Immunohistochemical localization of bone morphogenetic protein (BMP) in calcifying fibrous epulis

1993 ◽  
Vol 22 (9) ◽  
pp. 406-410 ◽  
Author(s):  
Yang Lianjia ◽  
Jin Yan ◽  
Tatsuko Doi ◽  
Ichiro Sekine ◽  
Kazuhiro Ogawa ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Immunohistochemical Localization ◽  
Morphogenetic Protein

Immunohistochemical Localization of Bone Morphogenetic Protein-signaling Smads during Long-bone Distraction Osteogenesis

2006 ◽  
Vol 54 (4) ◽  
pp. 407-415 ◽  
Author(s):  
Tasima Haque ◽  
Manuela Mandu-Hrit ◽  
Frank Rauch ◽  
Dominique Lauzier ◽  
Maryam Tabrizian ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Expression Pattern ◽  
Distraction Osteogenesis ◽  
Immunohistochemical Localization ◽  
Bmp Signaling ◽  
Long Bone ◽  
Morphogenetic Protein ◽  
Smad Proteins ◽  
Consolidation Phase ◽  
The Right

In this study we investigated the expression of bone morphogenetic protein (BMP)-signaling Smads in distraction osteogenesis (DO). Osteotomy of the right tibia was performed in 14 skeletally mature white New Zealand male rabbits. Lengthening was started 1 week later at a rate of 0.5 mm/12 hr and was maintained for 3 weeks. Expression of Smad proteins 1, 4, 5, 6, 7, and 8 and Smad ubiquitin regulatory factors (Smurfs) 1 and 2 was evaluated in the distracted zone using immunohistochemistry. Expression of receptor-regulated Smads (R-Smads) 1, 5, and 8 showed a significant increase during the distraction phase, followed by a gradual decrease during the consolidation phase. Smad 4 showed significant expression during both distraction and the beginning of the consolidation phase. Smad 6 and Smad 7 were highly expressed during the consolidation phase. Staining for both Smurfs 1 and 2 was maximal at the end of the distraction period. Staining for all proteins was most intense in chondrocyte and fibroblast-like cells. Expression pattern of R-Smads correlated with our previously reported expression pattern of BMPs 2, 4, and 7 and their receptors. These results therefore suggest a role for the whole BMP signaling pathway including the Smad proteins in DO.

Expression, signalling and potential in vivo functions of Bone Morphogenetic Protein (BMP)-9 in the liver

2009 ◽  
Vol 47 (01) ◽  
Author(s):  
K Breitkopf ◽  
A Müller ◽  
L Ciuclan ◽  
E Wiercinska ◽  
P ten Dijke ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Morphogenetic Protein
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