ACTIVATION OF NF-KB IN HUMAN SKIN FIBROBLASTS BY THE OXIDATIVE STRESS GENERATED BY UVA RADIATION

1995 ◽  
Vol 62 (3) ◽  
pp. 463-468 ◽  
Author(s):  
Glenn F. Vile ◽  
Adrian Tanew-Iliitschew ◽  
Rex M. Tyrrell
Keyword(s):  
Oxidative Stress ◽  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Uva Radiation

Silver ions induce oxidative stress and intracellular zinc release in human skin fibroblasts

2009 ◽  
Vol 47 (11) ◽  
pp. 1570-1577 ◽  
Author(s):  
Miriam M. Cortese-Krott ◽  
Meike Münchow ◽  
Elvis Pirev ◽  
Florian Heβner ◽  
Ahmed Bozkurt ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Skin ◽  
Silver Ions ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Intracellular Zinc ◽  
Zinc Release

Singlet oxygen mediates the activation of JNK by UVA radiation in human skin fibroblasts

FEBS Letters ◽  
1997 ◽  
Vol 408 (3) ◽  
pp. 289-291 ◽  
Author(s):  
Lars-Oliver Klotz ◽  
Karlis Briviba ◽  
Helmut Sies
Keyword(s):  
Singlet Oxygen ◽  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Uva Radiation

The Effects of Baicalin Against UVA-Induced Photoaging in Skin Fibroblasts

2014 ◽  
Vol 42 (03) ◽  
pp. 709-727 ◽  
Author(s):  
Wei Min ◽  
Xin Liu ◽  
Qihong Qian ◽  
Bingjiang Lin ◽  
Di Wu ◽  
...  
Keyword(s):  
Protein Expression ◽  
Telomere Length ◽  
Human Skin ◽  
Human Fibroblasts ◽  
Underlying Mechanism ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Uva Irradiation ◽  
Anti Oxidant ◽  
Uva Radiation

Ultraviolet A (UVA) radiation contributes to skin photoaging. Baicalin, a plant-derived flavonoid, effectively absorbs UV rays and has been shown to have anti-oxidant and anti-inflammatory properties that may delay the photoaging process. In the current study, cultured human skin fibroblasts were incubated with 50 μg/ml baicalin 24 hours prior to 10 J/cm2UVA irradiation. In order to examine the efficacy of baicalin treatment in delaying UVA-induced photoaging, we investigated aging-related markers, cell cycle changes, anti-oxidant activity, telomere length, and DNA damage markers. UVA radiation caused an increased proportion of β-Gal positive cells and reduced telomere length in human skin fibroblasts. In addition, UVA radiation inhibited TGF-β1 secretion, induced G1 phase arrest, reduced SOD and GSH-Px levels, increased MDA levels, enhanced the expression of MMP-1, TIMP-1, p66, p53, and p16 mRNA, reduced c-myc mRNA expression, elevated p53 and p16 protein expression, and reduced c-myc protein expression. Baicalin treatment effectively protected human fibroblasts from these UVA radiation-induced aging responses, suggesting that the underlying mechanism involves the inhibition of oxidative damage and regulation of the expression of senescence-related genes, including those encoding for p53, p66Shcand p16.

scholarly journals Molecular response of human skin fibroblasts with a mutation m. 14441 T>C on the action of ionizing radiation in low and medium doses

2020 ◽  
pp. 91-93
Author(s):  
М.С. Абрамова ◽  
М.С. Конькова ◽  
В.Ю. Момот ◽  
А.А. Кальянов
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Dna ◽  
Ionizing Radiation ◽  
Human Skin ◽  
Healthy Donor ◽  
Cellular Response ◽  
Skin Fibroblasts ◽  
Molecular Response ◽  
Research Model ◽  
Human Skin Fibroblasts

В качестве модели для исследования были выбраны фибробласты с мутацией m.14441 T>C в гене ND6 и фибробласты здорового донора. Было показано, что данная мутация в гене ND6 митохондриальной ДНК (мтДНК) оказывает значительное влияние на ответ клеток во время окислительного стресса. Fibroblasts with the mutation of m.14441 T>C in the ND6 gene and fibroblasts of a healthy donor were chosen as a research model. It was shown that this mutation in the ND6 mitochondrial DNA gene has a significant effect on the cellular response during oxidative stress.

scholarly journals Protective Effects of Aucubin Isolated from Eucommia ulmoides against UVB-Induced Oxidative Stress in Human Skin Fibroblasts

2005 ◽  
Vol 28 (7) ◽  
pp. 1244-1248 ◽  
Author(s):  
Jin Nyoung Ho ◽  
Yoo Hyun Lee ◽  
Jong Seok Park ◽  
Woo Jin Jun ◽  
Hye Kyung Kim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Skin ◽  
Skin Fibroblasts ◽  
Eucommia Ulmoides ◽  
Protective Effects ◽  
Human Skin Fibroblasts
Sign in / Sign up

Export Citation Format

Share Document