Growth Hormone, Skin and Wound Healing-experimental studies in the rat

Apmis ◽  
1997 ◽  
Vol 105 (S72) ◽  
pp. 5-54 ◽  
Author(s):  
PETER HOLMBERG JØRGENSEN
Keyword(s):  
Growth Hormone ◽  
Wound Healing ◽  
Experimental Studies

scholarly journals Chronic limb-threatening ischemia could benefit from growth hormone therapy for wound healing and limb salvage

2017 ◽  
Vol 12 (2) ◽  
pp. 53-72 ◽  
Author(s):  
Diego Caicedo ◽  
Pablo Devesa ◽  
Víctor M. Arce ◽  
Julia Requena ◽  
Jesús Devesa
Keyword(s):  
Growth Hormone ◽  
Wound Healing ◽  
Growth Hormone Therapy ◽  
Experimental Studies ◽  
Redox Balance ◽  
Cardiovascular Complications ◽  
Limb Amputation ◽  
Diabetic Patients ◽  
Peripheral Arteries ◽  
Pros And Cons

Revascularization for chronic limb-threatening ischemia (CLTI) is necessary to alleviate symptoms and wound healing. When it fails or is not possible, there are few alternatives to avoid limb amputation in these patients. Although experimental studies with stem cells and growth factors have shown promise, clinical trials have demonstrated inconsistent results because CLTI patients generally need arteriogenesis rather than angiogenesis. Moreover, in addition to the perfusion of the limb, there is the need to improve the neuropathic response for wound healing, especially in diabetic patients. Growth hormone (GH) is a pleiotropic hormone capable of boosting the aforementioned processes and adds special benefits for the redox balance. This hormone has the potential to mitigate symptoms in ischemic patients with no other options and improves the cardiovascular complications associated with the disease. Here, we discuss the pros and cons of using GH in such patients, focus on its effects on peripheral arteries, and analyze the possible benefits of treating CLTI with this hormone.

Collagen from Marine Sources and Skin Wound Healing in Animal Experimental Studies: a Systematic Review

2021 ◽  
Author(s):  
Matheus Almeida Cruz ◽  
Tiago Akira Araujo ◽  
Ingrid Regina Avanzi ◽  
Julia Risso Parisi ◽  
Ana Laura Martins de Andrade ◽  
...  
Keyword(s):  
Systematic Review ◽  
Wound Healing ◽  
Experimental Studies ◽  
Skin Wound ◽  
Skin Wound Healing

The Effect of Plantago major on Wound Healing in Preclinical Studies: A Systematic Review

2021 ◽  
Vol 67 (1) ◽  
pp. 27-34
Author(s):  
Fernanda Cardoso ◽  
Jéssica Breder ◽  
Priscila Apolinário ◽  
Henrique Oliveia ◽  
Maria Saidel ◽  
...  
Keyword(s):  
Systematic Review ◽  
Wound Healing ◽  
Meta Analysis ◽  
Experimental Studies ◽  
Risk Of Bias ◽  
Preclinical Studies ◽  
Plantago Major ◽  
Best Response ◽  
Meta Analyses

BACKGROUND: Plantago major is a medicinal plant that has been used for centuries to treat various health conditions including wounds. PURPOSE: To investigate the effectiveness of the topical use of P major in healing skin wounds in animal models. METHODS: Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic review was conducted. Seven (7) electronic databases (Virtual Health Library, Public/Publisher MEDLINE, Scopus, Web of Science, Embase, Cumulative Index of Nursing and Allied Health Literature, and CAB Direct) were searched for controlled studies published in English from January 2006 to March 2020. The Collaborative Approach to Meta Analysis and Review of Animal Data from Experimental Studies tools guided the evaluation of the studies and determined their quality. The Systematic Review Center for Laboratory Animal Experimentation was used to assess the risk of bias. RESULTS: Of the 176 publications identified, 4 met the inclusion criteria. Studies included 20 to 100 animals and varying concentrations of P major. There were no reports of losses during research. Wound healing was assessed between 17 and 21 days following wounding. The best response in terms of wound contraction rate occurred with 10%, 20%, and 50% concentrations when compared with control groups. One (1) study did not have an animal ethics committee review. All studies had a high risk of bias and a lack of methodological rigor. CONCLUSION: The results of this review did not find evidence about the in vivo effectiveness of P major for wound healing. More rigorous preclinical studies with adequate sample sizes are required to identify the best concentrations and formulations as well as increase understanding about the mechanisms of action of P major in wound healing.

scholarly journals Sex Hormones, Growth Hormone, and the Cornea

Cells ◽  
2022 ◽  
Vol 11 (2) ◽  
pp. 224
Author(s):  
Tina B. McKay ◽  
Shrestha Priyadarsini ◽  
Dimitrios Karamichos
Keyword(s):  
Growth Hormone ◽  
Wound Healing ◽  
Sex Hormones ◽  
Human Growth ◽  
The Body ◽  
Dependent Manner ◽  
Insulin Growth Factor ◽  
Epithelial Regeneration ◽  
Health And Disease ◽  
Interest Differential

The growth and maintenance of nearly every tissue in the body is influenced by systemic hormones during embryonic development through puberty and into adulthood. Of the ~130 different hormones expressed in the human body, steroid hormones and peptide hormones are highly abundant in circulation and are known to regulate anabolic processes and wound healing in a tissue-dependent manner. Of interest, differential levels of sex hormones have been associated with ocular pathologies, including dry eye disease and keratoconus. In this review, we discuss key studies that have revealed a role for androgens and estrogens in the cornea with focus on ocular surface homeostasis, wound healing, and stromal thickness. We also review studies of human growth hormone and insulin growth factor-1 in influencing ocular growth and epithelial regeneration. While it is unclear if endogenous hormones contribute to differential corneal wound healing in common animal models, the abundance of evidence suggests that systemic hormone levels, as a function of age, should be considered as an experimental variable in studies of corneal health and disease.

