEYA R. UDYAVAR ◽  
SHIH-LIN CHANG ◽  
...  
Keyword(s):  
Right Atrium ◽  
Tissue Injury ◽  
Human Right ◽  
Recording Technique ◽  
Human Right Atrium ◽  
Electrogram Voltage

A 5-HT4-like receptor in human right atrium

1991 ◽  
Vol 344 (2) ◽  
pp. 150-159 ◽  
Author(s):  
Alberto J. Kaumann ◽  
Louise Sanders ◽  
Anthony M. Brown ◽  
Kenneth J. Murray ◽  
Morris J. Brown
Keyword(s):  
Right Atrium ◽  
Human Right ◽  
Human Right Atrium

scholarly journals Urotensin II receptor expression in human right atrium and aorta: effects of ischaemic heart disease

2009 ◽  
Vol 102 (4) ◽  
pp. 477-484 ◽  
Author(s):  
A.D. Leonard ◽  
J.P. Thompson ◽  
E.L. Hutchinson ◽  
S.P. Young ◽  
J. McDonald ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischaemic Heart Disease ◽  
Right Atrium ◽  
Receptor Expression ◽  
Urotensin Ii ◽  
Human Right ◽  
Human Right Atrium

From cellular automata model of vagal control of the human right atrium to heart beats patterns

2021 ◽  
Vol 415 ◽  
pp. 132771
Author(s):  
Danuta Makowiec ◽  
Wiesław Miklaszewski ◽  
Joanna Wdowczyk ◽  
Anna T. Lawniczak
Keyword(s):  
Cellular Automata ◽  
Right Atrium ◽  
Human Right ◽  
Cellular Automata Model ◽  
Vagal Control ◽  
Human Right Atrium

scholarly journals Prostacyclins have no direct inotropic effect on isolated atrial strips from the normal and pressure-overloaded human right heart

2017 ◽  
Vol 7 (2) ◽  
pp. 339-347 ◽  
Author(s):  
Sarah Holmboe ◽  
Asger Andersen ◽  
Rebekka V. Jensen ◽  
Hans Henrik Kimose ◽  
Lars B. Ilkjær ◽  
...  
Keyword(s):  
Right Atrium ◽  
Quantitative Polymerase Chain Reaction ◽  
Organ Bath ◽  
Inotropic Response ◽  
Force Of Contraction ◽  
Human Right ◽  
Prostanoid Receptors ◽  
Right Heart ◽  
Inotropic Effects ◽  
Human Right Atrium

Prostacyclins are vasodilatory agents used in the treatment of pulmonary arterial hypertension. The direct effects of prostacyclins on right heart function are still not clarified. The aim of this study was to investigate the possible direct inotropic properties of clinical available prostacyclin mimetics in the normal and the pressure-overloaded human right atrium. Trabeculae from the right atrium were collected during surgery from chronic thromboembolic pulmonary hypertension (CTEPH) patients with pressure-overloaded right hearts, undergoing pulmonary thromboendarterectomy (n = 10) and from patients with normal right hearts operated by valve replacement or coronary bypass surgery (n = 9). The trabeculae were placed in an organ bath, continuously paced at 1 Hz. They were subjected to increasing concentrations of iloprost, treprostinil, epoprostenol, or MRE-269, followed by isoprenaline to elicit a reference inotropic response. The force of contraction was measured continuously. The expression of prostanoid receptors was explored through quantitative polymerase chain reaction (qPCR). Iloprost, treprostinil, epoprostenol, or MRE-269 did not alter force of contraction in any of the trabeculae. Isoprenaline showed a direct inotropic response in both trabeculae from the pressure-overloaded right atrium and from the normal right atrium. Control experiments on ventricular trabeculae from the pig failed to show an inotropic response to the prostacyclin mimetics. qPCR demonstrated varying expression of the different prostanoid receptors in the human atrium. In conclusion, prostacyclin mimetics did not increase the force of contraction of human atrial trabeculae from the normal or the pressure-overloaded right heart. These data suggest that prostacyclin mimetics have no direct inotropic effects in the human right atrium.

Dopaminergic and α-Adrenergic Control of Neurotransmission in Human Right Atrium

1995 ◽  
Vol 26 (3) ◽  
pp. 462-470 ◽  
Author(s):  
L. C. Rump ◽  
G. Riera-Knorrenschild ◽  
E. Schwertfeger ◽  
C. Bohmann ◽  
G. Spillner ◽  
...  
Keyword(s):  
Right Atrium ◽  
Human Right ◽  
Human Right Atrium ◽  
Adrenergic Control

Age-dependent decrease in the negative inotropic effect of carbachol on isolated human right atrium

1998 ◽  
Vol 357 (2-3) ◽  
pp. 199-202 ◽  
Author(s):  
Christine Giessler ◽  
Thekla Wangemann ◽  
Hans-Reinhard Zerkowski ◽  
Otto-Erich Brodde
Keyword(s):  
Right Atrium ◽  
Negative Inotropic Effect ◽  
Inotropic Effect ◽  
Human Right ◽  
Age Dependent ◽  
Human Right Atrium

scholarly journals Simultaneous Endo‐Epicardial Mapping of the Human Right Atrium: Unraveling Atrial Excitation

2020 ◽  
Vol 9 (17) ◽  
Author(s):  
Rohit K. Kharbanda ◽  
Paul Knops ◽  
Lisette J. M. E. van der Does ◽  
Charles Kik ◽  
Yannick J. H. J. Taverne ◽  
...  
Keyword(s):  
Sinus Rhythm ◽  
Right Atrium ◽  
Conduction Block ◽  
Significant Degree ◽  
Interquartile Range ◽  
Human Right ◽  
3 Dimensional ◽  
Conduction Disorders ◽  
Human Right Atrium ◽  
History Of

Background The significance of endo‐epicardial asynchrony (EEA) and atrial conduction block (CB), which play an important role in the pathophysiology of atrial fibrillation (AF) during sinus rhythm is poorly understood. The aim of our study was therefore to examine 3‐dimensional activation of the human right atrium (RA). Methods and Results Eighty patients (79% men, 39% history of AF) underwent simultaneous endo‐epicardial sinus rhythm mapping of the inferior, middle and superior RA. Areas of CB were defined as conduction delays of ≥12 ms, EEA as activation time differences of opposite electrodes of ≥15 ms and transmural CB as CB at similar endo‐epicardial sites. CB was more pronounced at the endocardium (all locations P <0.025). Amount, extensiveness and severity of CB was higher at the superior RA. Transmural CB at the inferior RA was associated with a higher incidence of post‐operative AF ( P =0.03). EEA occurred up to 84 ms and was more pronounced at the superior RA (superior: 27 ms [interquartile range, 18.3–39.3], versus mid‐RA: 20.3 ms [interquartile range, 0–29.9], and inferior RA: 0 ms [interquartile range, 0–21], P <0.001). Hypertension ( P =0.009), diabetes mellitus ( P =0.018), and hypercholesterolemia ( P =0.015) were associated with a higher degree of EEA. CB ( P =0.007) and EEA ( P =0.037) were more pronounced in patients with a history of persistent AF compared with patients without AF history. Conclusions This study provides important insights into complex atrial endo‐epicardial excitation. Significant differences in conduction disorders between the endo‐ and epicardium and a significant degree of EEA are already present during sinus rhythm and are more pronounced in patients with cardiovascular risk factors or a history of persistent AF.

Sign in / Sign up

Export Citation Format

Share Document