A DIRECT TITRIMETRIC METHOD FOR THE DETERMINATION OF SOME ORGANIC BASES IN PHARMACEUTICAL PREPARATIONS

1963 ◽  
Vol 15 (1) ◽  
pp. 584-588 ◽  
Author(s):  
C. A. Johnson ◽  
R. E. King
Keyword(s):  
Pharmaceutical Preparations ◽  
Titrimetric Method ◽  
Organic Bases

A Review of Analytical Methods for the Determination of Hypericin in Foods, Herbal, Biological and Pharmaceutical Matrices

2020 ◽  
Vol 26 (36) ◽  
pp. 4648-4657
Author(s):  
Patricia Rocha de Araújo ◽  
Bruno Fonseca-Santos ◽  
Ana Carolina Kogawa ◽  
Hérida Regina Nunes Salgado ◽  
Marlus Chorilli
Keyword(s):  
Physicochemical Properties ◽  
Analytical Methods ◽  
Pharmaceutical Preparations ◽  
Antidepressant Activity ◽  
Biological Properties ◽  
Alkaline Solutions ◽  
Ultraviolet Region ◽  
Organic Bases ◽  
Layer Chromatography

Aims: A review of analytical methods for the determination of hypericin in foods, herbal, biological and pharmaceutical matrices. Background: Hypericin (HYP) is a naturally-occurring pigment obtained from some plants of the genus Hypericum. Although HYP has been known for many years, it has recently attracted attention due to its varied biological properties, such as anti-inflammatory and antidepressant activity and it is also an efficient photosensitizer. Objective: The objective of this review is to provide insights into the physicochemical properties of HYP, as well as to report the analytical methods existing in the literature and official compendia for different matrices. Methods: The survey data were collected by Google Scholar® and Scopus® using keys terms. Result: Analytical methods involving HYP are mainly concerned with the quality control of pharmaceutical preparations, foods, beverages, biological samples and drug delivery systems using different types of analysis methods. Some difficulties have also been identified due to the physicochemical properties of HYP. It presents great solubility in alkaline solutions, organic bases and common polar organic solvents. Conclusion: It can be analyzed by thin layer chromatography, spectrophotometry in the ultraviolet region, but the most commonly used method is by HPLC. HYP presents monographs in the American, British and European Pharmacopoeias, however, the methods of analysis are not yet harmonized.

scholarly journals TITRIMETRIC AND SPECTROPHOTOMETRIC ASSAY OF BUPROPION HYDROCHLORIDE IN PHARMACEUTICALS USING MERCURY(II) NITRATE

2018 ◽  
Vol 35 (3) ◽  
pp. 09
Author(s):  
M. A. Sameer Abdulaziz ◽  
K. Basavaiah ◽  
K. B. Vinay
Keyword(s):  
Good Accuracy ◽  
Pharmaceutical Preparations ◽  
Standard Addition ◽  
Chloride Content ◽  
Bromophenol Blue ◽  
Fixed Amount ◽  
Titrimetric Method ◽  
Accuracy And Precision ◽  
Reaction Stoichiometry

Two simple, rapid and accurate methods for the determination of bupropion hydrochloride (BUP) in pure and in pharmaceutical preparations are described. Both methods are based on the measurement of the chloride of its hydrochloride. In the titrimetric method, the chloride content of bupropion hydrochloride is determined by titrating with mercury(II)nitrate using diphenylcarbazone–bromophenol blue as indicator. Titrimetric method is applicable over a range 2–20 mg of BUP and the reaction stoichiometry is found to be 2:1 (BUP: Hg(NO3)2).The spectrophotometric method involves the addition of a measured excess of mercury(II) nitrate reagent in formate buffer to the drug, and after ensuring the reaction had gone to completion, the unreacted mercury(II) is treated with a fixed amount of diphenylcarbazone, and absorbance measured at 515 nm. The absorbance is found to decrease linearly with increasing concentration of BUP and the calibration curve is linear over 1.0–15.0 μg mL–1 BUP. The proposed methods were successfully applied to the determination of BUP in commerciallyavailable dosage forms with good accuracy and precision, and without  detectable interference by excipients. The accuracy was further ascertained by placebo blank and synthetic mixture analyses and also by recovery experiments via standard-addition procedure.

Simultaneous Spectrophotometric Determination of Salbutamol by Coupling with Diazotized 4-Aminobenzoic acid

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Hind Hadi ◽  
Gufran Salim
Keyword(s):  
Pharmaceutical Preparations ◽  
Coupling Reaction ◽  
Dosage Forms ◽  
Water Soluble ◽  
Trace Determination ◽  
Aminobenzoic Acid ◽  
Optimum Conditions ◽  
Colored Product ◽  
Versus Concentration

A simple, rapid and sensitive spectrophotmetric method for trace determination of salbutamol (SAL) in aqueous solution and in pharmaceutical preparations is described. The method is based on the diazotization coupling reaction of the intended compound with 4-amino benzoic acid (ABA) in alkaline medium to form an intense orange, water soluble dye that is stable and shows maximum absorption at 410 nm. A graph of absorbance versus concentration indicates that Beer’s law is obeyed over the concentration range of 0.5-30 ppm, with a molar absorbtivity 3.76×104 L.mol-1 .cm-1 depending on the concentration of SAL. The optimum conditions and stability of the colored product have been investigated and the method was applied successfully to the determination of SAL in dosage forms.

Colorimetric Determination of Amoxicillin in Pure and some Pharmaceutical Formulations Via Reaction with Potassium Permanganate as Oxidant Reagent

2019 ◽  
Vol 10 (02) ◽  
Author(s):  
Abbas Shebeeb Al-kadumi ◽  
Sahar Rihan Fadhel ◽  
Mohammed Abdullah Ahmed ◽  
Luma Amer Musa
Keyword(s):  
Potassium Permanganate ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Atomic Emission ◽  
Basic Medium ◽  
Photometric Method ◽  
Colorimetric Determination ◽  
Spectrophotometric Methods ◽  
Label Claim

We proposed two simple, rapid, and convenient spectrophotometric methods are described for the determination of Amoxicillin in bulk and its pharmaceutical preparations. They are based on the measurement of the flame atomic emission of potassium ion (in first method) and colorimetric determination of the green colored solution for manganite ion at 610 nm formed after reaction of Amoxicillin with potassium permanganate as oxidant agent (in the second method) in basic medium. The working conditions of the methods were investigated and optimized. Beer's law plot showed a good correlation in the concentration range of 5-45 μg/ml. The detection limits and relative standared deviations were (2.573, 2.814 μg/ml) (2.137, 2.498) for the flame emission photometric method and (1.844, 2.016 μg/ml) (1.645,1.932) for colorimetric methods for capsules and suspensions respectively. The methods were successfully applied to the determination of Amoxicillin in capsules and suspensions, and the obtained results were in good agreement with the label claim. No interference was observed from the commonly encountered additives and expectancies.

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