Growth hormone improved wound healing in rats using thermal injury as a model of trauma

Nutrition ◽  
1996 ◽  
Vol 12 (7-8) ◽  
pp. 576
Author(s):  
Michael J. Muller ◽  
Maureen A. Hollyoak ◽  
David N. Herndon
Keyword(s):  
Growth Hormone ◽  
Wound Healing ◽  
Thermal Injury

scholarly journals Local Growth Hormone Therapy for Pressure Ulcer Healing on a Human Skin Mouse Model

2019 ◽  
Vol 20 (17) ◽  
pp. 4157 ◽  
Author(s):  
Lara Cristóbal ◽  
Nerea de los Reyes ◽  
Miguel A. Ortega ◽  
Melchor Álvarez-Mon ◽  
Natalio García-Honduvilla ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Wound Healing ◽  
Mouse Model ◽  
Human Skin ◽  
Pressure Ulcer ◽  
Healing Rate ◽  
Recombinant Human Growth Hormone ◽  
Control Group ◽  
P Value ◽  
Type I

The growth hormone is involved in skin homeostasis and wound healing. We hypothesize whether it is possible to improve pressure ulcer (PU) healing by locally applying the recombinant human growth hormone (rhGH) in a human skin mouse model. Non-obese diabetic/severe combined immunodeficient mice (n = 10) were engrafted with a full-thickness human skin graft. After 60 days with stable grafts, human skin underwent three cycles of ischemia-reperfusion with a compression device to create a PU. Mice were classified into two groups: rhGH treatment group (n = 5) and control group (n = 5). In the rhGH group for local intradermal injections, each had 0.15 mg (0.5IU) applied to the PU edges, once per week for four weeks. Evaluation of the wound healing was conducted with photographic and visual assessments, and histological analysis was performed after complete wound healing. The results showed a healing rate twice as fast in the rhGH group compared to the control group (1.25 ± 0.33 mm2/day versus 0.61 ± 0.27 mm2/day; p-value < 0.05), with a faster healing rate during the first 30 days. The rhGH group showed thicker skin (1953 ± 457 µm versus 1060 ± 208 µm; p-value < 0.05) in the repaired area, with a significant decrease in collagen type I/III ratio at wound closure (62 days, range 60–70). Local administration of the rhGH accelerates PU healing in our model. The rhGH may have a clinical use in pressure ulcer treatment.

scholarly journals An Old Drug for a New Application: Potential Benefits of Sildenafil in Wound Healing

2012 ◽  
Vol 15 (4) ◽  
pp. 483 ◽  
Author(s):  
Shadi Farsaie ◽  
Hossein Khalili ◽  
Iman Karimzadeh ◽  
Simin Dashti-Khavidaki
Keyword(s):  
Wound Healing ◽  
Animal Studies ◽  
Case Reports ◽  
Experimental Studies ◽  
Phosphodiesterase Inhibitor ◽  
Cochrane Central Register ◽  
Skin Damage ◽  
Beneficial Effects ◽  
Cochrane Database ◽  
The Impact

Purpose: Several studies have evaluated the effects of sildenafil on the tissue repair and wound healing. In the present review, the impact of sildenafil on the wound healing in all available clinical and non-clinical (experimental) studies has been discussed. Methods: A literature search was performed using PubMed, Scopus, Medline, Embase, Cochrane central register of controlled trials and Cochrane database systematic reviews. Related articles indexed in Google Scholar were also included. Key words used as search terms were ‘phosphodiesterase inhibitor’, ‘sildenafil’, ‘skin’, ‘cutaneous’, ‘skin lesion’, ‘skin damage’, ‘wound’, and ‘wound healing’. No time limitation was considered in this review. Results: A total of 15 animal studies, 7 case reports, and 2 small clinical studies have reported the effects of sildenafil on the wound healing. The effects included skin flaps and grafts, anastomosis, systemic sclerosis and Raynaud's disease. Conclusions: The available data support the beneficial effects of sildenafil in improvement of tissue healing in various conditions. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

scholarly journals Experimental studies on the influence of endocrine glands on wound care

1934 ◽  
Vol 30 (7-8) ◽  
pp. 787-787
Author(s):  
H. J. Lauber
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Experimental Studies ◽  
Endocrine Glands ◽  
Rapid Improvement

The author was convinced that it is the influence of hormones, not the action of proteins, that is important in wound healing. A rich supply of hormones leads to a rapid improvement in metabolism, and the latter promotes rapid wound healing.

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