Differential effect of neuroleptic drugs on dopamine turnover in the extrapyramidal and limbic system

synopsisThe hypothesis that neuroleptic drugs exert their therapeutic effects by blocking dopaminergic transmission has been investigated by examining the effects of 3 neuroleptic drugs on dopamine turnover in 2 dopaminergically innervated regions of brain – the neostriatum and nucleus accumbens. The drugs chlorpromazine, thioridazine and fluphenazine, known to be therapeutically active in the treatment of schizophrenia, but to have differing incidences of extrapyramidal side effects, were administered to rats in dose ratios approximating to those effective in man. All 3 drugs induced a similar rise in the content of the dopamine metabolite homovanillic acid (HVA) in the nucleus accumbens, whilst the changes in HVA observed in the neostriatum were in the rank order in which these drugs produce extrapyramidal side effects. While the concentrations of dopamine metabolites in the frontal cortex were too low to assess the possibility that neuroleptic drugs have actions at this level, our results are consistent with the hypothesis that these drugs exert their therapeutic effects by dopamine receptor blockade in the nucleus accumbens.

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Dopamine turnover in the corpus striatum and the limbic system after treatment with neuroleptic and anti-acetylcholine drugs

Journal of Pharmacy and Pharmacology ◽

10.1111/j.2042-7158.1972.tb08912.x ◽

1972 ◽

Vol 24 (11) ◽

pp. 905-906 ◽

Cited By ~ 196

Author(s):

Nils-Erik Andén

Keyword(s):

Limbic System ◽

Corpus Striatum ◽

Dopamine Turnover ◽

Anti Acetylcholine

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359 Cardiac lesions induced by neuroleptic drugs in the rabbit

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(06)80221-3 ◽

2006 ◽

Vol 5 (1) ◽

pp. 78-78

Author(s):

D BELHANI ◽

D FRASSATI ◽

R MEGARD ◽

Q TIMOURCHAH ◽

B BUIXUAN ◽

...

Keyword(s):

Neuroleptic Drugs ◽

Cardiac Lesions

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The Mere Exposure Effect and Recognition Depend on the Way You Look! *S. W. and J. D. contributed equally to this study.

Experimental Psychology (formerly Zeitschrift für Experimentelle Psychologie) ◽

10.1027/1618-3169/a000023 ◽

2010 ◽

Vol 57 (3) ◽

pp. 185-192 ◽

Cited By ~ 6

Author(s):

Sylvie Willems ◽

Jonathan Dedonder ◽

Martial Van der Linden

Keyword(s):

Differential Effect ◽

Recognition Task ◽

Mere Exposure ◽

Perceptual Processing ◽

Processing Strategy ◽

Mere Exposure Effect ◽

Exposure Effect ◽

Processing Strategies ◽

Explicit Recognition ◽

Analytic Strategy

In line with Whittlesea and Price (2001) , we investigated whether the memory effect measured with an implicit memory paradigm (mere exposure effect) and an explicit recognition task depended on perceptual processing strategies, regardless of whether the task required intentional retrieval. We found that manipulation intended to prompt functional implicit-explicit dissociation no longer had a differential effect when we induced similar perceptual strategies in both tasks. Indeed, the results showed that prompting a nonanalytic strategy ensured performance above chance on both tasks. Conversely, inducing an analytic strategy drastically decreased both explicit and implicit performance. Furthermore, we noted that the nonanalytic strategy involved less extensive gaze scanning than the analytic strategy and that memory effects under this processing strategy were largely independent of gaze movement.

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